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anti-NOP2/Sun Domain Family, Member 2 (NSUN2) Antibodies

NSUN2 encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Additionally we are shipping NSUN2 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NSUN2 28114 Q1HFZ0
NSUN2 54888 Q08J23
NSUN2 361191  
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Top anti-NSUN2 Antibodies at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-NSUN2 Antibody Titration: 0.2-1 ug/mlPositive Control: Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB NSUN2 Antibody (Center) western blot analysis in mouse spleen tissue lysates (35µg/lane).This demonstrates the NSUN2 antibody detected the NSUN2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB NSUN2 Antibody (Center) (ABIN654767) western blot analysis in mouse spleen tissue lysates (35 µg/lane). This demonstrates the NSUN2 antibody detected the NSUN2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Mouse Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 5 to 6 Days
$485.80
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 14 Days
$527.15
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB NSUN2 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details

NSUN2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)


Human ,


, , , , ,
Rat (Rattus)


Top referenced anti-NSUN2 Antibodies

  1. Mouse (Murine) Polyclonal NSUN2 Primary Antibody for IHC, ELISA - ABIN809116 : Hussain, Tuorto, Menon, Blanco, Cox, Flores, Watt, Kudo, Lyko, Frye: The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation. in Molecular and cellular biology 2013 (PubMed)
    Show all 3 references for ABIN809116

  2. Human Polyclonal NSUN2 Primary Antibody for WB - ABIN654767 : Hussain, Benavente, Nascimento, Dragoni, Kurowski, Gillich, Humphreys, Frye: The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability. in The Journal of cell biology 2009 (PubMed)
    Show all 2 references for ABIN654767

  3. Human Polyclonal NSUN2 Primary Antibody for EIA, WB - ABIN953759 : Frye, Dragoni, Chin, Spiteri, Kurowski, Provenzano, Green, Ellis, Grimmer, Teschendorff, Zouboulis, Caldas, Watt: Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer. in Cancer letters 2010 (PubMed)

  4. Chicken Polyclonal NSUN2 Primary Antibody for WB - ABIN2783512 : Sakita-Suto, Kanda, Suzuki, Sato, Takata, Tatsuka: Aurora-B regulates RNA methyltransferase NSUN2. in Molecular biology of the cell 2007 (PubMed)

More Antibodies against NSUN2 Interaction Partners

Mouse (Murine) NOP2/Sun Domain Family, Member 2 (NSUN2) interaction partners

  1. study identified NSun2 as a novel component of the chromatoid body and show that NSun2 is essential for germ cell differentiation in the testis

  2. Steady-state levels of unmethylated tRNAs were substantially reduced, and loss of Dnmt2 (show TRDMT1 Antibodies) and NSun2 was further associated with reduced rates of overall protein synthesis.

  3. NSUN2 localizes to the nucleolus of Purkinje cells in the cerebellum. Mutation to arginine at residue 679 causes NSUN2 to fail to localize within the nucleolus.

  4. we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin

  5. Misu is a novel downstream Myc (show MYC Antibodies) target that methylates RNA polymerase III transcripts. Misu mediates Myc (show MYC Antibodies)-induced cell proliferation and growth and is a potential target for cancer therapies.

  6. These results suggest a novel mechanism by which c-Myc promotes proliferation by stabilizing the mitotic spindle in fast-dividing cells via Misu and NuSAP.

Human NOP2/Sun Domain Family, Member 2 (NSUN2) interaction partners

  1. These findings indicate that NSun2-mediated mRNA methylation regulates p27 (show PAK2 Antibodies) and CDK1 (show CDK1 Antibodies) levels during replicative senescence.

  2. A novel homozygous variant c.1020delA in NSUN2 gene segregated in an autosomal recessive mode in the family of a child with intellectual disability. It causes a frameshift and premature stop codon, decreasing mRNA levels.

  3. By methylating the CDK1 (show CDK1 Antibodies) mRNA at the 3'UTR (show UTS2R Antibodies), NSun2 enhances the translation of CDK1 (show CDK1 Antibodies), thereby influencing entry into and the progression of the cell division cycle.

  4. tRNA modifying enzymes, NSUN2 and METTL1 (show METTL1 Antibodies), determine sensitivity to 5-fluorouracil in HeLa cells

  5. Report frequencies of short tandem repeat markers linked to TUSC3 (MRT7 (show TUSC3 Antibodies)) or NSUN2 (MRT5) genes used for homozygosity mapping of recessive intellectual disability.

  6. Results show that NSun2 methylates primary (pri-miR (show MLXIP Antibodies)-125b), precursor (pre-miR (show MLXIP Antibodies)-125b), and mature microRNA 125b (miR (show MLXIP Antibodies)-125b) in vitro and in vivo.

  7. In conclusion, failure in NSun2-mediated tRNA methylation contributes to human diseases via stress-induced RNA cleavage.

  8. Impaired processing of vault ncRNA may contribute to the etiology of NSun2-deficiency human disorders.

  9. Enrolled a multiplex consanguineous family from the United Arab Emirates with many key clinical features of Dubowitz syndrome. Identified a homozygous splice mutation in the NSUN2 gene, encoding a conserved RNA methyltransferase.

  10. findings show that NSun2, a transfer RNA methyltransferase, inhibits the turnover of p16(INK4 (show CDKN2A Antibodies)) mRNA; conclude that NSun2-mediated methylation of the p16 (show CDKN2A Antibodies) 3'UTR (show UTS2R Antibodies) is a novel mechanism to stabilize p16 (show CDKN2A Antibodies) mRNA

NSUN2 Antigen Profile

Protein Summary

This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene names and symbols associated with NSUN2

  • NOL1/NOP2/Sun domain family member 2 (Nsun2) antibody
  • NOP2/Sun RNA methyltransferase family, member 2 (NSUN2) antibody
  • NOP2/Sun RNA methyltransferase family, member 2 (Nsun2) antibody
  • NOP2/Sun RNA methyltransferase family, member 2 (nsun2) antibody
  • D13Wsu123e antibody
  • MISU antibody
  • MRT5 antibody
  • RGD1311954 antibody
  • SAKI antibody
  • TRM4 antibody

Protein level used designations for NSUN2

Myc-induced SUN domain containing protein , NOL1/NOP2/Sun domain family 2 , myc-induced SUN domain-containing protein , tRNA (cytosine(34)-C(5))-methyltransferase , tRNA (cytosine-5-)-methyltransferase NSUN2 , NOL1/NOP2/Sun domain family, member 2 , NOP2/Sun domain family, member 2 , 5-methycytoisine methyltransferase , Myc-induced SUN-domain-containing protein , NOL1/NOP2/Sun domain family member 2 , hTrm4 , substrate of AIM1/Aurora kinase B , tRNA methyltransferase 4 homolog

GENE ID SPECIES
28114 Mus musculus
420938 Gallus gallus
54888 Homo sapiens
516044 Bos taurus
361191 Rattus norvegicus
414460 Xenopus laevis
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