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NKX3-2 encodes a member of the NK family of homeobox-containing proteins. Additionally we are shipping NK3 Homeobox 2 Proteins (5) and NK3 Homeobox 2 Kits (1) and many more products for this protein.
Showing 10 out of 48 products:
Chicken Polyclonal NKX3-2 Primary Antibody for WB - ABIN2787533
Rodrigo, Bovolenta, Mankoo, Imai: Meox homeodomain proteins are required for Bapx1 expression in the sclerotome and activate its transcription by direct binding to its promoter. in Molecular and cellular biology 2004
Show all 2 references for ABIN2787533
Chicken Polyclonal NKX3-2 Primary Antibody for WB - ABIN2779821
Provot, Kempf, Murtaugh, Chung, Kim, Chyung, Kronenberg, Lassar: Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturation. in Development (Cambridge, England) 2006
Human Polyclonal NKX3-2 Primary Antibody for ELISA, WB - ABIN560031
Verzi, Stanfel, Moses, Kim, Zhang, Schwartz, Shivdasani, Zimmer: Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. in Gastroenterology 2009
Human Polyclonal NKX3-2 Primary Antibody for EIA, WB - ABIN783403
Tribioli, Frasch, Lufkin: Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton. in Mechanisms of development 1997
Bapx1-endothelin 1 (show EDN1 Antibodies) effector, patterns jaw joint
PI3K (show PIK3CA Antibodies)-mediated suppression of Nkx3.2 in chondrocytes plays a role in the control of cartilage hypertrophy during skeletal development in vertebrates.
Our findings indicate that BAPX-1/NKX-3.2 is a molecular switch that is involved in controlling the hypertrophic phenotype of the postdevelopmental (OA) articular chondrocyte.
Ihh (show IHH Antibodies)-induced Nkx3.2 degradation requires Wnt5a (show WNT5A Antibodies), which is capable of triggering Nkx3.2 degradation
Data show that IkappaB kinase (show CHUK Antibodies) beta (IKKbeta (show IKBKB Antibodies)) can be activated in the nucleus by Nkx3.2 in the absence of exogenous IKK (show CHUK Antibodies)-activating signals, allowing constitutive nuclear degradation of IkappaB-alpha (show NFKBIA Antibodies).
NKX3-2 plays an important role in endochondral ossification of both the axial and appendicular skeleton in humans
Data show that Meox1 (show MEOX1 Antibodies) activates the Bapx1 promoter in a dose-dependent manner and that this activity is enhanced in the presence of Pax1 (show PAX1 Antibodies) and/or Pax9 (show PAX9 Antibodies).
Nkx3.2 promotes primary chondrogenesis by two mechanisms: Direct and Sox9 (show SOX9 Antibodies)-independent upregulation of Col2a1 (show COL2A1 Antibodies) transcription and upregulation of Sox9 (show SOX9 Antibodies) mRNA expression under positive feedback system.
the balance of Pax3 (show PAX3 Antibodies), Nkx3.2 and Sox9 (show SOX9 Antibodies) may act as a molecular switch during the chondrogenic differentiation of muscle progenitor cells, which may be important for fracture healing.
These results demonstrated that Nkx3.2-dependent suppression of Runx2 (show RUNX2 Antibodies) was a crucial factor in hypoxia-dependent maintenance of chondrocyte identity.
Targeted disruption of the Nkx3.2 (Bapx1) gene in mice results in limited defects of chondrocranial bones and the axial skeleton, particularly pronounced in cervical vertebrae.
Pax1 (show PAX1 Antibodies) and Pax9 (show PAX9 Antibodies) can transactivate regulatory sequences in the Bapx1 promoter to induce chondrogenic differentiation in the sclerotome.
Nkx3.2 has a critical role in the induction of somitic chondrogenesis
in the Bapx1 mutant embryo, Fgf10 (show FGF10 Antibodies) expression is downregulated and the dorsal pancreas remains at the midline
Nkx3.2 represses expression of the chondrocyte maturation factor Runx2 (show RUNX2 Antibodies), and Runx2 (show RUNX2 Antibodies) mis (show AMH Antibodies)-expression can rescue the Nkx3.2-induced blockade of chondrocyte maturation.
This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development.
NK3 homeobox 2
, bagpipe homeobox homolog 1
, homeobox protein Nkx-3.2
, bagpipe homeobox protein homolog 1
, NK class homeoprotein Nkx-3.2
, homeobox protein NK-3 homolog B
, bagpipe homeobox gene 1 homolog
, homeodomain protein Nkx-3.2