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In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. Additionally we are shipping NK6 Homeobox 1 Kits (3) and NK6 Homeobox 1 Proteins (3) and many more products for this protein.
Showing 10 out of 84 products:
Human Monoclonal NKX6-1 Primary Antibody for BI, IF - ABIN2689864
Donelan, Koya, Li, Yang: Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells. in The Journal of biological chemistry 2010
Show all 6 references for ABIN2689864
Human Polyclonal NKX6-1 Primary Antibody for EIA, WB - ABIN953718
Zhu, Xia, Yang, Ma, Chen, Hu, Gu, Liang, Lin, Wong: Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia. in Digestive diseases and sciences 2009
Show all 4 references for ABIN953718
Human Polyclonal NKX6-1 Primary Antibody for ICC, IF - ABIN4340070
Bader, Migliorini, Gegg, Moruzzi, Gerdes, Roscioni, Bakhti, Brandl, Irmler, Beckers, Aichler, Feuchtinger, Leitzinger, Zischka, Wang-Sattler, Jastroch, Tschöp, Machicao, Staiger, Häring, Chmelova et al.: Identification of proliferative and mature β-cells in the islets of Langerhans. ... in Nature 2016
Show all 3 references for ABIN4340070
Cow (Bovine) Polyclonal NKX6-1 Primary Antibody for WB - ABIN2777547
Schisler, Fueger, Babu, Hohmeier, Tessem, Lu, Becker, Naziruddin, Levy, Mirmira, Newgard: Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. in Molecular and cellular biology 2008
a significant relationship was observed between NKX6.1 and EMT (show ITK Antibodies) marker expression levels, and NKX6.1 knockdown inhibited cell invasion, and overexpression of NKX6.1 promotes cell proliferation in vitro.
study evaluated the potential use of NKX6-1 as a diagnostic marker for well-differentiated neuroendocrine tumors
NKX6-1 reveals wide variations in methylation levels in normal control samples of cervical adenocarcinomas.
Mice transplanted with NKX6.1-low cells remained hyperglycemic throughout the 5-month post-transplant period whereas diabetes was reversed in NKX6.1-high recipients within 3 months.
MAFA (show KLRG1 Antibodies), MAFB (show MAFB Antibodies), NKX6.1, and PDX1 (show PDX1 Antibodies) activity provides a gauge of islet beta cell function, with loss of MAFA (show KLRG1 Antibodies) (and/or MAFB (show MAFB Antibodies)) representing an early indicator of beta cell inactivity
Smooth muscle cells expressing nestin (show NES Antibodies) and Nkx6.1 are the main cell population derived from culturing human spinal cord cells in adherent conditions with serum.
Data suggest that NKX6.1 activates immature pancreatic markers but not pancreatic hormone (show PPY Antibodies) gene expression in human liver cells, and suggest a potential role for NKX6.1 in promoting PDX-1 (show PDX1 Antibodies) reprogrammed maturation along a beta (show SUCLA2 Antibodies)-cell-like lineage.
identified an NKX6.1 recognition sequence in the distal region of the HNF1alpha (show HNF1A Antibodies) promoter and demonstrated specific binding of NKX6.1 in beta cells
Nkx6.1 is a bifunctional transcription factor that serves to maintain the specific expression of its own gene during beta-cell differentiation while simultaneously effecting broader gene repression events
overexpression of Nkx6.1 in islets caused an increase in the level of [(3)H]thymidine incorporation that was twice the control level, along with complete retention of glucose-stimulated insulin (show INS Antibodies) secretion
nkx6.1 regulates the alpha- and beta-cell formation in zebrafish by acting on the stem cells in the Islets of Langerhans.
In zebrafish, Nkx6.1 is expressed in early-born primary and later-born secondary motoneurons
Study shows that zebrafish primary motoneurons express two related transcription factors Nkx6.1 and Nkx6.2; in their absence, the CaP motoneuron subtype develops normally, whereas the MiP (show MIP Antibodies) motoneuron subtype develops a interneuron-like morphology.
The results suggest that Nkx6.1 is involved in mid-hindbrain formation in Xenopus embryos, likely by modulating wnt1 (show WNT1 Antibodies) expression.
Nkx6.1 and Nkx6.2 share overlapping expression domains in the ventral neural tube at neurula stages and later in the ventral part of developing hindbrain and spinal cord. Nkx6.3 (show NKX6-3 Antibodies) is detected in the non-neural ectoderm.
Nkx6.1 plays a vital role in astrocyte specification and differentiation in the ventral spinal cord.
MAFA (show MAFA Antibodies), MAFB (show MAFB Antibodies), NKX6.1, and PDX1 (show PDX1 Antibodies) activity provides a gauge of islet beta cell function, with loss of MAFA (show MAFA Antibodies) (and/or MAFB (show MAFB Antibodies)) representing an early indicator of beta cell inactivity
Over time, Nkx6.1-deficient beta cells acquired molecular characteristics of delta cells, revealing a molecular link between impaired beta cell functional properties and loss of cell identity.
Our findings establish Nkx6.1 as a beta (show SUCLA2 Antibodies) cell programming factor and demonstrate that repression of alternative lineage programs is a fundamental principle by which beta cells are specified and maintained.
Data found direct binding of RBP (show RBP4 Antibodies)-jkappa to the Nkx6.1 proximal promoter.
Results demonstrate that sustained Nkx6.1 overexpression in vivo does not stimulate beta-cell proliferation, expand beta-cell mass, or improve glucose metabolism in either normal or beta-cell-depleted pancreata.
Nkx6 genes pattern the frog neural plate and Nkx6.1 is necessary for motoneuron axon projection.
Data show a longitudinal domain positive for both Nkx6.1 and Nkx6.2 that is medial to the Pou4f1 (show POU4F1 Antibodies)-positive red nucleus. This domain could correspond to part of the reticular formation, which extends from the diencephalon and the mesencephalon.
Ependymal cells in adult spinal cord are derived from Nkx6.1+ ventral neural progenitor cells. Nkx6.1+ ependymal cells in adult mouse spinal cords may retain the proliferative property of neural stem cells.
Results demonstrate a requirement for Nkx6.1 in the development of postmitotic motoneurons, and suggest a cell-autonomous function in the control of branchio-motoneuron migration.
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004)
NK6 transcription factor related, locus 1
, NK6 homeobox 1
, NK homeo box, family 6, member A
, NK homeobox, family 6, A
, NK6 transcription factor homolog A
, homeobox protein NK-6 homolog A
, homeobox protein Nkx-6.1
, NK6 transcription factor related locus 1
, Drosophila NK transcription factor related, gene family 6, locus 1
, homeodomain transcription factor Nkx6.1