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Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Additionally we are shipping Nanog Homeobox Proteins (21) and Nanog Homeobox Kits (5) and many more products for this protein.
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Human Polyclonal NANOG Primary Antibody for WB - ABIN2777175
Maimets, Neganova, Armstrong, Lako: Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells. in Oncogene 2008
Show all 4 references for ABIN2777175
Human Polyclonal NANOG Primary Antibody for FACS, IF - ABIN388299
Kochupurakkal, Sarig, Fuchs, Piestun, Rechavi, Givol: Nanog inhibits the switch of myogenic cells towards the osteogenic lineage. in Biochemical and biophysical research communications 2007
Show all 3 references for ABIN388299
Human Polyclonal NANOG Primary Antibody for DB, IF - ABIN390032
Freberg, Dahl, Timoskainen, Collas: Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract. in Molecular biology of the cell 2007
Show all 2 references for ABIN390032
Human Polyclonal NANOG Primary Antibody for WB - ABIN2792523
Piestun, Kochupurakkal, Jacob-Hirsch, Zeligson, Koudritsky, Domany, Amariglio, Rechavi, Givol: Nanog transforms NIH3T3 cells and targets cell-type restricted genes. in Biochemical and biophysical research communications 2006
Nanog is able to transform normal somatic cells into tumor cells.
NANOG represses mitochondrial oxidative phosphorylation genes, as well as reactive oxygen species generation, and activates fatty acid oxidation to support tumor initiating cell self-renewal and drug resistance.
The cellular reprogramming-promoting function of mitoflashes occurs via the upregulation of Nanog expression.
the existence of three stable steady states for Nanog levels, which are the same in all the different conditions of the cell-culture medium.
NANOG binds to GLI1 (show GLI1 Antibodies) and GLI3 (show GLI3 Antibodies) proteins and represses Hedgehog (show SHH Antibodies)-mediated transcription.
Tgif1 counterbalances the activity of core pluripotency factors, Oct4, Sox2, and Nanog, in mouse embryonic stem cells.
TLR4 (show TLR4 Antibodies) signaling via NANOG cooperates with STAT3 (show STAT3 Antibodies) to activate Twist1 (show TWIST1 Antibodies) and promote formation of tumor-initiating stem-like cells in livers of mice.
Pluripotency transcription factors Nanog and Oct4 (show POU5F1 Antibodies) positively modulate Sod2 (show SOD2 Antibodies) gene transcription in induced pluripotent stem cells.
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers
Forced expression of Nanog (and Esrrb) resulted in the dispensability of nucleostemin (show E2IG3 Antibodies) expression in embryonic stem cells.
the disruption of Nanog expression results in less proliferation, invasiveness, migration, more chemosensitivity and reversal of EMT in HepG2 cells, by which Nanog plays crucial roles in influencing the malignant phenotype of HepG2 cells.
The promoter activity of Nanog and Oct4 (show POU5F1 Antibodies) were upregulated, and beta-catenin (show CTNNB1 Antibodies) was observed to bind to these promoters during H. pylori infection, while a Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) inhibitor suppressed promoter activity and binding.
ectopic expression of Oct-4 (show POU5F1 Antibodies) gene in hAFMSCs with high self-renewal ability could upregulate Nanog and Sox-2 (show SOX2 Antibodies) gene expression
Nanog is an oncogene (show RAB1A Antibodies) with multiple roles in promoting tumorigenesis and metastasis
The positive correlation among Oct-4 (show POU5F1 Antibodies), Nanog, and beta-catenin (show CTNNB1 Antibodies) suggests their coordinated role in maintaining proliferation in oral carcinoma cells.
Oct3/4 (show POU5F1 Antibodies) and Nanog represent probable CSC markers in HNSCC, which contribute to the development of DNM (show DNM1 Antibodies) in part by enhancing cell motility and invasiveness.
The outcomes of this study, for the first time, unravels the importance of particular genomic features in Nanog gene evolution paving roads toward better understanding of stem cell development and human targeted disorder therapy
Magnetofection-mediated NANOG delivery increased proliferation and enhanced the differentiation of hair follicle derived mesenchymal stem cells into smooth muscle cells.
NANOG potentiates the molecular circuitry of tumorigenesis, and thus may represent a novel therapeutic target or biomarker for the diagnosis, prognosis, and treatment outcome of cancer.
NANOG may play a significant role in carcinogenesis via its activation of c-Jun (show JUN Antibodies) expression.
the functional porcine NANOG that is different in chromosomal structure from mouse and human genes is a single exon gene and encodes the functional NANOG protein.
Results demonstrate that Nanog could interact with and activate other pluripotent genes both in porcine fetal fibroblasts and embryos.
Localisation of NANOG, OCT4 (show POU5F1 Antibodies), and E-CADHERIN (show CDH1 Antibodies) in porcine pre- and peri (show PLIN1 Antibodies)-implantation embryos.
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Nanog displayed relatively the same methylation levels between sperm and oocytes
Noggin, a cytokine inhibiting the BMP4 pathway, successfully upregulated the relative expression of NANOG mRNA in the ICM explants with respect to controls.
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
ES cell-associated protein 4
, early embryo specific expression NK family
, early embryo specific expression NK-type homeobox protein
, homeobox protein NANOG
, homeobox transcription factor Nanog
, homeobox transcription factor Nanog-delta 48
, homeodomain transcription factor Nanog
, homeobox transcription factor NANOG