anti-Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) Antibodies

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). Additionally we are shipping NPR1 Kits (18) and NPR1 Proteins (18) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NPR1 4881 P16066
NPR1 24603 P18910
NPR1 18160 P18293
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Top anti-NPR1 Antibodies at antibodies-online.com

Showing 10 out of 88 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p) Immunofluorescence confocal photomicrograph of vertical sections of the rat retina, stained with anti-ANPA (NPR-A), ABIN392702. IF data courtesy of Dr. Essam Abdelalim, Shiga University of Medical Science. IF Immunostaining with anti-ANP and anti-human lamin antibodies revealed the presence of lamin-positive human ES cell derived-cardiomyocytes (Fig. 4A). (Stem Cells 2007 Sep 01.25(9):2200-2205) 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IF 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB Immunohistochemistry-Paraffin: NPR-1/Natriuretic Peptide Receptor A Antibody [NBP1-31333] - HBL435 xenograft. Immunohistochemistry-Paraffin: NPR-1/Natriuretic Peptide Receptor A Antibody [NBP1-31333] - Rat hind brain. 100 μL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$588.50
Details
Mouse Rabbit Un-conjugated IHC (p), WB Mouse Npr1 Antibody (N-term) (ABIN657994) western blot analysis in mouse heart tissue lysates (35 µg/lane). This demonstrates the Npr1 antibody detected the Npr1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western Blot: NPR-1/Natriuretic Peptide Receptor A Antibody [NBP1-32889] - Sample (30 ug of whole cell lysate) A: Hela 7.5% SDS PAGE; antibody diluted at 1:1000. Western Blot: NPR-1/Natriuretic Peptide Receptor A Antibody [NBP1-32889] - HeLa whole cell lysate using NBP1-32889. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Mouse Un-conjugated WB Western Blot: NPR-1/Natriuretic Peptide Receptor A Antibody (7H7) [NBP2-46202] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NPR-1. 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Cy5.5 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

NPR1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-NPR1 Antibodies

  1. Human Polyclonal NPR1 Primary Antibody for IHC (p) - ABIN392702 : Takahashi, Nakayama, Soma, Izumi, Kanmatsuse: Organization of the human natriuretic peptide receptor A gene. in Biochemical and biophysical research communications 1998 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal NPR1 Primary Antibody for ICC, IF - ABIN441340 : Kovacova, Tharp, Liu, Wei, Xie, Collins, Pratley: Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes. in Obesity (Silver Spring, Md.) 2016 (PubMed)

More Antibodies against NPR1 Interaction Partners

Human Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

  1. Data suggest that signaling via ANP (show NPPA Antibodies)/ANPR (atrial natriuretic factor/ANP (show NPPA Antibodies) receptor (show PPP5C Antibodies)) in vascular endothelial cells activates PAK4 (p21-activated kinase 4 (show PAK4 Antibodies)) and CCM2 (cerebral cavernous malformation 2 (show CCM2 Antibodies) protein), resulting in phosphorylation of MLC (myosin light chain), cytoskeletal reorganization, and cell spreading; kinase homology domain of ANPRA (guanylyl cyclase-A) activates downstream targets of ANP (show NPPA Antibodies)/ANPR signaling.

  2. After ligand binding, NPRA is rapidly internalized and trafficked from the cell surface into endosomes, Res and lysosomes, with concurrent generation of intracellular cyclic GMP (show NT5C2 Antibodies) in HEK (show EPHA3 Antibodies)-293 cells.

  3. Data suggest up-regulation of NPRA in skeletal muscle (SM) correlates with whole-body insulin sensitiv (show INS Antibodies)ity; NPRA is down-regulated in SM in obese subjects compared to normal controls; NPRA in SM is up-regulated in response to diet-induced weight loss.

  4. In this review we highlight the mechanisms by which NPR-A affects signaling pathways involved in inflammation and cancer, and we discuss its potential as a novel target in inflammation, cancer, and cancer-related inflammation

  5. NPRA was detected in E11.5 cardiac progenitor cells.

  6. Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A/-B activator.

  7. High NPR1 expression is associated with esophageal squamous cell carcinomas.

  8. Molecular dynamics analysis indicated decreases in the values of Van (show TNIP1 Antibodies) der (show GDF3 Antibodies) Waals, electrostatic energy and potential energy of NPRB (show NPR2 Antibodies)/Vasonatrin peptide compared to NPRA/Vasonatrin peptide.

  9. ACNP stimulated both human natriuretic peptide receptors (NPRs), NPRA and NPRB (show NPR2 Antibodies), as potent as their native ligands in receptor transfected cells.

  10. human ventricular cardiomyocytes express low levels of GC-A and GC-A in cardiomyocytes from failing human hearts is refractory to ANP (show NPPA Antibodies) stimulation.

Mouse (Murine) Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

  1. Treatment of the haplotype Npr1(+/-) mice with histone deacetylase (show HDAC1 Antibodies) inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1 (show HDAC1 Antibodies)/2, NF-kappaB (show NFKB1 Antibodies) (p65 (show NFkBP65 Antibodies)), and STAT1 (show STAT1 Antibodies).

  2. Data suggest that the negative inhibition of P2X3R activity by the BNP (show BNC2 Antibodies)/NPR-A pathway results in a decreased P2X3R-mediated excitability of trigeminal neurons in wildetype cultures. In familial hemiplegic migraine type-1 model cultures, however, lack of efficient P2X3Rs downregulation contributes to the neuronal hyperexcitability phenotype.

