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NLR Family, Pyrin Domain Containing 2 Proteins (NLRP2)

NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1\; MIM 147678) by Toll-like receptors (see TLR4\; MIM 603030). Additionally we are shipping NLRP2 Antibodies (99) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat NLRP2 NLRP2 85482 Q9JIL9
NLRP2 55655 Q9NX02
Mouse NLRP2 NLRP2 232827  
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Top NLRP2 Proteins at antibodies-online.com

Showing 3 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NLRP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for NLR Family, Pyrin Domain Containing 2 (NLRP2) Interaction Partners

Xenopus laevis NLR Family, Pyrin Domain Containing 2 (NLRP2) interaction partners

  1. MRN (Mre11 (show MRE11A Proteins), Rad50 (show RAD50 Proteins), and Nbs1) complex, CtIP (show RBBP8 Proteins), and BRCA1 are required for both the removal of Top2 (show TOP2 Proteins)-DNA adducts and the subsequent resection of Top2 (show TOP2 Proteins)-adducted DSB ends.

  2. MRN (MRE11 (show MRE11A Proteins)-RAD50 (show RAD50 Proteins)-NBS1) complex has role in ATR activation via TOPBP1 (show TOPBP1 Proteins) recruitment.

  3. Dna2 co-localizes in foci with RPA (show RPA1 Proteins) and is found in a complex with replication fork components And-1 and Mcm10 (show MCM10 Proteins). Dna2 interacts with the DSB repair and checkpoint proteins Nbs1 and ATM (show ATM Proteins).

  4. Results indicate a role for the X. laevis Mre11 (show MRE11A Proteins)/Rad50 (show RAD50 Proteins)/Nbs1 complex in microhomology-mediated end joining.

  5. Through nuclear magnetic resonance three-dimensional structure determination, data demonstrate that there is a second BRCT domain (BRCT2) in Nbs1.

  6. These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM (show ATM Proteins) promotes the TopBP1 (show TOPBP1 Proteins)-dependent activation of ATR-ATRIP (show ATRIP Proteins) in response to double-stranded DNA breaks.

  7. suggests that Mre11 (show MRE11A Proteins)-Rad50 (show RAD50 Proteins)-Nbs1 inactivation participates in the down-regulation of damage signaling during checkpoint recovery following double-strand breaks repair.

Human NLR Family, Pyrin Domain Containing 2 (NLRP2) interaction partners

  1. No disease-causing mutations were identified in NLRP2, NLRP7 and KHDC3L in cohorts of unexplained infertility and recurrent pregnancy loss.

  2. This study indicates that polymorphisms in SPARC and NLRP2 are related to rheumatoid arthritis susceptibility in a Chinese Han population.

  3. Findings suggest that NLR family pyrin domain containing 2 (NLRP2P) is a processed pseudogene that regulates NF-kappaB (show NFKB1 Proteins) RelA/p65 (show NFkBP65 Proteins) activity and thus represents the newest member of the POP (show PREP Proteins) family, pyrin (show MEFV Proteins)-only protein 4 (POP4 (show POP4 Proteins); NLRP4).

  4. The results of this study suggest that the astrocytic NLRP2 inflammasome is an important component of the CNS inflammatory response

  5. There is a significant association of a tag single-nucleotide polymorphism (SNP) of NLRP7 (rs26949) with idiopathic recurrent miscarriage

  6. single nucleotide polymorphisms in NALP2 gene is associated with arsenic induced skin lesions, peripheral neuropathy, eye problem and respiratory diseases.

  7. Observations suggest that although NLRP7 and C6orf221 mutations are related to diploid biparental FRHMs, neither of these genes, nor NLRP2, are related to diploid HMs (show CTSC Proteins) with biparental contributions to the molar genome.

  8. POP2 (show CNOT8 Proteins) acts as a regulator of inflammatory signals and exerts its two known functions through distinct modalities employed by its first alpha-helix

  9. Our observations are the first to implicate SPARC (show SPARC Proteins), SLPI (show SLPI Proteins), and NLRP2, a component of the innate immune system, in the pathogenesis of axial spondyloarthropathy

  10. functions as a modulator of the activation of NF-kappaB (show NFKB1 Proteins) and pro-caspase-1 (show CASP1 Proteins) in macrophages

Mouse (Murine) NLR Family, Pyrin Domain Containing 2 (NLRP2) interaction partners

  1. Nlrp2 is a member of the mammalian maternal effect genes and required for early embryonic development in the mouse.

  2. POP2 (show CNOT7 Proteins) acts as a regulator of inflammatory signals and exerts its two known functions through distinct modalities employed by its first alpha-helix

NLRP2 Protein Profile

Protein Summary

NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1\; MIM 147678) by Toll-like receptors (see TLR4\; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003

Gene names and symbols associated with NLRP2

  • NLR family, pyrin domain containing 2 (NLRP2)
  • NLR family, pyrin domain containing 2 (LOC100344125)
  • nibrin (nbn)
  • nibrin (Nbn)
  • NLR family, pyrin domain containing 2 (Nlrp2)
  • CLR19.9 protein
  • E330007A02Rik protein
  • Nalp2 protein
  • nbs protein
  • NBS1 protein
  • NLRP2 protein
  • PAN1 protein
  • PYPAF2 protein

Protein level used designations for NLRP2

NLR family, pyrin domain containing 2 , NACHT, leucine rich repeat and PYD containing 2 , NACHT, LRR and PYD domains-containing protein 2-like , Nijmegen breakage syndrome 1 , nijmegen breakage syndrome protein 1 homolog , NACHT, LRR and PYD containing protein 2 , NACHT, LRR and PYD domains-containing protein 2 , PYRIN domain and NACHT domain-containing protein 1 , PYRIN-containing APAF1-like protein 2 , nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2 , nucleotide-binding site protein 1

GENE ID SPECIES
484304 Canis lupus familiaris
697844 Macaca mulatta
100055187 Equus caballus
100301026 Bos taurus
100344125 Oryctolagus cuniculus
100387349 Callithrix jacchus
100516741 Sus scrofa
403373 Xenopus laevis
85482 Rattus norvegicus
55655 Homo sapiens
469011 Pan troglodytes
232827 Mus musculus
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