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Nasal Embryonic LHRH Factor Proteins (NELF)

The protein encoded by NELF is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons.

list all proteins Gene Name GeneID UniProt
Human NELF NELF 26012 Q6X4W1
Mouse NELF NELF 56876 Q99NF2
Rat NELF NELF 117536 Q9EPI6
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More Proteins for Nasal Embryonic LHRH Factor (NELF) Interaction Partners

Zebrafish Nasal Embryonic LHRH Factor (NELF) interaction partners

  1. These results suggest that Nelf is an important factor in the developmental migration and projection of GnRH3 neurons in zebrafish.

Human Nasal Embryonic LHRH Factor (NELF) interaction partners

  1. The nuclear and non-nuclear NELF variant transcripts and proteins were identified, explaining variable NELF cellular localization.

  2. a model in which NELF recruits Pcf11 and NCoR1-GPS2-HDAC3 to paused RNAP II, reinforcing repression of HIV transcription and establishing a critical checkpoint for HIV transcription and latency.

  3. NELF is associated with normosmic idiopathic hypogonadotropic hypogonadism and Kallmann syndrome, either singly or in combination with a mutation in another gene.

  4. our findings implicate NELF as a nuclear protein involved in the developmental function of the reproductive axis.

  5. 12% of Kallman syndrome males have KAL1 (show KAL1 Proteins) deletions, but intragenic deletions of the FGFR1 (show FGFR1 Proteins), GNRH1 (show GNRH1 Proteins), GNRHR (show GNRHR Proteins), GPR54 and NELF genes are uncommon in Idiopathic hypogonadotropic hypogonadism/Kallman syndrome.

Mouse (Murine) Nasal Embryonic LHRH Factor (NELF) interaction partners

  1. BDNF (show BDNF Proteins) application can rescue the morphological deficits in hippocampal pyramidal neurons devoid of Jacob. Taken together, the data suggest that the absence of Jacob in early development interrupts a positive feedback loop between BDNF (show BDNF Proteins) signaling

  2. NELF knockout is associated with impaired pubertal development and subfertility.

  3. Findings strongly indicate that NELF is part of the PPARalpha (show PPARA Proteins)-mediated transcription regulatory network that maintains metabolic homeostasis in cardiomyocytes.

  4. Jacob operates as a mobile hub that docks NMDA receptor-derived signalosomes to nuclear target sites.

  5. The nuclear and non-nuclear NELF variant transcripts and proteins were identified, explaining variable NELF cellular localization.

  6. Study demonstrates that Jacob is a protein messenger that encodes the origin of synaptic versus extrasynaptic N-methyl-D-aspartate-receptors signals and delivers them to the nucleus.

  7. Calpain-mediated clipping of the myristoylated N terminus of Jacob is required for its nuclear translocation after N-methyl-d-aspartate receptor (show GRIN1 Proteins) activation

Nasal Embryonic LHRH Factor (NELF) Protein Profile

Protein Summary

The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NELF

  • NMDA receptor synaptonuclear signaling and neuronal migration factor b (nsmfb)
  • nasal embryonic LHRH factor (NELF)
  • nasal embryonic LHRH factor (nelf)
  • NMDA receptor synaptonuclear signaling and neuronal migration factor (NSMF)
  • NMDA receptor synaptonuclear signaling and neuronal migration factor (Nsmf)
  • HH9 protein
  • Jac protein
  • Jacob protein
  • Nelf protein
  • nelfb protein
  • nsmf protein
  • rp11-48c7.1 protein
  • si:ch73-239f21.1 protein

Protein level used designations for NELF

NMDA receptor synaptonuclear signaling and neuronal migration factor , nasal embryonic LHRH factor b , nasal embryonic luteinizing hormone-releasing hormone factor , nasal embryonic LHRH factor , nasal embryonic luteinizing hormone-releasing hormone factor-like , juxtasynaptic attractor of caldendrin on dendritic boutons protein

GENE ID SPECIES
569891 Danio rerio
615854 Bos taurus
100144675 Xenopus (Silurana) tropicalis
100387310 Callithrix jacchus
606797 Canis lupus familiaris
417260 Gallus gallus
26012 Homo sapiens
56876 Mus musculus
117536 Rattus norvegicus
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