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NK6 Homeobox 1 Proteins (NKX6-1)

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. Additionally we are shipping NK6 Homeobox 1 Antibodies (84) and NK6 Homeobox 1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NKX6-1 4825 P78426
NKX6-1 18096 Q99MA9
NKX6-1 65193 O35762
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Top NK6 Homeobox 1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,999.33
Details

NKX6-1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

Rat (Rattus)

More Proteins for NK6 Homeobox 1 (NKX6-1) Interaction Partners

Human NK6 Homeobox 1 (NKX6-1) interaction partners

  1. a significant relationship was observed between NKX6.1 and EMT (show ITK Proteins) marker expression levels, and NKX6.1 knockdown inhibited cell invasion, and overexpression of NKX6.1 promotes cell proliferation in vitro.

  2. study evaluated the potential use of NKX6-1 as a diagnostic marker for well-differentiated neuroendocrine tumors

  3. NKX6-1 reveals wide variations in methylation levels in normal control samples of cervical adenocarcinomas.

  4. Mice transplanted with NKX6.1-low cells remained hyperglycemic throughout the 5-month post-transplant period whereas diabetes was reversed in NKX6.1-high recipients within 3 months.

  5. MAFA (show KLRG1 Proteins), MAFB (show MAFB Proteins), NKX6.1, and PDX1 (show PDX1 Proteins) activity provides a gauge of islet beta cell function, with loss of MAFA (show KLRG1 Proteins) (and/or MAFB (show MAFB Proteins)) representing an early indicator of beta cell inactivity

  6. Smooth muscle cells expressing nestin (show NES Proteins) and Nkx6.1 are the main cell population derived from culturing human spinal cord cells in adherent conditions with serum.

  7. Data suggest that NKX6.1 activates immature pancreatic markers but not pancreatic hormone (show PPY Proteins) gene expression in human liver cells, and suggest a potential role for NKX6.1 in promoting PDX-1 (show PDX1 Proteins) reprogrammed maturation along a beta (show SUCLA2 Proteins)-cell-like lineage.

  8. identified an NKX6.1 recognition sequence in the distal region of the HNF1alpha (show HNF1A Proteins) promoter and demonstrated specific binding of NKX6.1 in beta cells

  9. Nkx6.1 is a bifunctional transcription factor that serves to maintain the specific expression of its own gene during beta-cell differentiation while simultaneously effecting broader gene repression events

  10. overexpression of Nkx6.1 in islets caused an increase in the level of [(3)H]thymidine incorporation that was twice the control level, along with complete retention of glucose-stimulated insulin (show INS Proteins) secretion

Zebrafish NK6 Homeobox 1 (NKX6-1) interaction partners

  1. nkx6.1 regulates the alpha- and beta-cell formation in zebrafish by acting on the stem cells in the Islets of Langerhans.

  2. In zebrafish, Nkx6.1 is expressed in early-born primary and later-born secondary motoneurons

  3. Study shows that zebrafish primary motoneurons express two related transcription factors Nkx6.1 and Nkx6.2; in their absence, the CaP motoneuron subtype develops normally, whereas the MiP motoneuron subtype develops a interneuron-like morphology.

Xenopus laevis NK6 Homeobox 1 (NKX6-1) interaction partners

  1. The results suggest that Nkx6.1 is involved in mid-hindbrain formation in Xenopus embryos, likely by modulating wnt1 (show WNT1 Proteins) expression.

  2. Nkx6.1 and Nkx6.2 share overlapping expression domains in the ventral neural tube at neurula stages and later in the ventral part of developing hindbrain and spinal cord. Nkx6.3 (show NKX6-3 Proteins) is detected in the non-neural ectoderm.

Mouse (Murine) NK6 Homeobox 1 (NKX6-1) interaction partners

  1. Nkx6.1 plays a vital role in astrocyte specification and differentiation in the ventral spinal cord.

  2. MAFA (show MAFA Proteins), MAFB (show MAFB Proteins), NKX6.1, and PDX1 (show PDX1 Proteins) activity provides a gauge of islet beta cell function, with loss of MAFA (show MAFA Proteins) (and/or MAFB (show MAFB Proteins)) representing an early indicator of beta cell inactivity

  3. Over time, Nkx6.1-deficient beta cells acquired molecular characteristics of delta cells, revealing a molecular link between impaired beta cell functional properties and loss of cell identity.

  4. Our findings establish Nkx6.1 as a beta (show SUCLA2 Proteins) cell programming factor and demonstrate that repression of alternative lineage programs is a fundamental principle by which beta cells are specified and maintained.

  5. Data found direct binding of RBP (show RBP4 Proteins)-jkappa to the Nkx6.1 proximal promoter.

  6. Results demonstrate that sustained Nkx6.1 overexpression in vivo does not stimulate beta-cell proliferation, expand beta-cell mass, or improve glucose metabolism in either normal or beta-cell-depleted pancreata.

  7. Nkx6 genes pattern the frog neural plate and Nkx6.1 is necessary for motoneuron axon projection.

  8. Data show a longitudinal domain positive for both Nkx6.1 and Nkx6.2 that is medial to the Pou4f1 (show POU4F1 Proteins)-positive red nucleus. This domain could correspond to part of the reticular formation, which extends from the diencephalon and the mesencephalon.

  9. Ependymal cells in adult spinal cord are derived from Nkx6.1+ ventral neural progenitor cells. Nkx6.1+ ependymal cells in adult mouse spinal cords may retain the proliferative property of neural stem cells.

  10. Results demonstrate a requirement for Nkx6.1 in the development of postmitotic motoneurons, and suggest a cell-autonomous function in the control of branchio-motoneuron migration.

NK6 Homeobox 1 (NKX6-1) Protein Profile

Protein Summary

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004)

Gene names and symbols associated with NK6 Homeobox 1 Proteins (NKX6-1)

  • NK6 homeobox 1 (nkx6-1)
  • NK6 homeobox 1 (NKX6-1)
  • NK6 homeobox 1 (nkx6.1)
  • NK6 homeobox 1 (Nkx6-1)
  • Nkx6.1 protein
  • Nkx6a protein
  • Nkx61 protein
  • zgc:92879 protein

Protein level used designations for NK6 Homeobox 1 Proteins (NKX6-1)

NK6 transcription factor related, locus 1 , NK6 homeobox 1 , NK homeo box, family 6, member A , NK homeobox, family 6, A , NK6 transcription factor homolog A , homeobox protein NK-6 homolog A , homeobox protein Nkx-6.1 , NK6 transcription factor related locus 1 , Drosophila NK transcription factor related, gene family 6, locus 1 , homeodomain transcription factor Nkx6.1

GENE ID SPECIES
549337 Xenopus (Silurana) tropicalis
706844 Macaca mulatta
4825 Homo sapiens
436748 Danio rerio
100101340 Xenopus laevis
487838 Canis lupus familiaris
616211 Bos taurus
18096 Mus musculus
65193 Rattus norvegicus
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