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anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) Antibodies

NLRP1 encodes a member of the Ced-4 family of apoptosis proteins. Additionally we are shipping and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NLRP1 360557  
NLRP1 22861 Q9C000
NLRP1 195046  
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Top anti-NLRP1 Antibodies at antibodies-online.com

Showing 10 out of 75 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-NLRP1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: NCI-H226 cell lysate WB Suggested Anti-NLRP1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: NCI-H226 cell lysate.NLRP1 is strongly supported by BioGPS gene expression data to be expressed in NCI-H226 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IF, WB Immunocytochemistry of NALP1 in K562 cells with this product at 10 μg/ml. Western blot analysis of NALP1 in U937 cell lysate with this product at (A) 1, (B) 2 and (C) 4 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated ICC, IF, IHC, IHC (fro), IHC (p), IP, WB NLRP1/NALP1 Antibody (Nalpy1-4) [NBP1-97593] - Analysis of the time course of assembly of the inflammasome using MAb to NLRP1/NALP1 (Nalpy1-4) in THP-1 macrophages. Method: Assembly of the inflammasome was induced by shifting the temperature to 30C after hypotonic lysis. THP-1 cell extracts were immunoprecipitated using PAb to Asc (AL177) and run on SDS-PAGE. NLRP1/NALP1 was detected by MAb to NALP1 (Nalpy1-4) at 1:1000 dilution. Anti-mouse IgG coupled horse radish peroxidase was used at 1:5000 dilution for ECL detection. For more information about the 'time course assembly of inflammasome' method see F. Martinon; Mol. Cell. 10, 417 (2002). Immunocytochemistry/Immunofluorescence: NALP1 Antibody (Nalpy1-4) [NBP1-97593] - Detection of NLRP1/NALP1 in 293T cells transfected with a human NLRP1/NALP1 expression plasmid. Left: Phase contrast. Right: Staining with MAb to NLRP1/NALP1 (Nalpy1-4).Method: 293T cells transfected with full length human NLRP1/NALP1 were fixed with 4% paraformaldehyde and stained with 1ug/ml MAb to NLRP1/NALP1 (Nalpy1-4) and then Alexa 488 (1:300 dilution). 0.05 mg Log in to see 6 to 9 Days
$381.94
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (fro), WB Western Blot: NLRP1/NALP1 Antibody [NBP1-54899] - Human Fetal Brain, Antibody Dilution: 1.0 ug/ml. Western Blot: NLRP1/NALP1 Antibody [NBP1-54899] - NCI-H226 cell lysate, concentration 0.2-1 ug/ml. 100 μL Log in to see 5 to 7 Days
$500.06
Details
Human Rabbit Un-conjugated IHC (p), WB Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated IHC (fro), IHC (p), IP, WB 50 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated IHC (fro), IHC (p), IP, WB 50 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated WB Western blot analysis of human and mouse cell lines using anti-human NLRP1/NALP1 antibody (AL176) .  Method: Total protein extracts (20μg) from various human (293-T, Jurkat, Raj, Ramos, BJAB, THP-1, U937, K562, Raw, HeLa) and mouse (EL-4, A20) cell lines were run on SDS-PAGE and NLRP1/NALP1 detected using anti-human NLRP1/NALP1 antibody (AL176) at 1:500 dilution. Anti-rabbit IgG coupled horse radish peroxidase was used at 1:5000 dilution for ECL detection. 100 μg Log in to see 5 to 8 Days
$357.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: NLRP1/NALP1 Antibody [NBP1-02627] - Staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 0.05 mg Log in to see 8 to 11 Days
$447.56
Details

NLRP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-NLRP1 Antibodies

  1. Human Polyclonal NLRP1 Primary Antibody for ICC, IF - ABIN4890403 : Fahy, Exline, Gavrilin, Bhatt, Besecker, Sarkar, Hollyfield, Duncan, Nagaraja, Knatz, Hall, Wewers: Inflammasome mRNA expression in human monocytes during early septic shock. in American journal of respiratory and critical care medicine 2008 (PubMed)
    Show all 4 references for ABIN4890403

  2. Human Polyclonal NLRP1 Primary Antibody for EIA, IF - ABIN500310 : Tschopp, Martinon, Burns: NALPs: a novel protein family involved in inflammation. in Nature reviews. Molecular cell biology 2003 (PubMed)
    Show all 4 references for ABIN500310

  3. Human Polyclonal NLRP1 Primary Antibody for IF, IHC (p) - ABIN303286 : Hlaing, Guo, Dilley, Loussia, Morrish, Shi, Vincenz, Ward: Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins. in The Journal of biological chemistry 2001 (PubMed)
    Show all 3 references for ABIN303286

  4. Human Monoclonal NLRP1 Primary Antibody for ICC, IF - ABIN4340089 : Kummer, Broekhuizen, Everett, Agostini, Kuijk, Martinon, van Bruggen, Tschopp: Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007 (PubMed)

More Antibodies against NLRP1 Interaction Partners

Human NLR Family, Pyrin Domain Containing 1 (NLRP1) interaction partners

  1. Simvastatin intake in peripheral arterial disease patients increases in vitro reactivity of NLRP1 inflammasome gene expression in endothelial cells.

  2. these findings establish a group of non-fever inflammasome disorders, uncover an unexpected auto-inhibitory function for the pyrin (show MEFV Antibodies) domain, and provide the first genetic evidence linking NLRP1 to skin inflammatory syndromes and skin cancer predisposition.

