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NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1\; MIM 147678) by Toll-like receptors (see TLR4\; MIM 603030). Additionally we are shipping NLRP2 Proteins (5) and NLRP2 Kits (3) and many more products for this protein.
Showing 10 out of 173 products:
Hamster Polyclonal NLRP2 Primary Antibody for ChIP, ICC - ABIN151077
Goldberg, Stucki, Falck, DAmours, Rahman, Pappin, Bartek, Jackson: MDC1 is required for the intra-S-phase DNA damage checkpoint. in Nature 2003
Show all 149 references for ABIN151077
Human Monoclonal NLRP2 Primary Antibody for ICC, IF - ABIN151633
den Dulk, van Eijk, de Ruijter, Brandsma, Brouwer: The NER protein Rad33 shows functional homology to human Centrin2 and is involved in modification of Rad4. in DNA repair 2008
Show all 17 references for ABIN151633
Human Monoclonal NLRP2 Primary Antibody for ICC, IF - ABIN151641
Suzuki, Yamauchi, Yamashita: ATM-dependent cellular response to DNA double strand breaks plays a pivotal role in the maintenance of the integrity of the genome. in Radiation protection dosimetry 2011
Show all 5 references for ABIN151641
Chicken Monoclonal NLRP2 Primary Antibody for IF, WB - ABIN968688
Carney, Maser, Olivares, Davis, Le Beau, Yates, Hays, Morgan, Petrini: The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. in Cell 1998
Show all 4 references for ABIN968688
Human Polyclonal NLRP2 Primary Antibody for IHC (p), IHC - ABIN438536
Moeller, Yordy, Williams, Giri, Raju, Molkentine, Byers, Heymach, Story, Lee, Sturgis, Weber, Garden, Ang, Schwartz: DNA repair biomarker profiling of head and neck cancer: Ku80 expression predicts locoregional failure and death following radiotherapy. in Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Show all 2 references for ABIN438536
Human Polyclonal NLRP2 Primary Antibody for ChIP, ICC - ABIN253125
Dobbin, Madabhushi, Pan, Chen, Kim, Gao, Ahanonu, Pao, Qiu, Zhao, Tsai: SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons. in Nature neuroscience 2013
Show all 2 references for ABIN253125
Human Polyclonal NLRP2 Primary Antibody for IHC (p), IHC - ABIN438614
Baltanás, Casafont, Lafarga, Weruaga, Alonso, Berciano, Lafarga: Purkinje cell degeneration in pcd mice reveals large scale chromatin reorganization and gene silencing linked to defective DNA repair. in The Journal of biological chemistry 2011
Human Polyclonal NLRP2 Primary Antibody for EIA, WB - ABIN500312
Tschopp, Martinon, Burns: NALPs: a novel protein family involved in inflammation. in Nature reviews. Molecular cell biology 2003
Human Polyclonal NLRP2 Primary Antibody for EIA, WB - ABIN498067
Ji, Shin, Kim, Oh, Min, Choi: Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells. in Infection and immunity 2009
Mouse (Murine) Polyclonal NLRP2 Primary Antibody for IP, WB - ABIN253119
Xie, Kwok, Scully: Role of mammalian Mre11 in classical and alternative nonhomologous end joining. in Nature structural & molecular biology 2009
MRN (Mre11 (show MRE11A Antibodies), Rad50 (show RAD50 Antibodies), and Nbs1) complex, CtIP (show RBBP8 Antibodies), and BRCA1 are required for both the removal of Top2 (show TOP2 Antibodies)-DNA adducts and the subsequent resection of Top2 (show TOP2 Antibodies)-adducted DSB ends.
MRN (MRE11 (show MRE11A Antibodies)-RAD50 (show RAD50 Antibodies)-NBS1) complex has role in ATR (show ATR Antibodies) activation via TOPBP1 (show TOPBP1 Antibodies) recruitment.
