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NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) ELISA Kits

The protein encoded by NPC1L1 is a multi-pass membrane protein. Additionally we are shipping NPC1L1 Antibodies (44) and NPC1L1 Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
NPC1L1 237636  
Anti-Rat NPC1L1 NPC1L1 432367 Q6T3U3
Anti-Human NPC1L1 NPC1L1 29881 Q9UHC9
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Top NPC1L1 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Mouse 3.9 pg/ml 15.6-1000 pg/mL 96 Tests Log in to see 11 to 13 Days
$910.56
Details

More ELISA Kits for NPC1L1 Interaction Partners

Pig (Porcine) NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) interaction partners

  1. We therefore propose that cholesterol is absorbed by NPC1L1 acting as a membrane transporter and that NPC1L1 is internalized to an endosomal compartment to reduce the absorption of cholesterol.

Mouse (Murine) NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) interaction partners

  1. NPC1L1 knockout protects against colitis-associated tumorigenesis.

  2. demonstrate that Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter, plays a central role in intestinal VK uptake and modulates the anticoagulant effect of warfarin. In

  3. NPC1L1 may suppress gluconeogenesis by inhibition of FoxO1 (show FOXO1 ELISA Kits) pathways.

  4. DNA methylation (show HELLS ELISA Kits) in the promoter region of the NPC1L1 gene appears to be a major mechanism underlying differential expression of NPC1L1 along the length of the gastrointestinal tract.

  5. cholesterol and tocopherol uptakes share common pathways in cell culture models, but display different in vivo absorption patterns associated with distinct contributions of SR-BI (show SCARB1 ELISA Kits) and NPC1L1

  6. The clathrin adaptor Numb (show NUMB ELISA Kits) regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1.

  7. Glucose appears to directly modulate NPC1L1 expression via transcriptional mechanisms and the involvement of phosphatase-dependent pathways.

  8. the mechanism of cholesterol sensing by NPC1L1 and proposes a mechanism for selective cholesterol absorption

  9. Cdc42 (show CDC42 ELISA Kits) controls the cholesterol-regulated transport and localization of NPC1L1, and plays a role in cholesterol absorption.

  10. These findings demonstrated a direct role of hepatic NPC1L1 in regulating biliary cholesterol excretion and hepatic/blood cholesterol levels, and unequivocally established hepatic NPC1L1 as a target of ezetimibe.

Human NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) interaction partners

  1. Study suggests that the G allele of the NPC1L1 polymorphism g1679C>G may be a positive marker of gallstone formation risk.

  2. To study whether human NPC1L1 gene is regulated transcriptionally by LRH-1 (show NR5A2 ELISA Kits), we have analyzed evolutionary conserved regions (ECRs) in HepG2 cells.

  3. No significant association between investigated NPC1L1 variants and risk of coronary atherosclerosis could be observed.

  4. Results show that genetic variation in NPC1L1 is associated with a reduction in risk of IVD (show IVD ELISA Kits), with a corresponding reduction in LDL cholesterol, but with a concomitant increased risk of gallstone disease

  5. The frequencies of NPC1L1 polymorphisms in Chinese Hans are comparable to Japanese population but totally different from Caucasians, African-Americans and Hispanic individuals

  6. demonstrate that Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter, plays a central role in intestinal VK uptake and modulates the anticoagulant effect of warfarin. In

  7. Lipid-lowering response to ezetimibe is not impacted by the NPC1L1 polymorphisms studied in Chilean hypercholesterolemic subjects.

  8. NPC1L1-mediated cholesterol absorption is a major determinant of blood levels of apolipoprotein B (show APOB ELISA Kits)-containing atherogenic lipoproteins

  9. The effect of lower LDL-C on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR (show HMGCR ELISA Kits), or both is approximately the same per unit lower LDL-C and log-linearly proportional to the absolute exposure to lower LDL-C.

  10. NPC1L1 polymorphism is associated with sitosterolaemia.

NPC1L1 Antigen Profile

Antigen Summary

The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NPC1L1

  • NPC1 (Niemann-Pick disease, type C1, gene)-like 1 (NPC1L1) antibody
  • NPC1-like 1 (NPC1L1) antibody
  • NPC1 (Niemann-Pick disease, type C1, gene)-like 1 (npc1l1) antibody
  • NPC1-like 1 (Npc1l1) antibody
  • 9130221N23Rik antibody
  • Gm243 antibody
  • NPC1L1 antibody
  • NPC11L1 antibody

Protein level used designations for NPC1L1

NPC1-like 1 , NPC1 (Niemann-Pick disease, type C1, gene)-like 1 , Niemann-Pick C1-like protein 1 , Niemann-Pick C1-like 1 protein , Niemann-Pick C1-like protein 1-like , Niemann-Pick disease, type C1 , Niemann-Pick disease, type C1-like 1

GENE ID SPECIES
463381 Pan troglodytes
539550 Bos taurus
610398 Canis lupus familiaris
699235 Macaca mulatta
100009042 Oryctolagus cuniculus
100030165 Monodelphis domestica
100458187 Pongo abelii
100478497 Ailuropoda melanoleuca
100487339 Xenopus (Silurana) tropicalis
100515982 Sus scrofa
100590536 Nomascus leucogenys
100616532 Danio rerio
237636 Mus musculus
432367 Rattus norvegicus
29881 Homo sapiens
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