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The protein encoded by NLRP14 belongs to the NALP protein family. Additionally we are shipping NLR Family, Pyrin Domain Containing 14 Antibodies (15) and and many more products for this protein.
Nalp14 transcripts were continuously expressed through the preovulatory stage, but declined when meiotic maturation resumed, and they were markedly diminished by the 2-cell embryo stage.
Data show that NLRP14 expression was rapidly downregulated after fertilization.
This study describes conformational stability of native NLRP14 and mutants in their monomeric and dimeric states and compares them to NLRP4, a representative of a native pyrin (show MEFV ELISA Kits) domain fold.
Our data suggest that NALP14 has a function in spermatogenesis and that mutations in this gene might cause spermatogenic failure.
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5.
NACHT, LRR and PYD domains-containing protein 14
, NACHT, leucine rich repeat and PYD containing 14
, RNI-like protein
, germ cell specific leucine-rich repeat NTPase
, germ-cell specific leucine rich repeat NTPase
, NLR family, pyrin domain containing 14
, NACHT, LRR and PYD containing protein 14
, nucleotide-binding oligomerization domain protein 5
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 14