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anti-NLR Family, CARD Domain Containing 4 (NLRC4) Antibodies

In C. Additionally we are shipping NLRC4 Kits (8) and NLRC4 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NLRC4 58484 Q9NPP4
NLRC4 268973  
NLRC4 298784  
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Top anti-NLRC4 Antibodies at antibodies-online.com

Showing 10 out of 91 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, WB WB Suggested Anti-NLRC4 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IF, WB Immunocytochemistry of Ipaf in THP-1 cells with AP30437PU-N Ipaf antibody at 10 μg/ml. Western blot analysis of Ipaf in human PBL lysate with AP30437PU-N Ipaf antibody at 0.5 (lane A), 1 (lane B), and 2 (lane C) μg/ml, respectively. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB NLRC4 Antibody (N-term) (ABIN657230) western blot analysis in MDA-MB231 cell line lysates (35 µg/lane). This demonstrates the NLRC4 antibody detected the NLRC4 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Image CARD12 antibody detects CARD12 protein by western blot analysis. Non-transfected (-) and CARD12 -transfected (+,) 293T whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with CARD12 antibody , diluted by 1:5000. WB Image Sample (30 ug of whole cell lysate) A: MCF-7 5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (fro), IHC (p), IP, WB 50 μL Log in to see 8 to 10 Days
$507.83
Details
Human Mouse Un-conjugated FACS 100 μg Log in to see 10 to 12 Days
$244.59
Details
Human Rabbit Un-conjugated ICC, IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with NLRC4 antibody ABIN214456 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details

NLRC4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-NLRC4 Antibodies

  1. Human Monoclonal NLRC4 Primary Antibody for FACS - ABIN2665296 : Cai, Batra, Wakamatsu, Pacher, Jeyaseelan: NLRC4 inflammasome-mediated production of IL-1β modulates mucosal immunity in the lung against gram-negative bacterial infection. in Journal of immunology (Baltimore, Md. : 1950) 2012 (PubMed)
    Show all 5 references for ABIN2665296

  2. Human Polyclonal NLRC4 Primary Antibody for EIA, IF - ABIN500034 : Poyet, Srinivasula, Tnani, Razmara, Fernandes-Alnemri, Alnemri: Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. in The Journal of biological chemistry 2001 (PubMed)
    Show all 3 references for ABIN500034

  3. Human Polyclonal NLRC4 Primary Antibody for IHC, WB - ABIN2792097 : Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ... in Genome research 2003 (PubMed)

  4. Human Polyclonal NLRC4 Primary Antibody for WB - ABIN657230 : Vinzing, Eitel, Lippmann, Hocke, Zahlten, Slevogt, Nguessan, Günther, Schmeck, Hippenstiel, Flieger, Suttorp, Opitz: NAIP and Ipaf control Legionella pneumophila replication in human cells. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)

More Antibodies against NLRC4 Interaction Partners

Human NLR Family, CARD Domain Containing 4 (NLRC4) interaction partners

  1. association of IL-18 (show IL18 Antibodies) levels with a single nucleotide polymorphism in the untranslated exon 2 of the inflammasome component NLRC4

  2. While both contributing to pathogen clearance, NLRP3 (show NLRP3 Antibodies) more than NLRC4 contributes to deleterious inflammatory responses in cystic fibrosis (show S100A8 Antibodies) and correlates with defective NLRC4-dependent IL-1Ra (show IL1RN Antibodies) production.

  3. analysis of a subset of inflammasome receptors including NLRP3 (show NLRP3 Antibodies), NLRC4 and AIM2 (show AIM2 Antibodies) that triggers formation of the micrometer-sized spherical supramolecular complex called the ASC (show PYCARD Antibodies) speck

  4. Thus, pathogenic inflammasome activity during Candida infection is negatively regulated by the IL-22 (show IL22 Antibodies)/NLRC4/IL-1Ra (show IL1RN Antibodies) axis.

  5. cN-II (show NT5C2 Antibodies) co-immunoprecipitated both with wild type Ipaf and its LRR domain after transfection with corresponding expression vectors, but not with Ipaf lacking the LRR domain.

