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In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.. Additionally we are shipping Naked Cuticle Homolog 2 (Drosophila) Proteins (4) and many more products for this protein.
Showing 10 out of 52 products:
Human Polyclonal NKD2 Primary Antibody for FACS, IF - ABIN656092
Hu, Li, Cao, Van Raay, Smith, Willert, Solnica-Krezel, Coffey: Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane. in The Journal of biological chemistry 2010
Show all 5 references for ABIN656092
Human Polyclonal NKD2 Primary Antibody for EIA, FACS - ABIN953712
Ding, Li, Hu, Graves-Deal, Fotia, Weissman, Coffey: EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. in Proceedings of the National Academy of Sciences of the United States of America 2008
Show all 5 references for ABIN953712
Human Polyclonal NKD2 Primary Antibody for ELISA, WB - ABIN238609
Zhang, Cagatay, Amanai, Zhang, Kline, Castrillon, Ashfaq, Oz, Wharton: Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. in Molecular and cellular biology 2007
data indicate that zebrafish Nkd1 (show NKD1 Antibodies) and Nkd2 function to limit both canonical and non-canonical Wnt (show WNT2 Antibodies) signaling
studies provide compelling evidence that downregulation of NKD2 expression and alterations in associated regulated pathways have a significant role in driving OS tumor growth and metastasis
Mouse naked cuticle 2 (mNkd2) is a direct transcriptional target of Hoxc8 (show HOXC8 Antibodies) in vivo.
NKD2 is frequently methylated in human breast cancer, and the expression of NKD2 is regulated by promoter region methylation.
NKD2 methylation is associated with cell differentiation, TNM (show ODZ1 Antibodies) stage and distant metastasis significantly (all P < 0.05), and the overall survival time is longer in NKD2 unmethylated group compared to NKD2 methylated group (P < 0.05).
NKD2 antagonizes Wnt signaling: myristoylated NKD2 interacts with Dvl-1 at the plasma membrane, and this interaction leads to their mutual ubiquitin-mediated proteasomal degradation.
NKD2 represents a candidate target of 5p amplifications in soft tissue sarcomas and might play a crucial role during the progression of this disease.
Naked2 acts as a cargo recognition and targeting (CaRT) protein to ensure proper delivery, tethering, and fusion of TGF-alpha (show TGFA Antibodies)-containing vesicles to a distinct region at the basolateral surface of polarized epithelial cells.
identify an EGFR (show EGFR Antibodies)-independent action of TGF-alpha (show TGFA Antibodies), in which it protects Naked2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells
This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
naked cuticle homolog 2
, protein naked cuticle homolog 2-like
, naked cuticle 1 homolog
, protein naked cuticle homolog 2
, Dvl-binding protein NKD2
, naked cuticle 2 homolog
, naked 2a