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Nascent Polypeptide Associated Complex alpha 1 (NACa1) ELISA Kits

The protein encoded by NACa1 associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). Additionally we are shipping Nascent Polypeptide Associated Complex alpha 1 Proteins (10) and Nascent Polypeptide Associated Complex alpha 1 Antibodies (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse NACa1 NACa1 17938 P70670,Q60817
Anti-Human NACa1 NACa1 4666 Q13765
Anti-Rat NACa1 NACa1 288770  
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More ELISA Kits for Nascent Polypeptide Associated Complex alpha 1 Interaction Partners

Mouse (Murine) Nascent Polypeptide Associated Complex alpha 1 (NACa1) interaction partners

  1. the skNAC-Smyd1 complex is involved in transcriptional regulation both via the control of histone methylation and histone (de)acetylation.

  2. skNAC binds to the E3 SUMO ligase mammalian Mms21/Nse2 (show NSMCE2 ELISA Kits) and that knockdown of Nse2 (show NSMCE2 ELISA Kits) expression inhibits specific aspects of myogenic differentiation, accompanied by a partial blockade of the nuclear-to-cytoplasmic translocation of the skNAC-Smyd1 complex

  3. depletion of alphaNAC in multiple types of cancer cells induce typical apoptotic cell death. This anti-apoptotic function is mediated by the FADD/c-Jun N-terminal kinase pathway.

  4. We propose that maximal transcriptional repression by FIAT requires its interaction with SUMOylated, HDAC2-interacting aNAC

  5. Altered gene dosages for Galphas (show GNAS ELISA Kits) and alpha- NAC in compound heterozygous mice result in reduced bone mass, increased numbers of osteocytes, and enhanced expression of Sost (show SOST ELISA Kits).

  6. The bone phenotype of compound Naca(+/-); Fiat (show TXLNG ELISA Kits)(+/-) heterozygotes confirms that FIAT (show TXLNG ELISA Kits) and alphaNAC are part of a common genetic pathway and support a role for the FIAT (show TXLNG ELISA Kits)/alphaNAC interaction in normal bone physiology.

  7. data suggest that skNAC controls myoblast migration and sarcomere architecture in a calpain-dependent manner

  8. nascent polypeptide associated complex regulates specific aspects of myogenesis.

  9. The muscle-specific transcription factor skNAC is the major binding partner for Smyd1 in the developing heart.

  10. Inhibition of alpha NAC nuclear translocation results in an osteopenic phenotype caused by reduced expression of osteocalcin (show BGLAP ELISA Kits) and type I collagen, accelerated mineralization, and immature woven-bone formation.

Zebrafish Nascent Polypeptide Associated Complex alpha 1 (NACa1) interaction partners

  1. Results demonstrate that skNAC plays a vital role in myofibril assembly and function during muscle cell differentiation.

Human Nascent Polypeptide Associated Complex alpha 1 (NACa1) interaction partners

  1. depletion of alphaNAC in multiple types of cancer cells induce typical apoptotic cell death. This anti-apoptotic function is mediated by the FADD/c-Jun N-terminal kinase pathway.

  2. Low NACA expression is associated with rhabdomyosarcoma.

  3. [review] First evidence of a functional interaction between ATF4 (show ATF4 ELISA Kits), FIAT (factor-inhibiting ATF4-mediated transcription (show TXLNG ELISA Kits)) and alphaNAC (nascent polypeptide-associated complex and coactivator alpha).

  4. NACA gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma.

  5. identified a region in the NAC domain of the human NAC alpha-subunit (show POLG ELISA Kits) as a new nucleic acid-binding region, which is blocked from binding nucleic acids in the heterodimeric complex by a helix region in the beta-subunit (show POLG ELISA Kits)

  6. Human brain nascent polypeptide-associated complex alpha subunit is decreased in patients with Alzheimer' s disease and Down syndrome.

  7. a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen

  8. virtual Northern blots to analyze expression of NACA and ANX2 (show ANXA2 ELISA Kits) in progenitor cultures of nine children with Juvenile myelomonocytic leukemia and five healthy individuals

  9. Altogether, these results characterize NACA as a new factor involved in the positive regulation of human erythroid-cell differentiation.

  10. Alpha NAC downregulation in hypoxic cells or NAC ablation by NAC short-interfering RNA (siRNA) leads to the initiation of ER stress responses, which results in caspase (show CASP3 ELISA Kits)-dependent apoptosis.

Nascent Polypeptide Associated Complex alpha 1 (NACa1) Antigen Profile

Antigen Summary

The protein encoded by this gene associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). NAC binds to nascent proteins as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. However, nascent proteins with an exposed signal peptide will not be bound by the encoded protein, enabling them to bind the SRP and enter the secretory pathway. This protein has been determined to be an IgE autoantigen in atopic dermatitis patients. Several transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with NACa1

  • nascent polypeptide-associated complex alpha polypeptide (Naca) antibody
  • nascent polypeptide-associated complex alpha polypeptide (naca) antibody
  • nascent polypeptide-associated complex alpha subunit (NACA) antibody
  • nascent polypeptide-associated complex alpha subunit (Naca) antibody
  • AL022831 antibody
  • AL024382 antibody
  • Gm1878 antibody
  • ik:tdsubc_2b5 antibody
  • mKIAA0363 antibody
  • NACA1 antibody
  • nkn antibody
  • skNAC antibody
  • tdsubc_2b5 antibody
  • xx:tdsubc_2b5 antibody

Protein level used designations for NACa1

alpha-NAC, muscle-specific form , alpha-NAC/1.9.2 , nascent polypeptide-associated complex alpha subunit , nascent polypeptide-associated complex subunit alpha , nascent polypeptide-associated complex subunit alpha, muscle-specific form , NAC-alpha , alpha-NAC , no knack , sknac , nascent-polypeptide-associated complex alpha polypeptide

GENE ID SPECIES
17938 Mus musculus
195823 Danio rerio
4666 Homo sapiens
513312 Bos taurus
288770 Rattus norvegicus
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