You are viewing an incomplete version of our website. Please click to reload the website as full version.

Nascent Polypeptide Associated Complex alpha 1 Proteins (NACa1)

The protein encoded by NACa1 associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). Additionally we are shipping Nascent Polypeptide Associated Complex alpha 1 Antibodies (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NACa1 17938 P70670,Q60817
NACa1 4666 Q13765
Rat NACa1 NACa1 288770  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Nascent Polypeptide Associated Complex alpha 1 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,531.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,531.83
Details
Yeast REACT_Cichlidae His tag   1 mg Log in to see 56 to 66 Days
$2,531.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NACa1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

Top referenced Nascent Polypeptide Associated Complex alpha 1 Proteins

  1. Human NACa1 Protein expressed in Escherichia coli (E. coli) - ABIN667605 : Lopez, Stuhl, Fichelson, Dubart-Kupperschmitt, St Arnaud, Galindo, Murati, Berda, Dubreuil, Gomez: NACA is a positive regulator of human erythroid-cell differentiation. in Journal of cell science 2005 (PubMed)
    Show all 2 references for ABIN667605

More Proteins for Nascent Polypeptide Associated Complex alpha 1 (NACa1) Interaction Partners

Mouse (Murine) Nascent Polypeptide Associated Complex alpha 1 (NACa1) interaction partners

  1. the skNAC-Smyd1 (show SMYD1 Proteins) complex is involved in transcriptional regulation both via the control of histone methylation and histone (de)acetylation.

  2. skNAC binds to the E3 SUMO ligase mammalian Mms21/Nse2 (show NSMCE2 Proteins) and that knockdown of Nse2 (show NSMCE2 Proteins) expression inhibits specific aspects of myogenic differentiation, accompanied by a partial blockade of the nuclear-to-cytoplasmic translocation of the skNAC-Smyd1 (show SMYD1 Proteins) complex

  3. depletion of alphaNAC in multiple types of cancer cells induce typical apoptotic cell death. This anti-apoptotic function is mediated by the FADD/c-Jun N-terminal kinase pathway.

  4. We propose that maximal transcriptional repression by FIAT (show TXLNG Proteins) requires its interaction with SUMOylated, HDAC2 (show HDAC2 Proteins)-interacting aNAC (show NACa2 Proteins)

  5. Altered gene dosages for Galphas (show GNAS Proteins) and alpha- NAC in compound heterozygous mice result in reduced bone mass, increased numbers of osteocytes, and enhanced expression of Sost (show SOST Proteins).

  6. The bone phenotype of compound Naca(+/-); Fiat (show TXLNG Proteins)(+/-) heterozygotes confirms that FIAT (show TXLNG Proteins) and alphaNAC are part of a common genetic pathway and support a role for the FIAT (show TXLNG Proteins)/alphaNAC interaction in normal bone physiology.

  7. data suggest that skNAC controls myoblast migration and sarcomere architecture in a calpain-dependent manner

  8. nascent polypeptide associated complex regulates specific aspects of myogenesis.

  9. The muscle-specific (show EIF3K Proteins) transcription factor skNAC is the major binding partner for Smyd1 (show SMYD1 Proteins) in the developing heart.

  10. Inhibition of alpha NAC nuclear translocation results in an osteopenic phenotype caused by reduced expression of osteocalcin (show BGLAP Proteins) and type I collagen, accelerated mineralization, and immature woven-bone formation.

Zebrafish Nascent Polypeptide Associated Complex alpha 1 (NACa1) interaction partners

  1. Results demonstrate that skNAC plays a vital role in myofibril assembly and function during muscle cell differentiation.

Human Nascent Polypeptide Associated Complex alpha 1 (NACa1) interaction partners

  1. depletion of alphaNAC in multiple types of cancer cells induce typical apoptotic cell death. This anti-apoptotic function is mediated by the FADD/c-Jun N-terminal kinase pathway.

  2. Low NACA expression is associated with rhabdomyosarcoma.

  3. [review] First evidence of a functional interaction between ATF4 (show ATF4 Proteins), FIAT (factor-inhibiting ATF4-mediated transcription (show TXLNG Proteins)) and alphaNAC (nascent polypeptide-associated complex and coactivator alpha).

  4. NACA gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma.

  5. identified a region in the NAC domain of the human NAC alpha-subunit (show POLG Proteins) as a new nucleic acid-binding region, which is blocked from binding nucleic acids in the heterodimeric complex by a helix region in the beta-subunit (show POLG Proteins)

  6. Human brain nascent polypeptide-associated complex alpha subunit is decreased in patients with Alzheimer' s disease and Down syndrome.

  7. a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen

  8. virtual Northern blots to analyze expression of NACA and ANX2 (show ANXA2 Proteins) in progenitor cultures of nine children with Juvenile myelomonocytic leukemia and five healthy individuals

  9. Altogether, these results characterize NACA as a new factor involved in the positive regulation of human erythroid-cell differentiation.

  10. Alpha NAC downregulation in hypoxic cells or NAC ablation by NAC short-interfering RNA (siRNA) leads to the initiation of ER stress responses, which results in caspase (show CASP3 Proteins)-dependent apoptosis.

Nascent Polypeptide Associated Complex alpha 1 (NACa1) Protein Profile

Protein Summary

The protein encoded by this gene associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). NAC binds to nascent proteins as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. However, nascent proteins with an exposed signal peptide will not be bound by the encoded protein, enabling them to bind the SRP and enter the secretory pathway. This protein has been determined to be an IgE autoantigen in atopic dermatitis patients. Several transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with NACa1

  • nascent polypeptide-associated complex alpha polypeptide (Naca)
  • nascent polypeptide-associated complex alpha polypeptide (naca)
  • nascent polypeptide-associated complex alpha subunit (NACA)
  • nascent polypeptide-associated complex alpha subunit (Naca)
  • AL022831 protein
  • AL024382 protein
  • Gm1878 protein
  • ik:tdsubc_2b5 protein
  • mKIAA0363 protein
  • NACA1 protein
  • nkn protein
  • skNAC protein
  • tdsubc_2b5 protein
  • xx:tdsubc_2b5 protein

Protein level used designations for NACa1

alpha-NAC, muscle-specific form , alpha-NAC/1.9.2 , nascent polypeptide-associated complex alpha subunit , nascent polypeptide-associated complex subunit alpha , nascent polypeptide-associated complex subunit alpha, muscle-specific form , NAC-alpha , alpha-NAC , no knack , sknac , nascent-polypeptide-associated complex alpha polypeptide

GENE ID SPECIES
17938 Mus musculus
195823 Danio rerio
4666 Homo sapiens
513312 Bos taurus
288770 Rattus norvegicus
Selected quality suppliers for Nascent Polypeptide Associated Complex alpha 1 Proteins (NACa1)
Did you look for something else?