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NKX2-5 encodes a homeobox-containing transcription factor. Additionally we are shipping NK2 Homeobox 5 Proteins (5) and many more products for this protein.
Showing 10 out of 122 products:
Human Monoclonal NKX2-5 Primary Antibody for ELISA, WB - ABIN560515
Yadava, Frenzel-McCardell, Yu, Srinivasan, Tucker, Puymirat, Thornton, Prall, Harvey, Mahadevan: RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression. in Nature genetics 2007
Show all 2 references for ABIN560515
Human Monoclonal NKX2-5 Primary Antibody for ELISA, WB - ABIN969487
Ikeda, Hiroi, Hosoda, Utsunomiya, Matsuo, Ito, Inoue, Sumiyoshi, Takano, Nagai, Komuro: Novel point mutation in the cardiac transcription factor CSX/NKX2.5 associated with congenital heart disease. in Circulation journal : official journal of the Japanese Circulation Society 2002
Show all 2 references for ABIN969487
Human Polyclonal NKX2-5 Primary Antibody for FACS, ICC - ABIN441557
Ramachandra, Shim: Evaluation of sarcomeric organization in human pluripotent stem cell-derived cardiomyocytes. in Methods in molecular biology (Clifton, N.J.) 2015
Show all 2 references for ABIN441557
Cow (Bovine) Polyclonal NKX2-5 Primary Antibody for WB - ABIN2779388
Nagel, Meyer, Quentmeier, Kaufmann, Drexler, MacLeod: MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines. in Leukemia 2008
Cow (Bovine) Polyclonal NKX2-5 Primary Antibody for EIA, WB - ABIN615913
Briggs, Takeda, Cuadra, Wakimoto, Marks, Walker, Seki, Oh, Lu, Sumners, Raizada, Horikoshi, Weinberg, Yasui, Ikeda, Chien, Kasahara: Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects. in Circulation research 2008
the frequency of NKX2.5 gene mutations among the patient with Atrial septal defect: in 80% of the affected individuals two polymorphic sites are located at position 487 and 495.
The crystal structure and binding domains were identified in cardiac NKX2.5.
We describe in this study the mutational and expression analysis of the NKX2.5 gene in nonsyndromic CHD (show CHDH Antibodies) patients
NKX2.5 mutations were not found. The c.63A>G polymorphism might be associated with thyroid hypoplasia.
Our findings demonstrate that somatic NKX2-5 mutations do not represent an important aetiologic pathway in Chinese children with congenital heart disease.
Combined expression of NKX2-5, HAND1 (show HAND1 Antibodies), and NOTCH1 (show NOTCH1 Antibodies) coordinately contribute to cardiac malformations in Hhypoplastic left heart syndrome.
The novel DSV (1500G>C) of NKX2-5 gene (show GPD1 Antibodies) may contribute to a small number of VSD, and rs2277923 SNP may contribute to the risk of sporadic ASD (show ARSD Antibodies) in Chinese Yunnan population.
Nkx2-5 (and Isl1 (show ISL1 Antibodies)) regulate the specification of cardiac progenitor cells and acquisition of cardiomyocyte subtype identity.
Germline mutations in the NKX2-5, GATA4 (show GATA4 Antibodies), and CRELD1 (show CRELD1 Antibodies) genes do not appear to be associated with CHD (show CHDH Antibodies) in Mexican DS patients.
NKX2-5 is thus responsible for dominant familial ASD (show ARSD Antibodies) even in consanguineous populations, and a wide genetic and phenotypic diversity is characteristic of NKX2-5 mutations in the Lebanese population.
In the absence of NKX2-5 (or Smad-6 (show SMAD6 Antibodies)), a severe form of rheumatic heart disease is observed.
Study reports extensive and complex interdependent genomic occupancy of TBX5 (show TBX5 Antibodies), NKX2-5, and the zinc finger TF GATA4 (show GATA4 Antibodies) coordinately controlling cardiac gene expression, differentiation, and morphogenesis.
Sequential binding of MEIS1 (show MEIS1 Antibodies) and NKX2-5 on the Popdc2 (show POPDC2 Antibodies) gene demonstrate a mechanism for spatiotemporal regulation of enhancers during cardiogenesis.
The model proposed will help to elucidate the molecular basis for disease causing mutations in GATA4 and NKX2-5 and may be relevant to other members of the GATA and NK classes of transcription factors.
MSCs thus form a 'mechanical memory' of rigidity by progressively suppressing NKX2.5, thereby elevating SMA (show SMN1 Antibodies) in a scar-like state.
the Shox2 (show SHOX2 Antibodies)-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node
Findings implicate a novel, temporal-specific role of Mzf1 (show ZSCAN1 Antibodies) in embryonic heart development and show that Mzf1 (show ZSCAN1 Antibodies) bounds directly to the Nkx2.5 during murine embryonic stem cell differentiation.
A heterozygous Nkx2-5 missense mutation in the homeodomain demonstrates a high penetrance of diverse cardiac anomalies, similar to or more profound than those observed in human patients.
our findings reveal a novel mechanism for regulation of SCFFbox25-dependent Nkx2-5 and Tbx5 (show TBX5 Antibodies) ubiquitination in cardiac development and provide a new insight into the regulatory mechanism of Nkx2-5 and Tbx5 (show TBX5 Antibodies) transcriptional activity.
Results show that NKX2-5 mRNA levels correlate with muscle histopathology in mice and humans and find that NKX2-5 levels modify disease phenotypes in mice with RNA toxicity.
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
NK2 transcription factor related, locus 5 (Drosophila)
, NK2 transcription factor locus 5-like
, Nkx2.5 protein
, NK2 transcription factor related, locus 5
, cardiac-specific homeobox 1
, homeobox protein CSX
, homeobox protein NK-2 homolog E
, homeobox protein Nkx-2.5
, tinman paralog
, transcription factor NKX2.5
, Drosophila NK2 transcription factor related, locus 5
, cardiac-specific homeobox