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NLRC5 encodes a member of the caspase recruitment domain-containing NLR family.
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The NLRC5 transcript in pigs is relatively conservative among mammals and may play a vital role in immune reaction, which provides a basis for further studies on the NLRC5 function in the pig immune system and the role in comparative immunity.
NLRC5 interacts with miR (show MLXIP Antibodies)-34a.NLRC5 role in HPV16 persistence.
These results demonstrate that NLRC5 promotes hepatocellular carcinoma progression via the AKT (show AKT1 Antibodies)/VEGF-A (show VEGFA Antibodies) signaling pathway
NLRC5 not only positively correlates with the increase of beta-catenin (show CTNNB1 Antibodies) but also coordinates the activation of downstream Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway, regulating cell proliferation, migration and invasion in hepatocellular carcinoma.
silencing NLRC5 reduced extracellular matrix expression in keloid fibroblasts through inhibiting the TGF-beta1 (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signaling pathway.
CITA/NLRC5 and CIITA are transcriptional regulators that orchestrate the concerted expression of critical components in the MHC class I and class II pathways, respectively. [review]
NLRC5 expression was significantly associated with the activation of CD8 (show CD8A Antibodies)(+) cytotoxic T cells and patient survival in multiple cancer types. Thus, NLRC5 constitutes a novel prognostic biomarker and potential therapeutic target of cancers.
NLRC5 regulates TGFB1 (show TGFB1 Antibodies)-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis.
In a transformed cell line, NLRC5 plays a significant role in IL-6 (show IL6 Antibodies) and IL-1Beta (show IL1B Antibodies) secretion.
NLRC5 function is shaped by reversible ubiquitination, which modulates the NF-kappaB (show NFKB1 Antibodies) activation switch
RSV infection of lung epithelial cells induces expression of RIG-I, NLRC5, and subsequent upregulation of HLA-A, HLA-B and HLA-C.
NLRC5 knockout in mice exhibited greater hepatic injury after hepatic ischemia/reperfusion (I/R) injury.
The observed increases in viral titers in NLRC5-deficient mice correlated with impaired effector CD8 (show CD8A Antibodies)(+) T cell responses. Although NLRC5-deficient mice were defective at clearing the virus, they did not show an increase in morbidity or mortality following influenza virus infection because of other compensatory immune mechanisms.
NLRC5 is differentially expressed in hepatic tissues and hepatic stellate cells during hepatic fibrosis and its reversal
NLRC5 expression in T cells is required to protect them from NK-cell-mediated elimination upon inflammation.
NLRC5 and CIITA (show CIITA Antibodies) thus emerge as paradigms for a novel class of transcriptional regulators dedicated for transactivating extremely few, phylogenetically related genes.
Unusual structural features revealed by the solution NMR structure of the NLRC5 caspase (show CASP3 Antibodies) recruitment domain.
Data conclude that Nlrc5 is important in the regulation of MHC-I expression by reducing H3K27me3 on MHC-I promoter and joins CIITA as an NLR subfamily that controls MHC gene transcription.
NLRC5 is required for both constitutive and inducible histocompatibility class I gene expression and host defense.
NLRC5 ablation reduces MHC class I expression, and enhances IKK (show CHUK Antibodies) and IRF3 (show IRF3 Antibodies) phosphorylation in response to TLR stimulation or viral infection.
This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways.
NLR family, CARD domain containing 5
, protein NLRC5
, NOD-like receptor C5
, caterpiller protein 16.1
, nucleotide-binding oligomerization domain protein 4
, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5
, nucleotide-binding oligomerization domains 27