Dna2 (show DNA2 Antibodies) co-localizes in foci with RPA (show RPA1 Antibodies) and is found in a complex with replication fork components And-1 and Mcm10 (show MCM10 Antibodies). Dna2 (show DNA2 Antibodies) interacts with the DSB repair and checkpoint proteins Nbs1 and ATM (show ATM Antibodies).
Results indicate a role for the X. laevis Mre11 (show MRE11A Antibodies)/Rad50 (show RAD50 Antibodies)/Nbs1 complex in microhomology-mediated end joining.
Through nuclear magnetic resonance three-dimensional structure determination, data demonstrate that there is a second BRCT domain (BRCT2) in Nbs1.
These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM (show ATM Antibodies) promotes the TopBP1 (show TOPBP1 Antibodies)-dependent activation of ATR (show ATR Antibodies)-ATRIP (show ATRIP Antibodies) in response to double-stranded DNA breaks.
suggests that Mre11 (show MRE11A Antibodies)-Rad50 (show RAD50 Antibodies)-Nbs1 inactivation participates in the down-regulation of damage signaling during checkpoint recovery following double-strand breaks repair.
No disease-causing mutations were identified in NLRP2, NLRP7 (show NLRP7 Antibodies) and KHDC3L (show KHDC3L Antibodies) in cohorts of unexplained infertility and recurrent pregnancy loss.
This study indicates that polymorphisms in SPARC and NLRP2 are related to rheumatoid arthritis susceptibility in a Chinese Han population.
Findings suggest that NLR family pyrin domain containing 2 (NLRP2P) is a processed pseudogene that regulates NF-kappaB (show NFKB1 Antibodies) RelA/p65 (show NFkBP65 Antibodies) activity and thus represents the newest member of the POP (show PREP Antibodies) family, pyrin (show MEFV Antibodies)-only protein 4 (POP4 (show POP4 Antibodies); NLRP4 (show NLRP4 Antibodies)).
The results of this study suggest that the astrocytic NLRP2 inflammasome is an important component of the CNS inflammatory response
There is a significant association of a tag single-nucleotide polymorphism (SNP) of NLRP7 (show NLRP7 Antibodies) (rs26949) with idiopathic recurrent miscarriage
single nucleotide polymorphisms in NALP2 gene is associated with arsenic induced skin lesions, peripheral neuropathy, eye problem and respiratory diseases.
Observations suggest that although NLRP7 (show NLRP7 Antibodies) and C6orf221 (show KHDC3L Antibodies) mutations are related to diploid biparental FRHMs, neither of these genes, nor NLRP2, are related to diploid HMs (show CTSC Antibodies) with biparental contributions to the molar genome.
POP2 (show CNOT8 Antibodies) acts as a regulator of inflammatory signals and exerts its two known functions through distinct modalities employed by its first alpha-helix
Our observations are the first to implicate SPARC (show SPARC Antibodies), SLPI (show SLPI Antibodies), and NLRP2, a component of the innate immune system, in the pathogenesis of axial spondyloarthropathy
functions as a modulator of the activation of NF-kappaB (show NFKB1 Antibodies) and pro-caspase-1 (show CASP1 Antibodies) in macrophages
Nlrp2 is a member of the mammalian maternal effect (show NLRP5 Antibodies) genes and required for early embryonic development in the mouse.
POP2 (show CNOT7 Antibodies) acts as a regulator of inflammatory signals and exerts its two known functions through distinct modalities employed by its first alpha-helix
NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1\; MIM 147678) by Toll-like receptors (see TLR4\; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003
NLR family, pyrin domain containing 2
, NACHT, leucine rich repeat and PYD containing 2
, NACHT, LRR and PYD domains-containing protein 2-like
, Nijmegen breakage syndrome 1
, nijmegen breakage syndrome protein 1 homolog
, NACHT, LRR and PYD containing protein 2
, NACHT, LRR and PYD domains-containing protein 2
, PYRIN domain and NACHT domain-containing protein 1
, PYRIN-containing APAF1-like protein 2
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2
, nucleotide-binding site protein 1