Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) Proteins (NPR1)

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). Additionally we are shipping NPR1 Antibodies (88) and NPR1 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NPR1 4881 P16066
NPR1 24603 P18910
NPR1 18160 P18293
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Top NPR1 Proteins at antibodies-online.com

Showing 8 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
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Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Log in to see 11 Days
$341.00
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Yeast Human His tag   50 μg Log in to see 8 to 11 Days
$341.00
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$860.20
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,234.00
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Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$624.55
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NPR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , , ,
Rat (Rattus)

Mouse (Murine)
,

More Proteins for Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) Interaction Partners

Human Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

  1. The results indicate that the inhibition of NPRA suppresses gastric cancer development and targeting NPRA may represent a promising strategy for the treatment of gastric cancer.

  2. Data suggest that signaling via ANP (show NPPA Proteins)/ANPR (atrial natriuretic factor/ANP (show NPPA Proteins) receptor (show PPP5C Proteins)) in vascular endothelial cells activates PAK4 (p21-activated kinase 4 (show PAK4 Proteins)) and CCM2 (cerebral cavernous malformation 2 (show CCM2 Proteins) protein), resulting in phosphorylation of MLC (myosin light chain), cytoskeletal reorganization, and cell spreading; kinase homology domain of ANPRA (guanylyl cyclase-A) activates downstream targets of ANP (show NPPA Proteins)/ANPR signaling.

  3. After ligand binding, NPRA is rapidly internalized and trafficked from the cell surface into endosomes, Res and lysosomes, with concurrent generation of intracellular cyclic GMP (show NT5C2 Proteins) in HEK (show EPHA3 Proteins)-293 cells.

  4. Data suggest up-regulation of NPRA in skeletal muscle (SM) correlates with whole-body insulin sensitiv (show INS Proteins)ity; NPRA is down-regulated in SM in obese subjects compared to normal controls; NPRA in SM is up-regulated in response to diet-induced weight loss.

  5. In this review we highlight the mechanisms by which NPR-A affects signaling pathways involved in inflammation and cancer, and we discuss its potential as a novel target in inflammation, cancer, and cancer-related inflammation

  6. NPRA was detected in E11.5 cardiac progenitor cells.

  7. Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A/-B activator.

  8. High NPR1 expression is associated with esophageal squamous cell carcinomas.

  9. Molecular dynamics analysis indicated decreases in the values of Van (show TNIP1 Proteins) der (show GDF3 Proteins) Waals, electrostatic energy and potential energy of NPRB (show NPR2 Proteins)/Vasonatrin peptide compared to NPRA/Vasonatrin peptide.

  10. ACNP stimulated both human natriuretic peptide receptors (NPRs), NPRA and NPRB (show NPR2 Proteins), as potent as their native ligands in receptor transfected cells.

Mouse (Murine) Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

  1. The results indicate that the inhibition of NPRA suppresses gastric cancer development and targeting NPRA may represent a promising strategy for the treatment of gastric cancer.

  2. KLF10 and atrial natriuretic peptide (show NPPA Proteins)/NPRA in exerting influences on chronic pulmonary disease pathogenesis

  3. Treatment of the haplotype Npr1(+/-) mice with histone deacetylase (show HDAC1 Proteins) inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1 (show HDAC1 Proteins)/2, NF-kappaB (show NFKB1 Proteins) (p65 (show NFkBP65 Proteins)), and STAT1 (show STAT1 Proteins).

  4. Data suggest that the negative inhibition of P2X3R activity by the BNP/NPR-A pathway results in a decreased P2X3R-mediated excitability of trigeminal neurons in wildetype cultures. In familial hemiplegic migraine type-1 model cultures, however, lack of efficient P2X3Rs downregulation contributes to the neuronal hyperexcitability phenotype.

  5. The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis.

  6. Conclude that postnatal cardiac hyperplasia in mice with global GC-A (show GUCA1A Proteins) inactivation is provoked by systemic alterations rather than direct regulation of cardiac myocyte proliferation.

  7. Data (including data from studies in knockout mice) suggest expression of ANP (show NPPA Proteins)/BNP/GC-A (show GUCA1A Proteins) (atrial natriuretic peptide (show NPPA Proteins), brain natriuretic peptide (show BNP Proteins), and guanylyl cyclase-A) is important in embryonic neovascularization and organogenesis.