  3. The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis.

  4. Conclude that postnatal cardiac hyperplasia in mice with global GC-A (show GUCA1A Antibodies) inactivation is provoked by systemic alterations rather than direct regulation of cardiac myocyte proliferation.

  5. Data (including data from studies in knockout mice) suggest expression of ANP (show NPPA Antibodies)/BNP (show BNC2 Antibodies)/GC-A (show GUCA1A Antibodies) (atrial natriuretic peptide (show NPPA Antibodies), brain natriuretic peptide (show BNP Antibodies), and guanylyl cyclase-A) is important in embryonic neovascularization and organogenesis.

  6. Suggest that the FQQI motif is essential for the internalization and subcellular trafficking of NPRA during the hormone signaling process in intact mesangial cells.

  7. Data suggest activation of skeletal muscle (SM) Npra is important for maintenance of long-term insulin (show INS Antibodies) sensitivity; up-regulation of Npra signal transduction in SM (that was reduced by obesity) prevents glucose intolerance and diabetes type 2.

  8. these findings define a novel epigenetic regulatory mechanism that governs Npr1 gene transcription.

  9. Npr1 represses the expression of cardiac proinflammatory mediators, hypertrophic markers, and NF-kappaB/AP-1-mediated mechanisms, which seem to be associated in an Npr1 gene-dose-dependent manner

  10. ANP (show NPPA Antibodies) is capable of attenuating agonist-induced lung edema in the absence of NPR-A.

Arabidopsis thaliana Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

  1. We identified a rice mutant in the Kitaake genetic background with a frameshift mutation in crk10; this mutant also displays a compromised immune response highlighting the important role of crk10. We also show that elevated levels of NH1 expression lead to enhanced CRK10 expression and that the rice TGA2.1 protein binds to the CRK10 promoter.

  2. Green tissue-specific expression of Arabidopsis thaliana NPR1 is an effective strategy for controlling the sheath blight pathogen (Rhizoctonia solani) in rice. The present work in rice can be extended to other crop plants severely damaged by the pathogen.

  3. The results revealed a tight correlation between sequential salicylic acid (SA) and sic acid (ABA) signaling and dynamic changes in NPR1 protein levels and NPR1-dependent transcription in plant immune responses.

  4. Crosstalk between nitric oxide and glutathione is integral to the NPR1-dependent defense signaling pathway.

  5. The authors show that sumoylation of NPR1 by SUMO3 (show SUMO3 Antibodies) activates defense gene expression by switching NPR1's association with the WRKY transcription repressors to TGA (show TBX1 Antibodies) transcription activators.

  6. Altogether, our results indicate that AR156 can induce SAR by the SA-signaling pathways in an NPR1-dependent manner and involves multiple PTI components.

  7. NPR1-dependent salicylic acid signaling is not involved in the elevated carbon dioxide-induced heat shock tolerance.

  8. NPR1-dependent salicylic acid (SA) signalling is central to the salt and oxidative stress tolerance in Arabidopsis.

  9. MPK6-mediated WRKY6 and Trx h5 transcriptional activation co-regulated the expression of the NPR1 gene and the monomerization of NPR1 protein, allowing it to enter the nucleus, thereby promoting salicylic acid-induced leaf senescence.

  10. AtNPR1, AtGA2, and AtPR-5, encoding specific components involved in salicylic acid regulation, synthesis, and signaling, are overexpressed in soybean roots, resistance to soybean cyst nematode is enhanced.

NPR1 Antigen Profile

Protein Summary

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994

Gene names and symbols associated with NPR1

  • natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1) antibody
  • natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (Npr1) antibody
  • natriuretic peptide receptor 1a (npr1a) antibody
  • natriuretic peptide receptor 1 (Npr1) antibody
  • Regulatory protein NPR1 (NPR1) antibody
  • AI893888 antibody
  • ANPa antibody
  • Anpra antibody
  • ARABIDOPSIS NONEXPRESSER OF PR GENES 1 antibody
  • ATNPR1 antibody
  • F15H21.6 antibody
  • F15H21_6 antibody
  • GC-A antibody
  • Gca antibody
  • GUC2A antibody
  • GUCY2A antibody
  • NIM1 antibody
  • NON-INDUCIBLE IMMUNITY 1 antibody
  • NONEXPRESSER OF PR GENES 1 antibody
  • NPR-A antibody
  • Npra antibody
  • Pndr antibody
  • REGULATORY PROTEIN NPR1 antibody
  • SAI1 antibody
  • SALICYLIC ACID INSENSITIVE 1 antibody
  • sGC antibody
  • si:dkey-27c15.1 antibody

Protein level used designations for NPR1

ANP-A , ANPR-A , GC-A , NPR-A , atrial natriuretic peptide receptor 1 , atrial natriuretic peptide receptor type A , atrionatriuretic peptide receptor A , guanylate cyclase A , natriuretic peptide A type receptor , natriuretic peptide receptor A , atrial natriuretic peptide A-type receptor , atrial natriuretic peptide receptor A , natriuretic peptide receptor 1 , aatriuretic peptide receptor A , guanylyl cyclase beta 1, soluable , natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) , Nppa receptor , guanylyl cyclase-A

GENE ID SPECIES
4881 Homo sapiens
24603 Rattus norvegicus
560653 Danio rerio
100343663 Oryctolagus cuniculus
18160 Mus musculus
842733 Arabidopsis thaliana
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