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NKX3-2 encodes a member of the NK family of homeobox-containing proteins. Additionally we are shipping NK3 Homeobox 2 Antibodies (48) and NK3 Homeobox 2 Proteins (5) and many more products for this protein.
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Bapx1-endothelin 1 (show EDN1 ELISA Kits) effector, patterns jaw joint
Our findings indicate that BAPX-1/NKX-3.2 is a molecular switch that is involved in controlling the hypertrophic phenotype of the postdevelopmental (OA) articular chondrocyte.
Ihh (show IHH ELISA Kits)-induced Nkx3.2 degradation requires Wnt5a (show WNT5A ELISA Kits), which is capable of triggering Nkx3.2 degradation
Data show that IkappaB kinase (show CHUK ELISA Kits) beta (IKKbeta (show IKBKB ELISA Kits)) can be activated in the nucleus by Nkx3.2 in the absence of exogenous IKK (show CHUK ELISA Kits)-activating signals, allowing constitutive nuclear degradation of IkappaB-alpha (show NFKBIA ELISA Kits).
NKX3-2 plays an important role in endochondral ossification of both the axial and appendicular skeleton in humans
Data show that Meox1 (show MEOX1 ELISA Kits) activates the Bapx1 promoter in a dose-dependent manner and that this activity is enhanced in the presence of Pax1 (show PAX1 ELISA Kits) and/or Pax9 (show PAX9 ELISA Kits).
Nkx3.2 promotes primary chondrogenesis by two mechanisms: Direct and Sox9 (show SOX9 ELISA Kits)-independent upregulation of Col2a1 (show COL2A1 ELISA Kits) transcription and upregulation of Sox9 (show SOX9 ELISA Kits) mRNA expression under positive feedback system.
the balance of Pax3 (show PAX3 ELISA Kits), Nkx3.2 and Sox9 (show SOX9 ELISA Kits) may act as a molecular switch during the chondrogenic differentiation of muscle progenitor cells, which may be important for fracture healing.
These results demonstrated that Nkx3.2-dependent suppression of Runx2 (show RUNX2 ELISA Kits) was a crucial factor in hypoxia-dependent maintenance of chondrocyte identity.
Targeted disruption of the Nkx3.2 (Bapx1) gene in mice results in limited defects of chondrocranial bones and the axial skeleton, particularly pronounced in cervical vertebrae.
Pax1 (show PAX1 ELISA Kits) and Pax9 (show PAX9 ELISA Kits) can transactivate regulatory sequences in the Bapx1 promoter to induce chondrogenic differentiation in the sclerotome.
Nkx3.2 has a critical role in the induction of somitic chondrogenesis
in the Bapx1 mutant embryo, Fgf10 (show FGF10 ELISA Kits) expression is downregulated and the dorsal pancreas remains at the midline
Nkx3.2 represses expression of the chondrocyte maturation factor Runx2 (show RUNX2 ELISA Kits), and Runx2 (show RUNX2 ELISA Kits) mis (show AMH ELISA Kits)-expression can rescue the Nkx3.2-induced blockade of chondrocyte maturation.
This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development.
NK3 homeobox 2
, bagpipe homeobox homolog 1
, homeobox protein Nkx-3.2
, bagpipe homeobox protein homolog 1
, NK class homeoprotein Nkx-3.2
, homeobox protein NK-3 homolog B
, bagpipe homeobox gene 1 homolog
, homeodomain protein Nkx-3.2