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anti-NK2 Homeobox 5 (NKX2-5) Antibodies

NKX2-5 encodes a homeobox-containing transcription factor. Additionally we are shipping NK2 Homeobox 5 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NKX2-5 1482 P52952
NKX2-5 18091 P42582
NKX2-5 114109 O35767
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Top anti-NK2 Homeobox 5 Antibodies at antibodies-online.com

Showing 10 out of 128 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Nkx2-5 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Goat Un-conjugated EIA, WB Anti-CSX1 (0.3µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated FACS, ICC, IF, WB Immunocytochemistry/Immunofluorescence: NKX2.5 Antibody [NBP1-31558] - Paraformaldehyde-fixed HeLa, using antibody at 1:200 dilution. Western Blot: NKX2.5 Antibody [NBP1-31558] - Rat heart lysate/extract. 100 μL Log in to see 5 to 7 Days
$447.56
Details
Human Mouse Un-conjugated ELISA, WB Figure 1: Western blot analysis using NKX2.5 mouse mAb against full-length NKX2.5 (aa1-324) -hIgGFc transfected HEK293 cell lysate (1) . 100 μL Log in to see 3 to 4 Days
$393.80
Details
Human Goat Un-conjugated ELISA, WB Western Blot: NKX2.5 Antibody [NBP1-51953] - Nkx2.5 Antibody [NBP1-51953] - Western blot analysis of Nkx2.5 in Human Heart lysate (35ug protein in RIPA buffer) using NBP1-51953 at 0.3ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 5 to 7 Days
$408.19
Details
Mouse Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat heart labeled with Anti-Nkx2.5/Cardiac-specific homeobox 1 Polyclonal Antibody, Unconjugated (ABIN872721) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$307.45
Details
Human Rabbit Un-conjugated WB Anti- NKX2 Picoband antibody, Western blotting All lanes: Anti NKX2  at 0.5ug/ml Lane 1: Mouse Spleen Tissue Lysate at 50ug Lane 2: Mouse Cardiac Muscle Tissue Lysate at 50ug Lane 3: HELA Whole Cell Lysate at 40ug Predicted bind size: 35KD Observed bind size: 35KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$481.25
Details
Human Mouse Un-conjugated ELISA, WB NKX2-5 monoclonal antibody (M01), clone 1E4-G5. Western Blot analysis of NKX2-5 expression in human thyroid(diffuse hyperplasia). NKX2-5 monoclonal antibody (M01), clone 1E4-G5 Western Blot analysis of NKX2-5 expression in HeLa . 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB NKX2-5 Antibody (Center)  western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the NKX2-5 antibody detected the NKX2-5 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details

NKX2-5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-NK2 Homeobox 5 Antibodies

  1. Human Monoclonal NKX2-5 Primary Antibody for ELISA, WB - ABIN560515 : Yadava, Frenzel-McCardell, Yu, Srinivasan, Tucker, Puymirat, Thornton, Prall, Harvey, Mahadevan: RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression. in Nature genetics 2007 (PubMed)
    Show all 2 references for ABIN560515

  2. Human Monoclonal NKX2-5 Primary Antibody for ELISA, WB - ABIN969487 : Ikeda, Hiroi, Hosoda, Utsunomiya, Matsuo, Ito, Inoue, Sumiyoshi, Takano, Nagai, Komuro: Novel point mutation in the cardiac transcription factor CSX/NKX2.5 associated with congenital heart disease. in Circulation journal : official journal of the Japanese Circulation Society 2002 (PubMed)
    Show all 2 references for ABIN969487

  3. Human Polyclonal NKX2-5 Primary Antibody for FACS, ICC - ABIN441557 : Ramachandra, Shim: Evaluation of sarcomeric organization in human pluripotent stem cell-derived cardiomyocytes. in Methods in molecular biology (Clifton, N.J.) 2015 (PubMed)
    Show all 2 references for ABIN441557

  4. Cow (Bovine) Polyclonal NKX2-5 Primary Antibody for WB - ABIN2779388 : Nagel, Meyer, Quentmeier, Kaufmann, Drexler, MacLeod: MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines. in Leukemia 2008 (PubMed)

  5. Mouse (Murine) Polyclonal NKX2-5 Primary Antibody for IF (p), IHC (p) - ABIN872721 : Ruan, Zhu, Yin, Chen: Inhibitor of p53-p21 pathway induces the differentiation of human umbilical cord derived mesenchymal stem cells into cardiomyogenic cells. in Cytotechnology 2016 (PubMed)

  6. Cow (Bovine) Polyclonal NKX2-5 Primary Antibody for EIA, WB - ABIN615913 : Briggs, Takeda, Cuadra, Wakimoto, Marks, Walker, Seki, Oh, Lu, Sumners, Raizada, Horikoshi, Weinberg, Yasui, Ikeda, Chien, Kasahara: Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects. in Circulation research 2008 (PubMed)

More Antibodies against NK2 Homeobox 5 Interaction Partners

Human NK2 Homeobox 5 (NKX2-5) interaction partners

  1. NKX2-5 mutations mainly occur in familial congenital heart defects, the signature phenotype is atrial septal defects with conduction disturbances and mutation carriers are at increased risk of sudden cardiac death.

  2. 187QNRRYKCKRQR197 was required for exclusive nuclear localization of NKX2.5.

  3. NKX2.5 and GATA4 (show GATA4 Antibodies) gene mutations might participate in the development of congenital heart disease and can promote bone marrow derived stroma cell differentiate into cardiomyocytes.

  4. Data indicate that cells cultured on cardiac muscle laminin (LN)-based substrata in combination with stimulation of the canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway showed increased gene expression of ISL1 (show ISL1 Antibodies), OCT4 (show POU5F1 Antibodies), KDR (show KDR Antibodies) and NKX2.5.

