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The protein encoded by NELF is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons.
These results suggest that Nelf is an important factor in the developmental migration and projection of GnRH3 neurons in zebrafish.
The nuclear and non-nuclear NELF variant transcripts and proteins were identified, explaining variable NELF cellular localization.
a model in which NELF recruits Pcf11 and NCoR1-GPS2-HDAC3 to paused RNAP II, reinforcing repression of HIV transcription and establishing a critical checkpoint for HIV transcription and latency.
NELF is associated with normosmic idiopathic hypogonadotropic hypogonadism and Kallmann syndrome, either singly or in combination with a mutation in another gene.
our findings implicate NELF as a nuclear protein involved in the developmental function of the reproductive axis.
12% of Kallman syndrome males have KAL1 (show KAL1 Proteins) deletions, but intragenic deletions of the FGFR1 (show FGFR1 Proteins), GNRH1 (show GNRH1 Proteins), GNRHR (show GNRHR Proteins), GPR54 and NELF genes are uncommon in Idiopathic hypogonadotropic hypogonadism/Kallman syndrome.
BDNF (show BDNF Proteins) application can rescue the morphological deficits in hippocampal pyramidal neurons devoid of Jacob. Taken together, the data suggest that the absence of Jacob in early development interrupts a positive feedback loop between BDNF (show BDNF Proteins) signaling
NELF knockout is associated with impaired pubertal development and subfertility.
Findings strongly indicate that NELF is part of the PPARalpha (show PPARA Proteins)-mediated transcription regulatory network that maintains metabolic homeostasis in cardiomyocytes.
Jacob operates as a mobile hub that docks NMDA receptor-derived signalosomes to nuclear target sites.
Study demonstrates that Jacob is a protein messenger that encodes the origin of synaptic versus extrasynaptic N-methyl-D-aspartate-receptors signals and delivers them to the nucleus.
Calpain-mediated clipping of the myristoylated N terminus of Jacob is required for its nuclear translocation after N-methyl-d-aspartate receptor (show GRIN1 Proteins) activation
The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene.
NMDA receptor synaptonuclear signaling and neuronal migration factor
, nasal embryonic LHRH factor b
, nasal embryonic luteinizing hormone-releasing hormone factor
, nasal embryonic LHRH factor
, nasal embryonic luteinizing hormone-releasing hormone factor-like
, juxtasynaptic attractor of caldendrin on dendritic boutons protein