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Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Additionally we are shipping NUAK1 Proteins (10) and many more products for this protein.
Showing 10 out of 85 products:
Human Polyclonal NUAK1 Primary Antibody for ELISA, WB - ABIN451793
Kusakai, Suzuki, Ogura, Kaminishi, Esumi: Strong association of ARK5 with tumor invasion and metastasis. in Journal of experimental & clinical cancer research : CR 2004
Human Polyclonal NUAK1 Primary Antibody for IHC (p), WB - ABIN392640
Suzuki, Kusakai, Kishimoto, Lu, Ogura, Lavin, Esumi: Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein. in The Journal of biological chemistry 2002
Show all 2 Pubmed References
Hamster Polyclonal NUAK1 Primary Antibody for IHC (p), WB - ABIN392639
Niesler, Myburgh, Moore: The changing AMPK expression profile in differentiating mouse skeletal muscle myoblast cells helps confer increasing resistance to apoptosis. in Experimental physiology 2007
Show all 2 Pubmed References
The elevated ARK5 expression was closely associated with cancer metastasis and patient survival, and it seemed to function in Gastric Cancer cells migration and invasion via epithelial-mesenchymal transition alteration, together with the alteration of the mTOR/p70S6k signals, Slug and SIP1.
ARK5 confers doxorubicin resistance in hepatocellular carcinoma by inducing epithelial-mesenchymal transition.
Nuak1 downregulation decreases tau levels in a human cell line.
High NUAK1 expression are correlated with epithelial-mesenchymal transition induction in head and neck cancer.
ARK5 was upregulated in ovarian cancer tissues, promoted epithelialmesenchymal transition and inhibited miR (show MLXIP Antibodies)-1181 expression in ovarian cancer cells
MiR (show MLXIP Antibodies)-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma.
Overexpression of NUAK1 is associated with disease-free survival and overall survival in patients with gastric cancer.
Data indicate that miR (show MLXIP Antibodies)-96 suppresses the expression of (nua (show SYNE2 Antibodies)) kinase family 1 (NUAK1) by targeting its 3' untranslated region (3' UTR (show UTS2R Antibodies)).
Results indicate that NUAK1 is excessively expressed in NSCLC and plays important roles in NSCLC invasion.
Expression of NUAK1 is controlled by cyclin-dependent kinase (show CDK1 Antibodies), PLK1 (show PLK1 Antibodies), and the SCFbetaTrCP (Skp, Cullin and F-boxbetaTrCP) E3 ubiquitin ligase (show MUL1 Antibodies) complex.
Knockdown of ARK5 expression remarkably suppressed Gastric Cancer cells invasion and metastasis via regulating epithelial-mesenchymal transition, rather than proliferation in vitro and in vivo.
Nuak1 haploinsufficiency rescued the phenotypes of a tauopathy mouse model.
Study shows that LKB1 (show STK11 Antibodies) is necessary and sufficient for terminal axon branching of cortical neurons through the activation of NUAK1, an AMPK (show PRKAA1 Antibodies)-related kinase whose function during brain development was unknown.
NUAK1 knockdown reduced lung metastasis in a xenograft mouse model of nonsmall cell lung cancer.
NUAK1 and NUAK2 (show NUAK2 Antibodies) complementarily function in the apical constriction and apico-basal elongation that associate with the dorsolateral hinge point formation in cephalic neural plate during the 5- to 10-somite stages.
in human and murine cell lines, oncogenic levels of MYC (show MYC Antibodies) establish a dependence on AMPK (show PRKAA1 Antibodies)-related kinase 5 for maintaining metabolic homeostasis and for cell survival; ARK5 is an upstream regulator of AMPK (show PRKAA1 Antibodies) and limits protein synthesis via inhibition of the mammalian target of rapamycin (show FRAP1 Antibodies) 1 (mTORC1) signalling pathway
a physiological role of NUAK1 is to suppress glucose uptake through negative regulation of insulin (show INS Antibodies) signaling in oxidative muscle.
Omphk1 expression is also found in each tissue associated with the ventral body wall closure: the primary body wall composed of primitive ectoderm and each component of the secondary body wall [Omphk1]
Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in 392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR.
AMP-activated protein kinase family member 5
, AMPK-related protein kinase 5
, NUAK family SNF1-like kinase 1
, omphalocele kinase 1
, ZNUAK family, SNF1-like kinase, 1