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The protein encoded by NLRP5 belongs to the NALP protein family. Additionally we are shipping and many more products for this protein.
Showing 10 out of 13 products:
Human Polyclonal NLRP5 Primary Antibody for EIA, WB - ABIN783707
Tschopp, Martinon, Burns: NALPs: a novel protein family involved in inflammation. in Nature reviews. Molecular cell biology 2003
Show all 2 references for ABIN783707
NLRP5 mutation is associated with multilocus imprinting disorders and reproductive wastage.
characterization of the MATER gene and its protein; this provides a basis for investigating their clinical implications in autoimmune premature ovarian failure and infertility in women
NALP5 appears to be a tissue-specific autoantigen involved in hypoparathyroidism in patients with APS-1. Autoantibodies against NALP5 appear to be highly specific and may be diagnostic for this prominent component of APS-1
MATER protein interacts with tPKCepsilon in cumulus cells under physiological conditions.
MATER is part of the subcortical maternal complex (SCMC). SCMC is required for formation of the cytoplasmic F-actin meshwork that controls the central position of the spindle and ensures symmetric division.
MATER is required for endoplasmic reticulum distribution and Ca2 (show CA2 Antibodies)+ homeostasis in oocytes, likely due to defects in lattice-mediated ER positioning and/or redistribution.
It was concluded that lack of Nlrp5 in oocytes triggers premature activation of the mitochondrial pool, causing mitochondrial damage that cannot be rescued by inactivation of Bax (show BAX Antibodies).
Transgenic expression of MATER induces antigen-specific tolerance with a significant reduction in ovarian autoimmunity.
MATER co-localizes with PADI6 at the oocyte cytoplasmic lattices.
Mater gene transcription and protein translation are active during oogenesis, but appear inactive during early embryogenesis
MATER and three similar genes are localized to mouse chromosome 7
The plasticity of the FILIA-MATER complex localization may reflect the regulative nature of preimplantation mouse development.
Results describe a subcortical maternal complex, containing Mater, Floped, TLE6, and Filia, that is essential for preimplantation mouse embryogenesis.
The highest Mater mRNA levels were detected in oocytes in the pre-antral follicle stage.
Assignment to a QTL region for reproductive traits and preferential expression of NALP9 (show NLRP9 Antibodies), NALP8, and NALP5 in oocyte, germinal lineage, and gonad cells may suggest their functional relevance to reproduction and possible contribution to phenotypic variation
In situ hybridization confirmed oocyte-restricted expression of MATER within the ovary, as early as preantral follicle stages.
expression patterns are consistent with bovine MATER protein being an oocyte specific maternal effect factor (show ZAR1 Antibodies) as in mouse
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis.
NACHT, LRR and PYD domains-containing protein 5
, NACHT, leucine rich repeat and PYD containing 5
, mater protein homolog
, maternal antigen that embryos require
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 5
, maternal effect
, ooplasm-specific protein 1