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Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Additionally we are shipping Nanog Homeobox Proteins (21) and Nanog Homeobox Kits (7) and many more products for this protein.
Showing 10 out of 377 products:
Human Polyclonal NANOG Primary Antibody for WB - ABIN2777175
Maimets, Neganova, Armstrong, Lako: Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells. in Oncogene 2008
Show all 4 references for ABIN2777175
Human Monoclonal NANOG Primary Antibody for IHC (p), IHC - ABIN316105
Moretti, Bellin, Jung, Thies, Takashima, Bernshausen, Schiemann, Fischer, Moosmang, Smith, Lam, Laugwitz: Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
Show all 3 references for ABIN316105
Human Polyclonal NANOG Primary Antibody for FACS, IF - ABIN388299
Kochupurakkal, Sarig, Fuchs, Piestun, Rechavi, Givol: Nanog inhibits the switch of myogenic cells towards the osteogenic lineage. in Biochemical and biophysical research communications 2007
Show all 3 references for ABIN388299
Human Polyclonal NANOG Primary Antibody for DB - ABIN390033
Freberg, Dahl, Timoskainen, Collas: Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract. in Molecular biology of the cell 2007
Show all 2 references for ABIN390033
Cow (Bovine) Polyclonal NANOG Primary Antibody for WB - ABIN2783183
Piestun, Kochupurakkal, Jacob-Hirsch, Zeligson, Koudritsky, Domany, Amariglio, Rechavi, Givol: Nanog transforms NIH3T3 cells and targets cell-type restricted genes. in Biochemical and biophysical research communications 2006
Data indicate that Nanog homeobox protein (show HOXA1 Antibodies) is important for the effects of reprogramming media.
Nanog enhances proliferation of fibroblasts through transcriptional regulation of cell cycle inhibitor (show CDKN2A Antibodies) p27 (show CDKN1B Antibodies) gene.
The different embryonic stem cells Nanog-expressing populations differ in their differentiation propensities. Nanog upregulation is not well correlated to Oct4 (show POU5F1 Antibodies), Sox2 (show SOX2 Antibodies) and Klf4 (show KLF4 Antibodies) expression, or cell cycle phase.
1After the 32-cell stage, when embryos form the blastocyst cavity, Nanog expression was upregulated mainly in ICM cells while it was repressed in the future primitive endoderm lineage in an FGF signaling-dependent manner in the later stages
Nanog is able to transform normal somatic cells into tumor cells.
NANOG represses mitochondrial oxidative phosphorylation genes, as well as reactive oxygen species generation, and activates fatty acid oxidation to support tumor initiating cell self-renewal and drug resistance.
The cellular reprogramming-promoting function of mitoflashes occurs via the upregulation of Nanog expression.
the existence of three stable steady states for Nanog levels, which are the same in all the different conditions of the cell-culture medium.
NANOG binds to GLI1 (show GLI1 Antibodies) and GLI3 (show GLI3 Antibodies) proteins and represses Hedgehog (show SHH Antibodies)-mediated transcription.
Tgif1 counterbalances the activity of core pluripotency factors, Oct4, Sox2, and Nanog, in mouse embryonic stem cells.
Stat3 (show STAT3 Antibodies) was correlated with NANOG-mediated EMT (show ITK Antibodies).
miR-760 was proved to be functional associated with NANOG via regulating its expression.
SIRT-1 and NANOG are high correlated biological markers for diagnosis and prognosis follow up in patients with adenocarcinoma.
renal cell carcinoma (show MOK Antibodies) patients with low Nanog and Oct4 (show POU5F1 Antibodies) expressions in tumor tissues had significantly higher survival rates (p < 0.05). High Nanog and Oct4 (show POU5F1 Antibodies) expressions may be potential therapeutic targets.
ANOG was regulated by extracellular IGF signaling pathway via STAT3 (show STAT3 Antibodies) phosphorylation in colorectal cancer (CRC (show CALR Antibodies)). This coincides with that IGF receptor IGF-1R (show IGF1R Antibodies) is often increasing expressed in malignant metastasis colon cancer. Taken together, our data define the crucial functions of IGF/STAT3 (show STAT3 Antibodies)/NANOG/Slug (show SNAI2 Antibodies) signaling axis in the progression of CRC (show CALR Antibodies)
Nanog is a positive regulator of cervical cancer dedifferentiation.
Data show that long intergenic non-protein coding RNA ROR may act as a competitive endogenous RNAs (ceRNAs), effectively becoming a sink for microRBA miR-145, thereby activating the derepression of core transcription factors Nanog.
ALKBH5 overexpression decreased NANOG mRNA methylation, increased NANOG levels, and increased the percentage of BCSCs, phenocopying the effect of hypoxia
Expression levels of OCT4, SOX2, and NANOG were evaluated by immunohistochemistry with tissue microarray slides of 436 OSCC, 362 corresponding tumor-adjacent normal (CTAN) tissues, and 71 normal uvula epithelium tissues.
Nanog possesses important function in BCSC.
the functional porcine NANOG that is different in chromosomal structure from mouse and human genes is a single exon gene and encodes the functional NANOG protein.
Results demonstrate that Nanog could interact with and activate other pluripotent genes both in porcine fetal fibroblasts and embryos.
Localisation of NANOG, OCT4 (show POU5F1 Antibodies), and E-CADHERIN (show CDH1 Antibodies) in porcine pre- and peri (show PLIN1 Antibodies)-implantation embryos.
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Nanog displayed relatively the same methylation levels between sperm and oocytes
Noggin, a cytokine inhibiting the BMP4 pathway, successfully upregulated the relative expression of NANOG mRNA in the ICM explants with respect to controls.
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
ES cell-associated protein 4
, early embryo specific expression NK family
, early embryo specific expression NK-type homeobox protein
, homeobox protein NANOG
, homeobox transcription factor Nanog
, homeobox transcription factor Nanog-delta 48
, homeodomain transcription factor Nanog
, homeobox transcription factor NANOG