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NUF2 encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Additionally we are shipping NUF2 Antibodies (34) and NUF2 Kits (4) and many more products for this protein.
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found LncRNA AF339813 was positively regulated by NUF2
NUF2 silencing by RANi (RNA interference) reduced the proliferation and colony formation ability of pancreatic cancer cells in vitro.
NUF2 plays a critical role in the regulation of HCC (show FAM126A Proteins) cell proliferation and apoptosis.
NUF2 was overexpressed in glioma tissues and differentially expressed in a series of glioma cell lines. Depletion of NUF2 by short-hairpin RNA inhibited cell growth in vitro and in vivo.
hnRNP K (show HNRNPK Proteins) binds to the promoter region of NUF2 and activates its transcription.
These results suggest that CDCA1 could be a prognostic biomarker and a potential therapeutic target for colorectal cancers .
these findings demonstrated that three buried glutamic acid-lysine pairs, in concert with hydrophobic interactions of core residues, provide the major specificity and stability requirements for Hec1 (show NDC80 Proteins)-Nuf2 dimerization
NDC80 (show NDC80 Proteins), NUF2 and PTN (show PTN Proteins) were significantly aberrantly overexpressed in serous adenocarcinomas.
These data suggest that the CH and tail domains of Hec1 (show NDC80 Proteins) generate essential contacts between kinetochores and microtubules in cells, whereas the Nuf2 CH domain does not.
cell growths of colorectal and gastric cancers after the siRNA-mediated knockdown of either CDCA1 or KNTC2 (show NDC80 Proteins) were significantly suppressed.
Nuf2 is a critical regulator of meiotic cell cycle progression in mammalian oocytes.
This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.
NUF2, NDC80 kinetochore complex component, homolog
, cancer/testis antigen 106
, cell division cycle associated 1
, cell division cycle-associated protein 1
, kinetochore protein Nuf2
, un-named hi2769
, unm hi2769