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NLRP7 encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. Additionally we are shipping and many more products for this protein.
Showing 10 out of 41 products:
Human Polyclonal NLRP7 Primary Antibody for IHC (p), IHC (wm) - ABIN4340138
Mahadevan, Wen, Wan, Peng, Otta, Liu, Iacovino, Mahen, Kyba, Sadikovic, Van den Veyver: NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 and alters CpG methylation. in Human molecular genetics 2014
Show all 4 references for ABIN4340138
Human Polyclonal NLRP7 Primary Antibody for EIA, WB - ABIN783711
Tschopp, Martinon, Burns: NALPs: a novel protein family involved in inflammation. in Nature reviews. Molecular cell biology 2003
the NLRP7 inflammasome contributes to IL-1beta (show IL1B Antibodies) secretion and induction of pyroptosis in response to M. bovis infection in THP-1 (show GLI2 Antibodies) macrophages.
maternal-effect (show NLRP5 Antibodies) mutations of NLRP7 are associated with the most severe form of multi-locus imprinting defects in humans
No disease-causing mutations were identified in NLRP2 (show NLRP2 Antibodies), NLRP7 and KHDC3L (show KHDC3L Antibodies) in cohorts of unexplained infertility and recurrent pregnancy loss.
NLRP7 and KHDC3L (show KHDC3L Antibodies) localize to the cytoskeleton and are predominant at the cortical region in growing oocytes.
NLRP7 is involved in Hydatidiform Molar Pregnancy (HYDM1) and interacts with the transcriptional repressor ZBTB16 (show ZBTB16 Antibodies)
These results provide novel insights into the mechanism of NLRP7 inflammasome assembly.
NLRP7, depending on the severity of its mutations, regulates the imprinted expression of p57KIP2 (show CDKN1C Antibodies) and consequently the balance between tissue differentiation and proliferation during early human development.
NLRP7 thus appears to function in chromatin reprogramming and DNA methylation (show HELLS Antibodies) in the germline or early embryonic development.NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 (show YY1 Antibodies) and alters CpG methylation.
The absence of mutations in women with Androgenetic complete hydatidiform moles supports a role for NLRP7 or KHDC3L (show KHDC3L Antibodies) in Biparental hydatidiform moles only.
A statistically non-significant tendency of non-synonymous variants in NLRP7 more frequent in women with familial hydatidiform mole and in women with female family members with hydatidiform mole or non-mole miscarriage.
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.
NACHT, LRR and PYD containing protein 7
, NACHT, LRR and PYD domains-containing protein 7
, NACHT, leucine rich repeat and PYD containing 7
, PYRIN-containing Apaf1-like protein 3
, nucleotide-binding oligomerization domain protein 12
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7