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NLRX1 encodes a member of the NLR family. Additionally we are shipping NLRX1 Antibodies (57) and and many more products for this protein.
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The data suggests that NLRX1 plays a positive role in Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication by suppressing the IFNbeta response during the process of KSHV reactivation, which might serve as a potential target for restricting KSHV replication and transmission.
we identify a novel signaling hub centering on the NLRX1 TUFM (show Tufm ELISA Kits) protein complex, promoting autophagic flux. Defects in the expression of either NLRX1 or TUFM (show Tufm ELISA Kits) result in compromised autophagy when treated with EGFR (show EGFR ELISA Kits) inhibitors.These findings expand our understanding of the components involved in head and neck squamous cell carcinoma autophagy machinery that responds to EGFR (show EGFR ELISA Kits) inhibitors.
findings suggest that NLRX1 may function as a cardiac-protective molecule in myocardial ischemic injury by repressing inflammation and apoptosis
NLRX1, NLRP12 and NLRC3 (show NLRC3 ELISA Kits) negatively modulate the host immune response following virus exposure. (Review)
NLRX1 acts as a potential tumor suppressor by regulating the TNF-alpha (show TNF ELISA Kits) induced cell death and metabolism.
These data support a model in which CS-dependent NLRX1 inhibition facilitates MAVS (show MAVS ELISA Kits)/RHL (show DDX46 ELISA Kits) activation and subsequent inflammation, remodeling, protease, cell death, and inflammasome responses.
Together, these results suggest a novel mechanism for rhinovirus-induced epithelial barrier disruption involving NLRX-1 and mitochondrial reactive oxygen species generation.
NLRX1 and TUFM (show Tufm ELISA Kits) work in concert to reduce cytokine response and augment autophagy.
Results showed that missense mutations in transmembrane protein 2 p.Ser1254Asn, interferon alpha 2 p.Ala120Thr, its regulator NLR family member X1 p.Arg707Cys, and complement component 2 p.Glu318Asp were associated with chronic hepatitis B.
Post-transcriptional inhibition of luciferase reporter assays by the Nod-like receptor proteins NLRX1 and NLRC3 (show NLRC3 ELISA Kits).
this in vitro studies show that NLRX1-deficient T cells have a greater ability to differentiate into an inflammatory phenotype and possess greater proliferation rates
NLRX1 sequesters the DNA-sensing adaptor STING from interaction with TBK1 (show TBK1 ELISA Kits), which is a requisite for IFN-1 induction in response to viral DNA.
NLRX1 diminishes Tumor Necrosis Factor-alpha (show TNF ELISA Kits)-induced activation of both Akt (show AKT1 ELISA Kits)- and NF-kappaB (show NFKB1 ELISA Kits)-dependent pathways. Since Akt (show AKT1 ELISA Kits) was shown to be essential for Tumor Necrosis Factor-alpha (show TNF ELISA Kits)-mediated activation of NF-kappaB (show NFKB1 ELISA Kits) it is likely that the primary effect of NLRX1 is at the level of C-Akt (show AKT1 ELISA Kits) proein signaling.
NLRX1 attenuated Apc (show APC ELISA Kits)(min/+) colon tumorigenesis, cellular proliferation, NF-KappaB (show NFKB1 ELISA Kits), mitogen-activated protein kinase (show MAPK1 ELISA Kits), signal transducer and activator of transcription 3 (show STAT3 ELISA Kits) activation, and interleukin 6 (show IL6 ELISA Kits) levels.
NLRX1 may relate to hair cell maturity, hearing formation and maintenance, and promote hair cell apoptosis through JNK (show MAPK8 ELISA Kits) pathway
The regulatory role of NLRX1 in mechanisms of host tolerance employed by macrophages to respond to Helicobacter pylori infection.NLRX1 modulates innate immune responses to Helicobacter pylori infection.
Nlrx1 may play an important role in neurodegenerative diseases, where necrosis is a prominent factor.
The unique capacity of NLRX1 to regulate the cellular sensitivity toward intrinsic versus extrinsic apoptotic signals suggests a critical role for this protein in numerous physiological processes and pathological conditions.
NLRX1 enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein, as well as preventing mitochondrial-induced apoptosis
This gene encodes a member of the NLR family. Alternative splicing has been observed at this gene locus and two transcript variants, encoding distinct isoforms, have been identified.
NLR family member X1
, NLR family, X1
, NOD-like receptor X1
, caterpiller protein 11.3
, nucleotide-binding oligomerization domain protein 26
, nucleotide-binding oligomerization domain protein 5
, nucleotide-binding oligomerization domain protein 9
, nucleotide-binding oligomerization domain, leucine rich repeat containing X1
, nucleotide-binding domain and leucine-rich repeat containing