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Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Additionally we are shipping and many more products for this protein.
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Human Polyclonal NLRP10 Primary Antibody for EIA, WB - ABIN783715
Tschopp, Martinon, Burns: NALPs: a novel protein family involved in inflammation. in Nature reviews. Molecular cell biology 2003
Show all 2 references for ABIN783715
Review summarize recent advances of the role of of human and murine NLRP10 in innate and adaptive immune responses. [Review]
These data revealed a novel role of NLRP10 in innate immune responses towards bacterial infection and suggest that NLRP10 functions as a scaffold for the formation of the NOD1 (show NOD1 Antibodies)-Nodosome.
The results show that either deletion of the p53 (show TP53 Antibodies) binding elements within the PYNOD promoter or treatment with p53 (show TP53 Antibodies) inhibitor could significantly reduce PYNOD promoter activity.
Transgenic PYNOD colocalizes (show IL1B Antibodies) with apoptosi (show TNF Antibodies)s-associated speck-like protein containing a caspase recruitment domain (ASC) and inhibits caspase-1-mediated interleukin (IL)-1beta p (show CASP3 Antibodies)rocessing without inhibiting caspase-4-mediated caspase-1 processing.
PYNOD is a novel regulator of apoptosis and inflammation.
PYPAF3 (show NLRP7 Antibodies) is a feedback regulator of interleukin-1beta secretion, and PYPAF2 (show NLRP2 Antibodies) and PYPAF3 (show NLRP7 Antibodies), together with PYNOD, constitute an anti-inflammatory subgroup of PYRIN (show MEFV Antibodies)-containing apoptotic protease-activating factor-1-like (show APAF1 Antibodies) proteins
The structural modification of the NLRP10 gene might have played a role in development or enhancement of human-specific traits during evolution.
conclude that DOCK8 (show DOCK8 Antibodies) is an important regulator of DC migration during an immune response and is prone to mutations that disrupt its crucial function
Nlrp10-deficient mice displayed a profound defect in Candida-specific Th1 (show HAND1 Antibodies) and Th17 responses. These results demonstrate a novel role for Nlrp10 in the generation of adaptive immune responses to fungal infection.
loss of antigen transport to the draining lymph nodes by a subset of migratory dendritic cells resulted in an almost absolute loss in naive CD4 (show CD4 Antibodies)( ) T-cell priming, highlighting the critical link between diverse innate immune stimulation, NLRP10 activity and the immune function of mature DCs
Serum interleukin (IL)-1beta (show IL1B Antibodies) and TNF-alpha (show TNF Antibodies) after lipopolysaccharide injection are decreased in PYNOD-transgenic and apoptosis-associated speck-like protein containing a caspase (show CASP3 Antibodies) recruitment domain knockout mice compared with those of wild-type mice.
Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis.
NLR family, pyrin domain containing 10
, NACHT, LRR and PYD domains-containing protein 10
, NACHT, leucine rich repeat and PYD containing 10
, nucleotide-binding oligomerization domain protein 8
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10
, NACHT, LRR and PYD containing protein 10
, NACHT/LRR/pyrin domain-containing protein 10
, neuronal apoptosis inhibitor protein 10