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anti-NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) Antibodies

The protein encoded by NPC1L1 is a multi-pass membrane protein. Additionally we are shipping NPC1L1 Proteins (10) and NPC1L1 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NPC1L1 237636  
NPC1L1 432367 Q6T3U3
NPC1L1 29881 Q9UHC9
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Top anti-NPC1L1 Antibodies at antibodies-online.com

Showing 10 out of 44 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB NPC1L1 Antibody (N-term) (ABIN1881583) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the NPC1L1 antibody detected the NPC1L1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Rat Rabbit Un-conjugated IHC (p), WB Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$405.17
Details
Mouse Goat Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$419.83
Details
Mouse Goat Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$419.83
Details
Mouse Goat Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Mouse Goat Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit FITC ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Mouse Goat Un-conjugated ELISA   100 μg Log in to see 4 to 5 Days
$221.76
Details
Mouse Goat Un-conjugated ELISA   100 μg Log in to see 4 to 5 Days
$221.76
Details

NPC1L1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,


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Rat (Rattus) ,
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Human


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Top referenced anti-NPC1L1 Antibodies

  1. Human Polyclonal NPC1L1 Primary Antibody for WB - ABIN1881583 : Teslovich, Musunuru, Smith, Edmondson, Stylianou, Koseki, Pirruccello, Ripatti, Chasman, Willer, Johansen, Fouchier, Isaacs, Peloso, Barbalic, Ricketts, Bis, Aulchenko, Thorleifsson, Feitosa et al.: Biological, clinical and population relevance of 95 loci for blood lipids. ... in Nature 2010 (PubMed)
    Show all 5 references for ABIN1881583

More Antibodies against NPC1L1 Interaction Partners

Pig (Porcine) NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) interaction partners

  1. We therefore propose that cholesterol is absorbed by NPC1L1 acting as a membrane transporter and that NPC1L1 is internalized to an endosomal compartment to reduce the absorption of cholesterol.

Mouse (Murine) NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) interaction partners

  1. NPC1L1 knockout protects against colitis-associated tumorigenesis.

  2. demonstrate that Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter, plays a central role in intestinal VK uptake and modulates the anticoagulant effect of warfarin. In

  3. NPC1L1 may suppress gluconeogenesis by inhibition of FoxO1 (show FOXO1 Antibodies) pathways.

  4. DNA methylation (show HELLS Antibodies) in the promoter region of the NPC1L1 gene appears to be a major mechanism underlying differential expression of NPC1L1 along the length of the gastrointestinal tract.

  5. cholesterol and tocopherol uptakes share common pathways in cell culture models, but display different in vivo absorption patterns associated with distinct contributions of SR-BI (show SCARB1 Antibodies) and NPC1L1

  6. The clathrin adaptor Numb (show NUMB Antibodies) regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1.

  7. Glucose appears to directly modulate NPC1L1 expression via transcriptional mechanisms and the involvement of phosphatase-dependent pathways.

  8. the mechanism of cholesterol sensing by NPC1L1 and proposes a mechanism for selective cholesterol absorption

  9. Cdc42 (show CDC42 Antibodies) controls the cholesterol-regulated transport and localization of NPC1L1, and plays a role in cholesterol absorption.

  10. These findings demonstrated a direct role of hepatic NPC1L1 in regulating biliary cholesterol excretion and hepatic/blood cholesterol levels, and unequivocally established hepatic NPC1L1 as a target of ezetimibe.

Human NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) interaction partners

  1. Study suggests that the G allele of the NPC1L1 polymorphism g1679C>G may be a positive marker of gallstone formation risk.

  2. To study whether human NPC1L1 gene is regulated transcriptionally by LRH-1 (show NR5A2 Antibodies), we have analyzed evolutionary conserved regions (ECRs) in HepG2 cells.

  3. No significant association between investigated NPC1L1 variants and risk of coronary atherosclerosis could be observed.

  4. Results show that genetic variation in NPC1L1 is associated with a reduction in risk of IVD (show IVD Antibodies), with a corresponding reduction in LDL cholesterol, but with a concomitant increased risk of gallstone disease

  5. The frequencies of NPC1L1 polymorphisms in Chinese Hans are comparable to Japanese population but totally different from Caucasians, African-Americans and Hispanic individuals

  6. demonstrate that Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter, plays a central role in intestinal VK uptake and modulates the anticoagulant effect of warfarin. In

  7. Lipid-lowering response to ezetimibe is not impacted by the NPC1L1 polymorphisms studied in Chilean hypercholesterolemic subjects.

  8. NPC1L1-mediated cholesterol absorption is a major determinant of blood levels of apolipoprotein B (show APOB Antibodies)-containing atherogenic lipoproteins

  9. The effect of lower LDL-C on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR (show HMGCR Antibodies), or both is approximately the same per unit lower LDL-C and log-linearly proportional to the absolute exposure to lower LDL-C.

  10. NPC1L1 polymorphism is associated with sitosterolaemia.

NPC1L1 Antigen Profile

Protein Summary

The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NPC1L1

  • NPC1 (Niemann-Pick disease, type C1, gene)-like 1 (NPC1L1) antibody
  • NPC1-like 1 (NPC1L1) antibody
  • NPC1 (Niemann-Pick disease, type C1, gene)-like 1 (npc1l1) antibody
  • NPC1-like 1 (Npc1l1) antibody
  • 9130221N23Rik antibody
  • Gm243 antibody
  • NPC1L1 antibody
  • NPC11L1 antibody

Protein level used designations for NPC1L1

NPC1-like 1 , NPC1 (Niemann-Pick disease, type C1, gene)-like 1 , Niemann-Pick C1-like protein 1 , Niemann-Pick C1-like 1 protein , Niemann-Pick C1-like protein 1-like , Niemann-Pick disease, type C1 , Niemann-Pick disease, type C1-like 1

GENE ID SPECIES
463381 Pan troglodytes
539550 Bos taurus
610398 Canis lupus familiaris
699235 Macaca mulatta
100009042 Oryctolagus cuniculus
100030165 Monodelphis domestica
100458187 Pongo abelii
100478497 Ailuropoda melanoleuca
100487339 Xenopus (Silurana) tropicalis
100515982 Sus scrofa
100590536 Nomascus leucogenys
100616532 Danio rerio
237636 Mus musculus
432367 Rattus norvegicus
29881 Homo sapiens
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