  3. The NLRP3 (show NLRP3 Antibodies) and NLRP1 inflammasomes are activated in Alzheimer's disease

  4. NLRP1 inflammasome is activated by extracellular acidosis through ASIC1a (show ACCN2 Antibodies) signal pathway.

  5. Nlrp1 inflammasome is downregulated in trauma patients

  6. Human central Nervous System neurons express NLRP1 inflammasomes, which activate Casp1 (show CASP1 Antibodies) and subsequently Casp6 (show CASP6 Antibodies). Casp1 (show CASP1 Antibodies) activation generates interleukin-1-beta (show IL1B Antibodies)-mediated neuroinflammation and Casp6 (show CASP6 Antibodies) activation causes axonal degeneration.

  7. The data of this study suggested that NLRP1/caspase-1 (show CASP1 Antibodies) signaling participates in the seizure-induced degenerative process in humans.

  8. The NLRP1 variant rs12150220 (L155H) was associated with the development of preeclampsia (OR = 1.58), suggesting a role of this inflammasome receptor in the pathogenesis of this multifactorial disorder.

  9. Elevated expression of NLRP1 was associated with pemphigus vulgaris (show DSG3 Antibodies) disease progression.

  10. Ethanol-induced HMGB1 (show HMGB1 Antibodies) release is associated with NOX2 (show CYBB Antibodies)/NLRP1 inflammasome signaling, which represents a novel mechanism of ethanol-associated neuron injury.

Mouse (Murine) NLR Family, Pyrin Domain Containing 1 (NLRP1) interaction partners

  1. The findings indicate that NLRP1 inflammasome activation does not significantly contribute to acute neural injury in the murine model of moderate CCI injury.

  2. the aim of this study was to evaluate the effects of chronic dexamethasone (DEX) treatment on nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 1 (show PYDC1 Antibodies) (NLRP-1) inflammasome in male mice.

  3. NLRP1 is an innate immune sensor that functions in the context of metabolic stress to produce IL-18 (show IL18 Antibodies), preventing obesity and metabolic syndrome.

  4. these data identify NLRP1 as an essential mediator of the host immune response during IBD and cancer.

  5. Data show that eicosanoid 15-deoxy-Delta(12,14)-PGJ2 (15d-PGJ2) and related cyclopentenone PGs inhibit caspase-1 (show CASP1 Antibodies) activation by the NLR (show CXCR5 Antibodies) family leucine-rich repeat protein (show LRRC10 Antibodies) (NLRP)1 and NLRP3 (show NLRP3 Antibodies) inflammasomes.

  6. The NOD-like receptor NLRP1a/Caspase-1 (show CASP1 Antibodies) pathway is the best candidate to mediate the parasite-induced cell death.

  7. Caspase-8 (show CASP8 Antibodies) promotes NLRP1/NLRP3 (show NLRP3 Antibodies) inflammasome activation and IL-1beta (show IL1B Antibodies) production in acute glaucoma.

  8. These findings reveal Toxoplasma gondii as a novel activator of the NLRP1 and NLRP3 (show NLRP3 Antibodies) inflammasomes in vivo and establish a role for these sensors in host resistance to toxoplasmosis.

  9. Arsenicals, including arsenic trioxide and sodium arsenite, inhibited activation of the NLRP1, NLRP3 (show NLRP3 Antibodies), and NAIP5/NLRC4 (show NLRC4 Antibodies) inflammasomes.

  10. the NLRP1 and NLRP3 (show NLRP3 Antibodies) inflammasomes have a major role in neuronal cell death and behavioral deficits in stroke.

NLRP1 Antigen Profile

Protein Summary

This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.

Gene names and symbols associated with NLRP1

  • NLR family, pyrin domain containing 1A (Nlrp1a) antibody
  • NLR family, pyrin domain containing 1 (NLRP1) antibody
  • CARD7 antibody
  • CIDED antibody
  • CLR17.1 antibody
  • DEFCAP antibody
  • DEFCAP-L/S antibody
  • Gm14 antibody
  • Gm15 antibody
  • NAC antibody
  • NALP1 antibody
  • Nalp1a antibody
  • Nlrp1 antibody
  • PP1044 antibody
  • SLEV1 antibody
  • VAMAS1 antibody

Protein level used designations for NLRP1

NACHT, leucine rich repeat and PYD containing 1 , NLR family protein 1 , NLR family, pyrin domain containing 1 , resistant anthrax lethal toxin , NACHT, LRR and PYD domains-containing protein 1 , NLR family pyrin domain containing 1 , NACHT, LRR and PYD containing protein 1 , NACHT, leucine rich repeat and PYD (pyrin domain) containing 1 , caspase recruitment domain protein 7 , caspase recruitment domain-containing protein 7 , death effector filament-forming Ced-4-like apoptosis protein , nucleotide-binding domain and caspase recruitment domain , nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1 , NACHT/LRR/pyrin domain-containing protein 1 , caspase recruitment domain protein

GENE ID SPECIES
360557 Rattus norvegicus
489449 Canis lupus familiaris
721648 Macaca mulatta
100412129 Callithrix jacchus
100481297 Ailuropoda melanoleuca
100607186 Nomascus leucogenys
22861 Homo sapiens
195046 Mus musculus
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