  8. Suggest that the FQQI motif is essential for the internalization and subcellular trafficking of NPRA during the hormone signaling process in intact mesangial cells.

  9. Data suggest activation of skeletal muscle (SM) Npra is important for maintenance of long-term insulin (show INS Proteins) sensitivity; up-regulation of Npra signal transduction in SM (that was reduced by obesity) prevents glucose intolerance and diabetes type 2.

  10. these findings define a novel epigenetic regulatory mechanism that governs Npr1 gene transcription.

Arabidopsis thaliana Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

  1. We identified a rice mutant in the Kitaake genetic background with a frameshift mutation in crk10; this mutant also displays a compromised immune response highlighting the important role of crk10. We also show that elevated levels of NH1 expression lead to enhanced CRK10 expression and that the rice TGA2.1 protein binds to the CRK10 promoter.

  2. Green tissue-specific expression of Arabidopsis thaliana NPR1 is an effective strategy for controlling the sheath blight pathogen (Rhizoctonia solani) in rice. The present work in rice can be extended to other crop plants severely damaged by the pathogen.

  3. The results revealed a tight correlation between sequential salicylic acid (SA) and sic acid (ABA) signaling and dynamic changes in NPR1 protein levels and NPR1-dependent transcription in plant immune responses.

  4. Crosstalk between nitric oxide and glutathione is integral to the NPR1-dependent defense signaling pathway.

  5. The authors show that sumoylation of NPR1 by SUMO3 (show SUMO3 Proteins) activates defense gene expression by switching NPR1's association with the WRKY transcription repressors to TGA (show TBX1 Proteins) transcription activators.

  6. Altogether, our results indicate that AR156 can induce SAR by the SA-signaling pathways in an NPR1-dependent manner and involves multiple PTI components.

  7. NPR1-dependent salicylic acid signaling is not involved in the elevated carbon dioxide-induced heat shock tolerance.

  8. NPR1-dependent salicylic acid (SA) signalling is central to the salt and oxidative stress tolerance in Arabidopsis.

  9. MPK6-mediated WRKY6 and Trx h5 transcriptional activation co-regulated the expression of the NPR1 gene and the monomerization of NPR1 protein, allowing it to enter the nucleus, thereby promoting salicylic acid-induced leaf senescence.

  10. AtNPR1, AtGA2, and AtPR-5, encoding specific components involved in salicylic acid regulation, synthesis, and signaling, are overexpressed in soybean roots, resistance to soybean cyst nematode is enhanced.

NPR1 Protein Profile

Protein Summary

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994

Gene names and symbols associated with NPR1

  • natriuretic peptide receptor 1 (NPR1)
  • natriuretic peptide receptor 1 (Npr1)
  • natriuretic peptide receptor 1a (npr1a)
  • regulatory protein (NPR1) (NPR1)
  • AI893888 protein
  • ANPa protein
  • Anpra protein
  • ARABIDOPSIS NONEXPRESSER OF PR GENES 1 protein
  • ATNPR1 protein
  • F15H21.6 protein
  • F15H21_6 protein
  • GC-A protein
  • Gca protein
  • GUC2A protein
  • GUCY2A protein
  • NIM1 protein
  • NON-INDUCIBLE IMMUNITY 1 protein
  • NONEXPRESSER OF PR GENES 1 protein
  • NPR-A protein
  • Npra protein
  • Pndr protein
  • REGULATORY PROTEIN NPR1 protein
  • SAI1 protein
  • SALICYLIC ACID INSENSITIVE 1 protein
  • sGC protein
  • si:dkey-27c15.1 protein

Protein level used designations for NPR1

ANP-A , ANPR-A , GC-A , NPR-A , atrial natriuretic peptide receptor 1 , atrial natriuretic peptide receptor type A , atrionatriuretic peptide receptor A , guanylate cyclase A , natriuretic peptide A type receptor , natriuretic peptide receptor A , atrial natriuretic peptide A-type receptor , atrial natriuretic peptide receptor A , natriuretic peptide receptor 1 , aatriuretic peptide receptor A , guanylyl cyclase beta 1, soluable , natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) , Nppa receptor , guanylyl cyclase-A

GENE ID SPECIES
4881 Homo sapiens
24603 Rattus norvegicus
560653 Danio rerio
100343663 Oryctolagus cuniculus
18160 Mus musculus
842733 Arabidopsis thaliana
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