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Naked Cuticle Homolog 2 (Drosophila) (NKD2) ELISA Kits

NKD2 encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. Additionally we are shipping Naked Cuticle Homolog 2 (Drosophila) Antibodies (52) and Naked Cuticle Homolog 2 (Drosophila) Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse NKD2 NKD2 72293 Q8VE28
Anti-Human NKD2 NKD2 85409 Q969F2
Anti-Rat NKD2 NKD2 308068  
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More ELISA Kits for Naked Cuticle Homolog 2 (Drosophila) Interaction Partners

Zebrafish Naked Cuticle Homolog 2 (Drosophila) (NKD2) interaction partners

  1. data indicate that zebrafish Nkd1 (show NKD1 ELISA Kits) and Nkd2 function to limit both canonical and non-canonical Wnt (show WNT2 ELISA Kits) signaling

Mouse (Murine) Naked Cuticle Homolog 2 (Drosophila) (NKD2) interaction partners

  1. studies provide compelling evidence that downregulation of NKD2 expression and alterations in associated regulated pathways have a significant role in driving OS tumor growth and metastasis

  2. Mouse naked cuticle 2 (mNkd2) is a direct transcriptional target of Hoxc8 (show HOXC8 ELISA Kits) in vivo.

Human Naked Cuticle Homolog 2 (Drosophila) (NKD2) interaction partners

  1. NKD2 is frequently methylated in human breast cancer, and the expression of NKD2 is regulated by promoter region methylation.

  2. NKD2 methylation is associated with cell differentiation, TNM (show ODZ1 ELISA Kits) stage and distant metastasis significantly (all P < 0.05), and the overall survival time is longer in NKD2 unmethylated group compared to NKD2 methylated group (P < 0.05).

  3. NKD2 antagonizes Wnt signaling: myristoylated NKD2 interacts with Dvl-1 at the plasma membrane, and this interaction leads to their mutual ubiquitin-mediated proteasomal degradation.

  4. NKD2 represents a candidate target of 5p amplifications in soft tissue sarcomas and might play a crucial role during the progression of this disease.

  5. Naked2 acts as a cargo recognition and targeting (CaRT) protein to ensure proper delivery, tethering, and fusion of TGF-alpha (show TGFA ELISA Kits)-containing vesicles to a distinct region at the basolateral surface of polarized epithelial cells.

  6. identify an EGFR (show EGFR ELISA Kits)-independent action of TGF-alpha (show TGFA ELISA Kits), in which it protects Naked2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells

Naked Cuticle Homolog 2 (Drosophila) (NKD2) Antigen Profile

Antigen Summary

This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with NKD2

  • naked cuticle homolog 2b (nkd2b) antibody
  • naked cuticle 2 homolog (Drosophila) (Nkd2) antibody
  • naked cuticle homolog 2 (Drosophila) (NKD2) antibody
  • naked cuticle homolog 2 (Drosophila) (Nkd2) antibody
  • naked cuticle homolog 2a (nkd2a) antibody
  • 2210403L10Rik antibody
  • AW212591 antibody
  • Naked2 antibody
  • nkd2 antibody
  • nkd2l antibody

Protein level used designations for NKD2

naked cuticle homolog 2 , protein naked cuticle homolog 2-like , mNkd2 , naked cuticle 1 homolog , naked-2 , protein naked cuticle homolog 2 , Dvl-binding protein NKD2 , naked cuticle 2 homolog , naked 2a

GENE ID SPECIES
794221 Danio rerio
72293 Mus musculus
85409 Homo sapiens
308068 Rattus norvegicus
100049175 Danio rerio
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