  5. There was no evidence of a role for NKX2-5 and GATA4 (show GATA4 Antibodies) CNV in fetal CHD (show CHDH Antibodies); therefore, these CNV may not be common in fetal CHD (show CHDH Antibodies) in China

  6. Overexpression of Nkx2.5 significantly promotes the differentiation of human umbilical cord drived mesenchymal stem cells into cardiomyocytes.

  7. Egyptian T-cell acute lymphoblastic leukemia cases seemed to have a different genetic pattern compared to other populations, with a lower incidence of TLX3/HOX11L2 (show TLX3 Antibodies) and SIL (show PMEL Antibodies)/TAL (show TALDO1 Antibodies) but a higher incidence of NKX2-5 expression than recorded in Western countries

  8. This study reveals a novel pathway that directly links ErbB4 (show ERBB4 Antibodies) and p38gamma (show MAPK12 Antibodies) to the transcriptional machinery of NKx2.5-GATA4 (show GATA4 Antibodies) complex which is critical for cardiomyocyte formation during mammalian heart development.

  9. the single nucleotide polymorphism rs2277923 of NKX2-5 gene contributes to the risk of sporadic congenital heart disease in Chinese Bai people.

  10. the frequency of NKX2.5 gene mutations among the patient with Atrial septal defect: in 80% of the affected individuals two polymorphic sites are located at position 487 and 495.

Mouse (Murine) NK2 Homeobox 5 (NKX2-5) interaction partners

  1. Using a combination of mouse genetics, biochemistry, molecular and cell biology, we demonstrate that Nkx2-5 regulates the gene encoding Kcnh2 (show KCNH2 Antibodies) channel and others, shedding light on potential mechanisms generating electrical abnormalities observed in patients bearing NKX2-5 dysfunction and opening opportunities to the study of novel therapeutic targets for anti-arrhythmogenic therapies

  2. In the absence of NKX2-5 (or Smad-6 (show SMAD6 Antibodies)), a severe form of rheumatic heart disease is observed.

  3. Study reports extensive and complex interdependent genomic occupancy of TBX5 (show TBX5 Antibodies), NKX2-5, and the zinc finger TF GATA4 (show GATA4 Antibodies) coordinately controlling cardiac gene expression, differentiation, and morphogenesis.

  4. Sequential binding of MEIS1 (show MEIS1 Antibodies) and NKX2-5 on the Popdc2 (show POPDC2 Antibodies) gene demonstrate a mechanism for spatiotemporal regulation of enhancers during cardiogenesis.

  5. The model proposed will help to elucidate the molecular basis for disease causing mutations in GATA4 and NKX2-5 and may be relevant to other members of the GATA and NK classes of transcription factors.

  6. MSCs thus form a 'mechanical memory' of rigidity by progressively suppressing NKX2.5, thereby elevating SMA (show SMN1 Antibodies) in a scar-like state.

  7. the Shox2 (show SHOX2 Antibodies)-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node

  8. Findings implicate a novel, temporal-specific role of Mzf1 (show ZSCAN1 Antibodies) in embryonic heart development and show that Mzf1 (show ZSCAN1 Antibodies) bounds directly to the Nkx2.5 during murine embryonic stem cell differentiation.

  9. A heterozygous Nkx2-5 missense mutation in the homeodomain demonstrates a high penetrance of diverse cardiac anomalies, similar to or more profound than those observed in human patients.

  10. our findings reveal a novel mechanism for regulation of SCFFbox25-dependent Nkx2-5 and Tbx5 (show TBX5 Antibodies) ubiquitination in cardiac development and provide a new insight into the regulatory mechanism of Nkx2-5 and Tbx5 (show TBX5 Antibodies) transcriptional activity.

NK2 Homeobox 5 (NKX2-5) Antigen Profile

Protein Summary

This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with anti-NK2 Homeobox 5 (NKX2-5) Antibodies

  • NK2 transcription factor related, locus 5 (Drosophila) (NKX2-5) antibody
  • Nkx2.5 protein (nkx2.5) antibody
  • NK2 transcription factor related, locus 5 (nkx2-5) antibody
  • NK2 homeobox 5 (NKX2-5) antibody
  • NK2 homeobox 5 (Nkx2-5) antibody
  • Nkx-2.5 homeobox protein (NKX-2.5) antibody
  • CHNG5 antibody
  • CNKX-2.5 antibody
  • Csx antibody
  • CSX1 antibody
  • HLHS2 antibody
  • NKX-2.5 antibody
  • Nkx2-5 antibody
  • NKX2.5 antibody
  • NKX2E antibody
  • NKX4-1 antibody
  • tinman antibody
  • VSD3 antibody
  • XNkx-2.5 antibody
  • XNkx2-5 antibody

Protein level used designations for anti-NK2 Homeobox 5 (NKX2-5) Antibodies

NK2 transcription factor related, locus 5 (Drosophila) , NK2 transcription factor locus 5-like , Nkx2.5 protein , NK2 transcription factor related, locus 5 , cardiac-specific homeobox 1 , homeobox protein CSX , homeobox protein NK-2 homolog E , homeobox protein Nkx-2.5 , tinman paralog , transcription factor NKX2.5 , Drosophila NK2 transcription factor related, locus 5 , cardiac-specific homeobox , rNKx-2.5

GENE ID SPECIES
462273 Pan troglodytes
703795 Macaca mulatta
100026700 Monodelphis domestica
100125478 Oryzias latipes
100144646 Xenopus (Silurana) tropicalis
1482 Homo sapiens
489113 Canis lupus familiaris
538870 Bos taurus
18091 Mus musculus
114109 Rattus norvegicus
396073 Gallus gallus
100009490 Oryctolagus cuniculus
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