  6. Elevated expression of IPAF was associated with inflammation in patients with pemphigus vulgaris (show DSG3 Antibodies) disease.

  7. Data indicate that NLR family CARD domain containing 4 protein (NLRC4) is a causative gene for familial cold autoinflammatory syndrome (FCAS).

  8. Data show that the disease was caused by a de novo gain-of-function mutation in NLR family CARD domain containing 4 (NLRC4) encoding a p.Val341Ala substitution.

  9. inflammasome (also known as NLRC4) has been demonstrated to play a role in host defense mechanisms against pathogen-associated molecules

  10. This review describes the surprisingly diverse mechanisms by which NLRC4 senses bacteria and initiates innate immune responses.

Mouse (Murine) NLR Family, CARD Domain Containing 4 (NLRC4) interaction partners

  1. While both contributing to pathogen clearance, NLRP3 (show NLRP3 Antibodies) more than NLRC4 contributes to deleterious inflammatory responses in cystic fibrosis (show S100A8 Antibodies) and correlates with defective NLRC4-dependent IL-1Ra (show IL1RN Antibodies) production.

  2. The wheel-like structure of a PrgJ-NAIP2-NLRC4 complex determined by cryogenic electronmicroscopy at 6.6 angstrom reveals that NLRC4 activation involves substantial structural reorganization that creates one oligomerization surface (catalytic surface).

  3. caspase-1 (show CASP1 Antibodies) is activated in macrophages under hypertonic conditions through NLRP3 (show NLRP3 Antibodies) and NLRC4 inflammasome activation.

  4. These results show that NLRC4 and TLR5 (show TLR5 Antibodies), key components of two flagellin (show FliC Antibodies) sensing pathways, each contribute to host defense in respiratory melioidosis.

  5. Data show that caspase-1 (show CASP1 Antibodies) but not caspase-11 (show CASP4 Antibodies) was essential for the functional activities of the NLRC4 inflammasome.

  6. TLR4 (show TLR4 Antibodies) activation induces IL-1beta (show IL1B Antibodies) release via an IPAF dependent but caspase 1 (show CASP1 Antibodies)/11/8 independent pathway in the lung.

  7. The present findings demonstrated that mice deficient in NLRC4 or ASC (show STS Antibodies), but not in NLRP3 (show NLRP3 Antibodies), present reduced mechanical and thermal acute inflammatory hyperalgesia induced by carrageenan

  8. AIM2 (show AIM2 Antibodies) and NLRC4 inflammasomes contribute with ASC (show STS Antibodies) to acute brain injury independently of NLRP3 (show NLRP3 Antibodies)

  9. Data indicate that transgenic mice that expressed mutant NLR family CARD domain containing 4 protein (NLRC4) developed dermatitis and arthritis.

  10. revealed that beta-arrestin1 (show ARRB1 Antibodies) specifically interacted with NLRP3 (show NLRP3 Antibodies) and NLRC4 and promoted their self-oligomerization

NLRC4 Antigen Profile

Protein Summary

In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.

Gene names and symbols associated with NLRC4

  • NLR family, CARD domain containing 4 (NLRC4) antibody
  • NLR family, CARD domain containing 4 (Nlrc4) antibody
  • 9530011P19Rik antibody
  • Card12 antibody
  • CLAN antibody
  • CLAN1 antibody
  • CLANA antibody
  • CLANB antibody
  • CLANC antibody
  • CLAND antibody
  • CLR2.1 antibody
  • IPAF antibody

Protein level used designations for NLRC4

caspase recruitment domain protein 12 , NLR family CARD domain-containing protein 4 , ice protease-activating factor , ipaf , NLR family, CARD domain containing 4 , CARD, LRR, and NACHT-containing protein , ICE-protease activating factor , NOD-like receptor C4 , caspase recruitment domain family, member 12 , caspase recruitment domain-containing protein 12 , nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4

GENE ID SPECIES
459135 Pan troglodytes
512480 Bos taurus
706378 Macaca mulatta
100070605 Equus caballus
58484 Homo sapiens
268973 Mus musculus
298784 Rattus norvegicus
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