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Nardilysin (N-Arginine Dibasic Convertase) Proteins (NRD1)

NRD1 encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. Additionally we are shipping NRD1 Antibodies (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NRD1 4898 O43847
Rat NRD1 NRD1 25499 P47245
Mouse NRD1 NRD1 230598 Q8BHG1
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Top NRD1 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NRD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Nardilysin (N-Arginine Dibasic Convertase) (NRD1) Interaction Partners

Human Nardilysin (N-Arginine Dibasic Convertase) (NRD1) interaction partners

  1. MRNA expression of NRD1 was upregulated in 56% of ESCC tissue samples.

  2. This study demonistrated that alcohol-dependent reduction of nardilysin in cell culture and nervous tissue points to an implication of the enzyme in the pathophysiology of alcoholism.

  3. possible roles of nardilysin in Alzheimer disease, Down syndrome, schizophrenia, mood disorders, alcohol abuse, heroin addiction and cancer; show that nardilysin is a Janus-faced enzyme with regard to brain pathology-- probably neuropathogenic in some diseases, but neuroprotective in others [review]

  4. SH-SY5Y cells, stably transfected with green fluorescent protein-tagged-p42 (show EPB42 Proteins)(IP4) show enhanced NRD (show PRDM1 Proteins) protein expression already at an earlier time point after retinoic acid stimulation.

  5. NRD1 interacts with p53 (show TP53 Proteins) mutant R273H

  6. These results demonstrate that gastric cancer cell growth is maintained by autonomous TNF-alpha (show TNF Proteins)-NF-kappaB (show NFKB1 Proteins) and IL-6 (show IL6 Proteins)-STAT3 (show STAT3 Proteins) signalling, and that NRDc and ADAM proteases turn on these signalling cascades by stimulating ectodomain shedding of TNF-alpha (show TNF Proteins).

  7. Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation.

  8. Several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample for KIAA0040, NRD1 and THSD7B, respectively.

  9. Tubulin (show TUBB Proteins) potentiates the interaction of the metalloendopeptidase (show THOP1 Proteins) nardilysin with the neuronal scaffold protein (show HOMER1 Proteins) p42IP4 (show ADAP1 Proteins)/centaurin-alpha1 (ADAP1 (show ADAP1 Proteins)).

  10. nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF (show HBEGF Proteins))

Mouse (Murine) Nardilysin (N-Arginine Dibasic Convertase) (NRD1) interaction partners

  1. deletion of nardilysin prevents the development of diet-induced steatohepatitis and liver fibrogenesis

  2. Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation.

  3. The use of proteolysis to study the structure of nardilysin.

  4. Studies extend the range of potential substrates for nardilysin and further substantiate that nardilysin is a true peptidase.

  5. miniglucagon-generating endopeptidase is composed of NRDc and aminopeptidase B (show RNPEP Proteins) acting sequentially

  6. role for nardilysin in oocyte meiosis through its dynamic translocation from cytosol to nucleus, and then to the spindle apparatus

  7. NRDc regulates axonal maturation and myelination in the nervous system, in part, through the modulation of NRG1 (show NRG1 Proteins) shedding

  8. The acidic stretch of nardilysin, expressed as a fusion protein with glutathione S-transferase (show GSTa2 Proteins) and compared to the native enzyme with respect to spermine binding, functions as an autonomous domain.

NRD1 Protein Profile

Protein Summary

This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NRD1

  • nardilysin (N-arginine dibasic convertase) (NRD1)
  • nardilysin (N-arginine dibasic convertase) (nrd1)
  • nardilysin (CpipJ_CPIJ002524)
  • nardilysin (Tsp_03755)
  • nardilysin 1 (Nrd1)
  • nardilysin, N-arginine dibasic convertase, NRD convertase 1 (Nrd1)
  • 2600011I06Rik protein
  • AI875733 protein
  • DKFZp459N143 protein
  • hNRD1 protein
  • hNRD2 protein
  • Nardilysin protein
  • NRD-C protein
  • NRD1 protein
  • NRDC protein
  • si:dkey-171o17.4 protein

Protein level used designations for NRD1

nardilysin , nardilysin (N-arginine dibasic convertase) , NRD convertase , N-arginine dibasic convertase , NRD-C , N-arginine dibasic convertase 1 , nardilysin 1 (N-arginine dibasic convertase) , nardilysin, N-arginine dibasic convertase 1 , nardilysin, N-arginine dibasic convertase, NRD convertase 1

GENE ID SPECIES
424635 Gallus gallus
456852 Pan troglodytes
475354 Canis lupus familiaris
552055 Apis mellifera
557565 Danio rerio
6033791 Culex quinquefasciatus
10910482 Trichinella spiralis
100173985 Pongo abelii
100452780 Pongo abelii
100514906 Sus scrofa
4898 Homo sapiens
25499 Rattus norvegicus
230598 Mus musculus
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