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NOP2/Sun Domain Family, Member 2 Proteins (NSUN2)

NSUN2 encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Additionally we are shipping NSUN2 Antibodies (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NSUN2 28114 Q1HFZ0
NSUN2 54888 Q08J23
Rat NSUN2 NSUN2 361191  
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Top NSUN2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NSUN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for NOP2/Sun Domain Family, Member 2 (NSUN2) Interaction Partners

Mouse (Murine) NOP2/Sun Domain Family, Member 2 (NSUN2) interaction partners

  1. study identified NSun2 as a novel component of the chromatoid body and show that NSun2 is essential for germ cell differentiation in the testis

  2. Steady-state levels of unmethylated tRNAs were substantially reduced, and loss of Dnmt2 (show TRDMT1 Proteins) and NSun2 was further associated with reduced rates of overall protein synthesis.

  3. NSUN2 localizes to the nucleolus of Purkinje cells in the cerebellum. Mutation to arginine at residue 679 causes NSUN2 to fail to localize within the nucleolus.

  4. we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin

  5. Misu is a novel downstream Myc (show MYC Proteins) target that methylates RNA polymerase III transcripts. Misu mediates Myc (show MYC Proteins)-induced cell proliferation and growth and is a potential target for cancer therapies.

  6. These results suggest a novel mechanism by which c-Myc promotes proliferation by stabilizing the mitotic spindle in fast-dividing cells via Misu and NuSAP.

Human NOP2/Sun Domain Family, Member 2 (NSUN2) interaction partners

  1. These findings indicate that NSun2-mediated mRNA methylation regulates p27 (show PAK2 Proteins) and CDK1 (show CDK1 Proteins) levels during replicative senescence.

  2. A novel homozygous variant c.1020delA in NSUN2 gene segregated in an autosomal recessive mode in the family of a child with intellectual disability. It causes a frameshift and premature stop codon, decreasing mRNA levels.

  3. By methylating the CDK1 (show CDK1 Proteins) mRNA at the 3'UTR, NSun2 enhances the translation of CDK1 (show CDK1 Proteins), thereby influencing entry into and the progression of the cell division cycle.

  4. tRNA modifying enzymes, NSUN2 and METTL1 (show METTL1 Proteins), determine sensitivity to 5-fluorouracil in HeLa cells

  5. Report frequencies of short tandem repeat markers linked to TUSC3 (MRT7 (show TUSC3 Proteins)) or NSUN2 (MRT5) genes used for homozygosity mapping of recessive intellectual disability.

  6. Results show that NSun2 methylates primary (pri-miR (show MLXIP Proteins)-125b), precursor (pre-miR (show MLXIP Proteins)-125b), and mature microRNA 125b (miR (show MLXIP Proteins)-125b) in vitro and in vivo.

  7. In conclusion, failure in NSun2-mediated tRNA methylation contributes to human diseases via stress-induced RNA cleavage.

  8. Impaired processing of vault ncRNA may contribute to the etiology of NSun2-deficiency human disorders.

  9. Enrolled a multiplex consanguineous family from the United Arab Emirates with many key clinical features of Dubowitz syndrome. Identified a homozygous splice mutation in the NSUN2 gene, encoding a conserved RNA methyltransferase.

  10. findings show that NSun2, a transfer RNA methyltransferase, inhibits the turnover of p16(INK4) mRNA; conclude that NSun2-mediated methylation of the p16 3'UTR is a novel mechanism to stabilize p16 mRNA

NSUN2 Protein Profile

Protein Summary

This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene names and symbols associated with NSUN2

  • NOL1/NOP2/Sun domain family member 2 (Nsun2)
  • NOP2/Sun RNA methyltransferase family, member 2 (NSUN2)
  • NOP2/Sun RNA methyltransferase family, member 2 (Nsun2)
  • NOP2/Sun RNA methyltransferase family, member 2 (nsun2)
  • D13Wsu123e protein
  • MISU protein
  • MRT5 protein
  • RGD1311954 protein
  • SAKI protein
  • TRM4 protein

Protein level used designations for NSUN2

Myc-induced SUN domain containing protein , NOL1/NOP2/Sun domain family 2 , myc-induced SUN domain-containing protein , tRNA (cytosine(34)-C(5))-methyltransferase , tRNA (cytosine-5-)-methyltransferase NSUN2 , NOL1/NOP2/Sun domain family, member 2 , NOP2/Sun domain family, member 2 , 5-methycytoisine methyltransferase , Myc-induced SUN-domain-containing protein , NOL1/NOP2/Sun domain family member 2 , hTrm4 , substrate of AIM1/Aurora kinase B , tRNA methyltransferase 4 homolog

GENE ID SPECIES
28114 Mus musculus
420938 Gallus gallus
54888 Homo sapiens
516044 Bos taurus
361191 Rattus norvegicus
414460 Xenopus laevis
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