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This homeobox gene encodes a transcription factor that is thought to play a role in oogenesis. Additionally we are shipping NOBOX Antibodies (31) and many more products for this protein.
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Screening of NOBOX gene indicted three missense mutations (p.Arg117Trp; p.Gly91Trp and p.Pro619Leu) in eight patients with primary ovarian insufficiency.
High prevalence of the association between the NOBOX rare variants and Primary ovarian insufficiency.
both NOBOX and FOXL2 (show FOXL2 Proteins) are expressed in human follicle granulosa cells and their interaction plays an inhibitory role in the transcriptional response of these promoters.
The very high 6.2% prevalence of these new mutations in POI patients suggest considering NOBOX as the first autosomal candidate gene involved in this syndrome.
Mutations of the homeobox (show Lbx1 Proteins) region of the NOBOX gene are uncommon in Japanese patients with premature ovarian failure.
NOBOX expression within adult human tissues is limited to the testis, pancreas and oocyte specific in ovary.
These findings demonstrate that NOBOX mutations can cause premature ovarian failure.
Mutations in the homeobox (show Lbx1 Proteins) domain of NOBOX are not common explanations for POF (show POF1B Proteins) in Chinese women.
The NOBOX protein is expressed throughout oocyte growth in the nucleus of ovarian Non Surrounded Nucleolus and in MII(Non Surrounded Nucleolus) oocytes; beginning with Surrounded Nucleolus oocytes of 61-70 microm, it becomes almost undetectable.
These results indicate that premature ovarian failure syndrome in Nobox deficient mice results from the faulty signaling between somatic and germ line components during embryonic development.
identified one Nobox DNA-binding element within the Pad6 promoter. findings indicate that Nobox is a critical regulator that orchestrates oocyte-specific genes such as Pad6 during folliculogenesis.
Nobox is critical for specifying an oocyte-restricted gene expression pattern essential for postnatal follicle development
NOBOX directly regulates the transcription of Pou5f1 (show POU5F1 Proteins) and Gdf9 (show GDF9 Proteins) in oocytes during early folliculogenesis
findings indicate that Nobox is likely an activator of oocyte-specific gene expression
RT-PCR data shows an increase in oogenesis specific gene transcripts (Nobox, Oct4 (show POU5F1 Proteins), Bmp15 (show BMP15 Proteins), Gdf9 (show GDF9 Proteins), Oogenesin1 and Oogenesin2) between the primordial until the preantral stages, with the exception of the Oogenesin1 transcripts under gonadotropin-induction.
The expression levels of this gene in heart, kidney and oocytes are higher than that in other tissues, which suggested that the NOBOX protein might play an important role in those tissues.
Results demonstrate that miR (show MYLIP Proteins)-196a is a bona fide negative regulator of NOBOX during bovine early embryogenesis.
This study demonstrates that NOBOX is an essential maternal-derived transcription factor during bovine early embryogenesis, which functions in regulation of embryonic genome activation, pluripotency gene expression, and blastocyst cell allocation.
This homeobox gene encodes a transcription factor that is thought to play a role in oogenesis. In mice, it is essential for folliculogenesis and regulation of oocyte-specific genes. Defects in this gene result in premature ovarian failure type 5.
NOBOX oogenesis homeobox
, homeobox protein NOBOX-like
, homeobox protein NOBOX
, newborn ovary homeobox-encoding
, OG2 homeobox
, homeodomain-containing protein OG-2
, newborn ovary homeobox protein
, oocyte-specific homeobox protein