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anti-Naked Cuticle Homolog 2 (Drosophila) (NKD2) Antibodies

In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.. Additionally we are shipping Naked Cuticle Homolog 2 (Drosophila) Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NKD2 72293 Q8VE28
NKD2 85409 Q969F2
NKD2 308068  
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Top anti-Naked Cuticle Homolog 2 (Drosophila) Antibodies at antibodies-online.com

Showing 10 out of 52 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB NKD2 Antibody (C-term)  western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the NKD2 antibody detected the NKD2 protein (arrow). NKD2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NKD2 Antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB Flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram) using NKD2  Antibody (C-term), followed by FITC-conjugated donkey-anti-rabbit secondary antibodies. Confocal immunofluorescent analysis of A375 cells using NKD2  Antibody (C-term), followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-NKD2 Antibody Titration: 0.2-1 ug/mlPositive Control: Jurkat cell lysate WB Suggested Anti-NKD2  Antibody Titration: 0.2-1 µg/mL  Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$221.76
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$419.83
Details
Human Rabbit FITC ICC, FACS, IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated IP, WB Immunoprecipitation of NKD2 transfected lysate using anti-NKD2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with NKD2 MaxPab mouse polyclonal antibody (B01) . Western Blot analysis of NKD2 expression in transfected 293T cell line by NKD2 MaxPab polyclonal antibody.Lane 1: NKD2 transfected lysate(34.30 KDa).Lane 2: Non-transfected lysate. 100 μL Log in to see 9 Days
$418.57
Details
Human Mouse Un-conjugated WB Western Blot analysis of NKD2 expression in transfected 293T cell line by NKD2 MaxPab polyclonal antibody.Lane 1: NKD2 transfected lysate(34.21 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 9 Days
$430.00
Details

NKD2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,
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Rat (Rattus) ,
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Top referenced anti-Naked Cuticle Homolog 2 (Drosophila) Antibodies

  1. Human Polyclonal NKD2 Primary Antibody for FACS, IF - ABIN656092 : Hu, Li, Cao, Van Raay, Smith, Willert, Solnica-Krezel, Coffey: Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane. in The Journal of biological chemistry 2010 (PubMed)
    Show all 5 references for ABIN656092

  2. Human Polyclonal NKD2 Primary Antibody for EIA, FACS - ABIN953712 : Ding, Li, Hu, Graves-Deal, Fotia, Weissman, Coffey: EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 5 references for ABIN953712

  3. Human Polyclonal NKD2 Primary Antibody for ELISA, WB - ABIN238609 : Zhang, Cagatay, Amanai, Zhang, Kline, Castrillon, Ashfaq, Oz, Wharton: Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. in Molecular and cellular biology 2007 (PubMed)

More Antibodies against Naked Cuticle Homolog 2 (Drosophila) Interaction Partners

Zebrafish Naked Cuticle Homolog 2 (Drosophila) (NKD2) interaction partners

  1. data indicate that zebrafish Nkd1 (show NKD1 Antibodies) and Nkd2 function to limit both canonical and non-canonical Wnt (show WNT2 Antibodies) signaling

Mouse (Murine) Naked Cuticle Homolog 2 (Drosophila) (NKD2) interaction partners

  1. studies provide compelling evidence that downregulation of NKD2 expression and alterations in associated regulated pathways have a significant role in driving OS tumor growth and metastasis

  2. Mouse naked cuticle 2 (mNkd2) is a direct transcriptional target of Hoxc8 (show HOXC8 Antibodies) in vivo.

Human Naked Cuticle Homolog 2 (Drosophila) (NKD2) interaction partners

  1. NKD2 is frequently methylated in human breast cancer, and the expression of NKD2 is regulated by promoter region methylation.

  2. NKD2 methylation is associated with cell differentiation, TNM (show ODZ1 Antibodies) stage and distant metastasis significantly (all P < 0.05), and the overall survival time is longer in NKD2 unmethylated group compared to NKD2 methylated group (P < 0.05).

  3. NKD2 antagonizes Wnt signaling: myristoylated NKD2 interacts with Dvl-1 at the plasma membrane, and this interaction leads to their mutual ubiquitin-mediated proteasomal degradation.

  4. NKD2 represents a candidate target of 5p amplifications in soft tissue sarcomas and might play a crucial role during the progression of this disease.

  5. Naked2 acts as a cargo recognition and targeting (CaRT) protein to ensure proper delivery, tethering, and fusion of TGF-alpha (show TGFA Antibodies)-containing vesicles to a distinct region at the basolateral surface of polarized epithelial cells.

  6. identify an EGFR (show EGFR Antibodies)-independent action of TGF-alpha (show TGFA Antibodies), in which it protects Naked2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells

Naked Cuticle Homolog 2 (Drosophila) (NKD2) Antigen Profile

Protein Summary

This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with NKD2

  • naked cuticle homolog 2b (nkd2b) antibody
  • naked cuticle 2 homolog (Drosophila) (Nkd2) antibody
  • naked cuticle homolog 2 (Drosophila) (NKD2) antibody
  • naked cuticle homolog 2 (Drosophila) (Nkd2) antibody
  • naked cuticle homolog 2a (nkd2a) antibody
  • 2210403L10Rik antibody
  • AW212591 antibody
  • Naked2 antibody
  • nkd2 antibody
  • nkd2l antibody

Protein level used designations for NKD2

naked cuticle homolog 2 , protein naked cuticle homolog 2-like , mNkd2 , naked cuticle 1 homolog , naked-2 , protein naked cuticle homolog 2 , Dvl-binding protein NKD2 , naked cuticle 2 homolog , naked 2a

GENE ID SPECIES
794221 Danio rerio
72293 Mus musculus
85409 Homo sapiens
308068 Rattus norvegicus
100049175 Danio rerio
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