Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) Proteins (NPR1)

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). Additionally we are shipping NPR1 Antibodies (88) and NPR1 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NPR1 4881 P16066
NPR1 24603 P18910
NPR1 18160 P18293
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Top NPR1 Proteins at antibodies-online.com

Showing 8 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,234.00
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Yeast Human His tag   50 μg Log in to see 8 to 11 Days
$341.00
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HOST_Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Log in to see 11 Days
$341.00
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HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details

NPR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , , ,
Rat (Rattus)

Mouse (Murine)
,

More Proteins for Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) Interaction Partners

Mouse (Murine) Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

  1. Data suggest that the negative inhibition of P2X3R activity by the BNP/NPR-A pathway results in a decreased P2X3R-mediated excitability of trigeminal neurons in wildetype cultures. In familial hemiplegic migraine type-1 model cultures, however, lack of efficient P2X3Rs downregulation contributes to the neuronal hyperexcitability phenotype.

  2. The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis.

  3. Conclude that postnatal cardiac hyperplasia in mice with global GC-A (show GUCA1A Proteins) inactivation is provoked by systemic alterations rather than direct regulation of cardiac myocyte proliferation.

  4. Data (including data from studies in knockout mice) suggest expression of ANP (show NPPA Proteins)/BNP/GC-A (show GUCA1A Proteins) (atrial natriuretic peptide (show NPPA Proteins), brain natriuretic peptide (show BNP Proteins), and guanylyl cyclase-A) is important in embryonic neovascularization and organogenesis.

  5. Suggest that the FQQI motif is essential for the internalization and subcellular trafficking of NPRA during the hormone signaling process in intact mesangial cells.

  6. Data suggest activation of skeletal muscle (SM) Npra is important for maintenance of long-ter (show INS Proteins)m insulin sensitivity; up-regulation of Npra signal transduction in SM (that was reduced by obesity) prevents glucose intolerance and diabetes type 2.

  7. these findings define a novel epigenetic regulatory mechanism that governs Npr1 gene transcription.

  8. Npr1 represses the expression of cardiac proinflammatory mediators, hypertrophic markers, and NF-kappaB/AP-1-mediated mechanisms, which seem to be associated in an Npr1 gene-dose-dependent manner

  9. ANP (show NPPA Proteins) is capable of attenuating agonist-induced lung edema in the absence of NPR-A.

  10. These results demonstrate that a high-salt diet aggravates cardiac ANG II, aldosterone and pro-inflammatory cytokine levels in Npr1 gene-disrupted 1-copy mice, whereas, in Npr1 gene-duplicated (3-copy and 4-copy) mice, high salt did not render such elevation, suggesting the potential roles of Npr1 against salt loading.

Human Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

  1. Data suggest that signaling via ANP (show NPPA Proteins)/ANPR (atrial natriuretic factor/ANP (show NPPA Proteins) receptor (show PPP5C Proteins)) in vascular endothelial cells activates PAK4 (p21-activated kinase 4 (show PAK4 Proteins)) and CCM2 (cerebral cavernous malformation 2 (show CCM2 Proteins) protein), resulting in phosphorylation of MLC (myosin light chain), cytoskeletal reorganization, and cell spreading; kinase homology domain of ANPRA (guanylyl cyclase-A) activates downstream targets of ANP (show NPPA Proteins)/ANPR signaling.

  2. After ligand binding, NPRA is rapidly internalized and trafficked from the cell surface into endosomes, Res and lysosomes, with concurrent generation of intracellular cyclic GMP (show NT5C2 Proteins) in HEK (show EPHA3 Proteins)-293 cells.

  3. Data suggest up-regulation of NPRA in skeletal muscle (SM) correlates with whole-body insulin (show INS Proteins) sensitivity; NPRA is down-regulated in SM in obese subjects compared to normal controls; NPRA in SM is up-regulated in response to diet-induced weight loss.

  4. In this review we highlight the mechanisms by which NPR-A affects signaling pathways involved in inflammation and cancer, and we discuss its potential as a novel target in inflammation, cancer, and cancer-related inflammation

  5. NPRA was detected in E11.5 cardiac progenitor cells.

  6. Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A/-B activator.

  7. High NPR1 expression is associated with esophageal squamous cell carcinomas.

  8. Molecular dynamics analysis indicated decreases in the values of Van (show TNIP1 Proteins) der (show GDF3 Proteins) Waals, electrostatic energy and potential energy of NPRB (show NPR2 Proteins)/Vasonatrin peptide compared to NPRA/Vasonatrin peptide.

  9. ACNP stimulated both human natriuretic peptide receptors (NPRs), NPRA and NPRB (show NPR2 Proteins), as potent as their native ligands in receptor transfected cells.

  10. human ventricular cardiomyocytes express low levels of GC-A and GC-A in cardiomyocytes from failing human hearts is refractory to ANP (show NPPA Proteins) stimulation.

NPR1 Protein Profile

Protein Summary

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994

Gene names and symbols associated with NPR1

  • natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1)
  • natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (Npr1)
  • natriuretic peptide receptor 1a (npr1a)
  • natriuretic peptide receptor 1 (Npr1)
  • Regulatory protein NPR1 (NPR1)
  • AI893888 protein
  • ANPa protein
  • Anpra protein
  • ARABIDOPSIS NONEXPRESSER OF PR GENES 1 protein
  • ATNPR1 protein
  • F15H21.6 protein
  • F15H21_6 protein
  • GC-A protein
  • Gca protein
  • GUC2A protein
  • GUCY2A protein
  • NIM1 protein
  • NON-INDUCIBLE IMMUNITY 1 protein
  • NONEXPRESSER OF PR GENES 1 protein
  • NPR-A protein
  • Npra protein
  • Pndr protein
  • REGULATORY PROTEIN NPR1 protein
  • SAI1 protein
  • SALICYLIC ACID INSENSITIVE 1 protein
  • sGC protein
  • si:dkey-27c15.1 protein

Protein level used designations for NPR1

ANP-A , ANPR-A , GC-A , NPR-A , atrial natriuretic peptide receptor 1 , atrial natriuretic peptide receptor type A , atrionatriuretic peptide receptor A , guanylate cyclase A , natriuretic peptide A type receptor , natriuretic peptide receptor A , atrial natriuretic peptide A-type receptor , atrial natriuretic peptide receptor A , natriuretic peptide receptor 1 , aatriuretic peptide receptor A , guanylyl cyclase beta 1, soluable , natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) , Nppa receptor , guanylyl cyclase-A

GENE ID SPECIES
4881 Homo sapiens
24603 Rattus norvegicus
560653 Danio rerio
100343663 Oryctolagus cuniculus
18160 Mus musculus
842733 Arabidopsis thaliana
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