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Promotes loss of intracellular domain (ICD) of Notch1 in embryos. Additionally we are shipping NRARP Antibodies (42) and and many more products for this protein.
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Downregulation of NRARP expression exerts significant antitumor activities against cell growth and invasion of thyroid cancer, that suggests a potential role of NRARP in thyroid cancer targeted therapy.
NRARP may stimulate cell proliferation in human breast cancer.
The transcription and expression patterns of Notch (show NOTCH1 Proteins) pathway components (Notch 1 (show NOTCH1 Proteins)-3, Delta1 and 4, Jagged1 (show JAG1 Proteins)) and effectors (Hes1, Hes2 (show HES2 Proteins), Hes5 (show HES5 Proteins) and Nrarp) were evaluated in the mouse testis
Nrarp is essential for forming the proper number and morphology of axial skeleton components
Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate.
Different effects of Nrarp overexpression suggest that alternate Notch (show NOTCH1 Proteins) signaling pathways mediate T- versus B-cell lineage commitment and thymocyte maturation.
Results show that the Notch-regulated ankyrin repeat protein (Nrarp) acts as a molecular link between Notch (show NOTCH1 Proteins)- and Lef1 (show LEF1 Proteins)-dependent Wnt (show WNT2 Proteins) signaling in endothelial cells to control stability of new vessel connections in mouse and zebrafish.
please add ref (show THOC4 Proteins) to Xenopus: 2002 Mechanisms of Development 110, 113-124. Where they call it "Xnap"
Promotes loss of intracellular domain (ICD) of Notch1 in embryos. By down-regulating ICD levels, could function as a negative feedback regulator of Notch signaling that attenuates ICD-mediated transcription.
notch-regulated ankyrin repeat-containing protein