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NLRP1 encodes a member of the Ced-4 family of apoptosis proteins. Additionally we are shipping and and many more products for this protein.
Showing 10 out of 74 products:
Human Polyclonal NLRP1 Primary Antibody for EIA, IF - ABIN500310
Tschopp, Martinon, Burns: NALPs: a novel protein family involved in inflammation. in Nature reviews. Molecular cell biology 2003
Show all 4 references for ABIN500310
Human Polyclonal NLRP1 Primary Antibody for IF, IHC (p) - ABIN303286
Hlaing, Guo, Dilley, Loussia, Morrish, Shi, Vincenz, Ward: Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins. in The Journal of biological chemistry 2001
Show all 3 references for ABIN303286
Human Polyclonal NLRP1 Primary Antibody for WB - ABIN2785731
Fahy, Exline, Gavrilin, Bhatt, Besecker, Sarkar, Hollyfield, Duncan, Nagaraja, Knatz, Hall, Wewers: Inflammasome mRNA expression in human monocytes during early septic shock. in American journal of respiratory and critical care medicine 2008
Human Monoclonal NLRP1 Primary Antibody for ICC, IF - ABIN4340089
Kummer, Broekhuizen, Everett, Agostini, Kuijk, Martinon, van Bruggen, Tschopp: Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007
NLRP1 inflammasome is activated by extracellular acidosis through ASIC1a (show ACCN2 Antibodies) signal pathway.
Nlrp1 inflammasome is downregulated in trauma patients
Human central Nervous System neurons express NLRP1 inflammasomes, which activate Casp1 (show CASP1 Antibodies) and subsequently Casp6 (show CASP6 Antibodies). Casp1 (show CASP1 Antibodies) activation generates interleukin-1-beta (show IL1B Antibodies)-mediated neuroinflammation and Casp6 (show CASP6 Antibodies) activation causes axonal degeneration.
The data of this study suggested that NLRP1/caspase-1 (show CASP1 Antibodies) signaling participates in the seizure-induced degenerative process in humans.
The NLRP1 variant rs12150220 (L155H) was associated with the development of preeclampsia (OR = 1.58), suggesting a role of this inflammasome receptor in the pathogenesis of this multifactorial disorder.
Elevated expression of NLRP1 was associated with pemphigus vulgaris (show DSG3 Antibodies) disease progression.
Ethanol-induced HMGB1 (show HMGB1 Antibodies) release is associated with NOX2 (show CYBB Antibodies)/NLRP1 inflammasome signaling, which represents a novel mechanism of ethanol-associated neuron injury.
NALP1 is expressed low in colon cancer and associated with the survival and tumor metastasis of patients, and treatment with 5-aza-2-deoxycytidine can restore NALP1 levels to suppress the growth of colon cancer.
Our data support the involvement of NLRP1 and the NLRP1 inflammasome in psoriasis susceptibility and further support the role of innate immunity in psoriasis.
these data identify NLRP1 as an essential mediator of the host immune response during IBD and cancer.
NLRP1 is an innate immune sensor that functions in the context of metabolic stress to produce IL-18 (show IL18 Antibodies), preventing obesity and metabolic syndrome.
Data show that eicosanoid 15-deoxy-Delta(12,14)-PGJ2 (15d-PGJ2) and related cyclopentenone PGs inhibit caspase-1 (show CASP1 Antibodies) activation by the NLR (show CXCR5 Antibodies) family leucine-rich repeat protein (show LRRC10 Antibodies) (NLRP)1 and NLRP3 (show NLRP3 Antibodies) inflammasomes.
The NOD-like receptor NLRP1a/Caspase-1 (show CASP1 Antibodies) pathway is the best candidate to mediate the parasite-induced cell death.
Caspase-8 (show CASP8 Antibodies) promotes NLRP1/NLRP3 (show NLRP3 Antibodies) inflammasome activation and IL-1beta (show IL1B Antibodies) production in acute glaucoma.
These findings reveal Toxoplasma gondii as a novel activator of the NLRP1 and NLRP3 (show NLRP3 Antibodies) inflammasomes in vivo and establish a role for these sensors in host resistance to toxoplasmosis.
Arsenicals, including arsenic trioxide and sodium arsenite, inhibited activation of the NLRP1, NLRP3 (show NLRP3 Antibodies), and NAIP5/NLRC4 (show NLRC4 Antibodies) inflammasomes.
the NLRP1 and NLRP3 (show NLRP3 Antibodies) inflammasomes have a major role in neuronal cell death and behavioral deficits in stroke.
data indicate that NLRP1 is an innate immune sensor for Toxoplasma infection, activated via a novel mechanism that corresponds to a host-protective innate immune response to the parasite.
sequencing of expressed Nlrp1a showed the protein to be highly conserved across all mouse strains. We found that Nlrp1a was expressed only in toxin-resistant macrophages, with the sole exception of expression in LT-sensitive CAST/EiJ macrophages
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
NACHT, leucine rich repeat and PYD containing 1
, NLR family protein 1
, NLR family, pyrin domain containing 1
, resistant anthrax lethal toxin
, NACHT, LRR and PYD domains-containing protein 1
, NLR family pyrin domain containing 1
, NACHT, LRR and PYD containing protein 1
, NACHT, leucine rich repeat and PYD (pyrin domain) containing 1
, caspase recruitment domain protein 7
, caspase recruitment domain-containing protein 7
, death effector filament-forming Ced-4-like apoptosis protein
, nucleotide-binding domain and caspase recruitment domain
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1
, NACHT/LRR/pyrin domain-containing protein 1
, caspase recruitment domain protein