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In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.. Additionally we are shipping Naked Cuticle Homolog 1 (Drosophila) Proteins (3) and many more products for this protein.
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Cow (Bovine) Polyclonal NKD1 Primary Antibody for IHC, WB - ABIN2776729
Yan, Wiesmann, Rohan, Chan, Jefferson, Guo, Sakamoto, Caothien, Fuller, Reinhard, Garcia, Randazzo, Escobedo, Fantl, Williams: Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors. in Proceedings of the National Academy of Sciences of the United States of America 2001
deletion of the EF-hand from Nkd1 reduces the number of the elongating spermatids at haploid stage
Viable mice were obtained with compound mutations in the Wnt (show WNT2 Antibodies)/Dvl (show DVL1 Antibodies) pathway antagonists nkd1 and nkd2 (show NKD2 Antibodies).
Data indicate that microRNA miR (show MLXIP Antibodies)-744 activated Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway by targeting multiple negative regulators of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling, including SFRP1 (show SFRP1 Antibodies), GSK3beta (show GSK3b Antibodies), TLE3 and NKD1, and that NKD1 is a major functional target of miR (show MLXIP Antibodies)-744.
NKD1 showed significantly increased level after induction chemotherapy achieved complete remission in follow-up paired acute myeloid leukemia (show BCL11A Antibodies) patients ( p < 0.001). These findings indicated that reduced NKD1 expression is associated with unfavorable clinical outcome in cytogenetically normal acute myeloid leukemia (show BCL11A Antibodies).
Low NKD1 expression is associated with hepatocellular carcinoma.
Silencing of NKD1 significantly inhibited the proliferation and invasion of osteosarcoma cells.
Suggest that NKD1 plays an important role in invasion in human breast cancer and it appears to be a potential prognostic marker for patients with breast cancer.
Reduced NKD1 protein expression correlates with a poor prognosis in NSCLC
Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt (show WNT2 Antibodies)/Dvl (show DVL2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling
Nkd1 activity is specifically dependent on Wnt (show WNT2 Antibodies) ligand activation of the receptor. Nkd1 is recruited to the Wnt (show WNT2 Antibodies) signalosome with Dvl2 (show DVL2 Antibodies), where it becomes activated to move into the cytoplasm to interact with beta-catenin (show CTNNB1 Antibodies), inhibiting its nuclear accumulation.
Nkd1 functions as a passive antagonist of Wnt (show WNT2 Antibodies) signaling, functioning only when homeostatic levels of Wnt (show WNT2 Antibodies) signaling have been breached or when Wnt (show WNT2 Antibodies) signaling becomes destabilized.
Data demonstrate that Nkd1 binds to beta-catenin (show CTNNB1 Antibodies) and prevents its nuclear accumulation. Nkd1 function is dependent on its interaction with the cell membrane.
Nkd1 knockdown in the dorsal forerunner cells causes beta-catenin (show CTNNB1 Antibodies) nuclear localization/transcriptional activation & changes in DFC migration, Kupffer's vesicle formation, ciliogenesis, left-right patterning, & asymmetric charon expression.
data indicate that zebrafish Nkd1 and Nkd2 (show NKD2 Antibodies) function to limit both canonical and non-canonical Wnt (show WNT2 Antibodies) signaling
In the mouse, Nkd is a Dishevelled (see DVL1\; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1\; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.
naked cuticle homolog 1 (Drosophila)
, protein naked cuticle homolog 1
, Dvl-binding protein
, naked cuticle-1
, naked cuticle 1 homolog
, naked 1