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NKX2-1 encodes a protein initially identified as a thyroid-specific transcription factor. Additionally we are shipping NK2 Homeobox 1 Kits (19) and NK2 Homeobox 1 Proteins (7) and many more products for this protein.
Showing 10 out of 199 products:
Human Monoclonal NKX2-1 Primary Antibody for FACS, IHC (p) - ABIN1688762
Vyberg, Nielsen: Proficiency testing in immunohistochemistry-experiences from Nordic Immunohistochemical Quality Control (NordiQC). in Virchows Archiv : an international journal of pathology 2016
Show all 5 references for ABIN1688762
Human Polyclonal NKX2-1 Primary Antibody for EIA, IF - ABIN1450126
Guazzi, Price, De Felice, Damante, Mattei, Di Lauro: Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. in The EMBO journal 1990
Show all 4 references for ABIN1450126
Human Polyclonal NKX2-1 Primary Antibody for IHC, ELISA - ABIN1532418
Freeman, Yamamoto: Disassembly of transcriptional regulatory complexes by molecular chaperones. in Science (New York, N.Y.) 2002
These findings describe recurrent NKX2-1 mutations in invasive mucinous adenocarcinomas of the lung and support NKX2-1 as a lineage-specific tumor suppressor gene in lung carcinogenesis.
Report TTF1 expression is common in combined Merkel cell carcinoma.
Preoperative serum miR (show MLXIP Antibodies)-365 and TTF-1 mRNA levels may be effective indicators of tumor aggressiveness in human NSCLC. miR (show MLXIP Antibodies)-365 and its target gene TTF-1 appear to be synergistic risk factors for the reduction in overall survival of patients with NSCLC.
In adenocarcinomas from extrahepatic biliary tract, there was no correlation between TTF-1 expression and the clinicopathological characteristics.
Suggest TTF-1 is a reliable marker in non-small cell lung carcinoma and can be used in differential diagnosis.
EGFR (show EGFR Antibodies) knockdown led to upregulation of NKX2-1, suggesting a negative feedback loop. combined knockdown of NKX2-1 and EGFR (show EGFR Antibodies) in NCI-H1819 lung cancer cells reduced cell proliferation more than knockdown of either alone.
TTF-1 had no prognostic value concerning OS, but may serve as a predictor for response to first line chemotherapy in small cell lung cancer.
Authors suggest that NKX2-1 as a tumour suppressor or a tumour promoter in lung adenocarcinoma progression is dependent on p53 (show TP53 Antibodies) status.
TTF-1 is considered to be an excellent marker of pituicytes, specialized glia of the neurohypophysis.
Aberrant expression of mir (show MLXIP Antibodies)-365/TTF-1 may be involved in the tumor development in patients with non-small cell lung carcinoma.
Identify regulatory link between Nkx2-1, miR (show MLXIP Antibodies)-200c, and the transcription factors Nfib (show NFIB Antibodies) and Myb (show MYB Antibodies), adding new players to the regulatory mechanisms driven by Nkx2-1 in lung epithelial cells that may have implications in lung development and tumorigenesis.
A population of neural stem cells in the ventral region of the adult ventricular-subventricular zone expresses the transcription factor Nkx2.1 and is derived from Nkx2.1-expressing (Nkx2.1+) embryonic precursors.
We conclude that a dedicated subset of VMHVL neurons marked by ERalpha (show ESR1 Antibodies), NKX2-1, and Tac1 (show TAC1 Antibodies) regulates estrogen-dependent fluctuations in physical activity and constitutes one of several neuroendocrine modules that drive sex-specific responses.
Prototypic GPe neurons derive from the medial ganglionic eminence of the embryonic subpallium and express the transcription factor Nkx2-1. These neurons fire at high rates during alert rest, and encode movements through heterogeneous firing rate changes.
Molecular characterization of disseminated tumor cells indicates that downregulation of the transcription factor Nkx2-1 precedes lung adenocarcinoma dissemination.
The Nkx2-1-mediated pathway in the DMH (show DST Antibodies) and LH stimulates skeletal muscle function via the sympathetic nervous system and maintains youthful physiology, contributing to the delay in aging and life span extension.
MicroRNA-33a mediates the regulation of high mobility group AT-hook 2 gene (HMGA2) by thyroid transcription factor 1 (TTF-1/NKX2-1).
A review of recent findings with special attention given to the role of NKX2-1 in lung development and carcinogenesis.
we report the generation of transgenic mouse lines that overexpress wild-type p23 (show CDK5R1 Antibodies) or uncleavable p23 (show CDK5R1 Antibodies)
Apc (show APC Antibodies) and TGF-beta (show TGFB1 Antibodies) signaling have roles in regulating the key transcriptional factor, Nkx2.1, for lung epithelial progenitor cell fate determination
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.
thyroid transcription factor 1
, NK2 homeobox 1
, NK-2 homolog A
, homeobox protein NK-2 homolog A
, homeobox protein Nkx-2.1
, thyroid nuclear factor 1
, thyroid-specific enhancer-binding protein
, thyroid transcription factor 1 TTF-1 NK-2
, thyroid transcription factor-1
, homeodomain protein NKx2.1
, cytosolic prostaglandin E2 synthase
, hsp90 co-chaperone
, p23 cochaperone
, progesterone receptor complex p23
, prostaglandin E synthase 3
, sid 3177
, telomerase binding protein, p23
, telomerase-binding protein p23