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anti-Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) Antibodies

NPR2 encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Additionally we are shipping NPR2 Proteins (20) and NPR2 Kits (16) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NPR2 230103 Q6VVW5
NPR2 4882 P20594
NPR2 116564 P16067
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Top anti-NPR2 Antibodies at antibodies-online.com

Showing 10 out of 83 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-NPRB/Natriuretic Peptide Receptor B Polyclonal Antibody, Unconjugated (ABIN679778) at 1:200 followed by conjugation to the secondary antibody 100 μL Log in to see 3 to 7 Days
$269.50
Details
Mouse Rabbit Un-conjugated WB Mouse Npr2 Antibody (Center) (ABIN658174) western blot analysis in mouse heart tissue lysates (35 µg/lane). This demonstrates the Npr2 antibody detected the Npr2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (fro), WB 0.1 mL Log in to see 6 to 8 Days
$588.50
Details
Human Rabbit Un-conjugated IHC (p) 7 mL Log in to see 21 to 31 Days
$226.00
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Rabbit Un-conjugated WB   0.1 mL Log in to see 6 to 8 Days
$588.50
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$511.50
Details
Mouse Rabbit Biotin ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

NPR2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-NPR2 Antibodies

  1. Human Polyclonal NPR2 Primary Antibody for WB - ABIN191700 : Küthe, Reinecke, Uckert, Becker, David, Heitland, Stief, Forssmann, Mägert: Expression of guanylyl cyclase B in the human corpus cavernosum penis and the possible involvement of its ligand C-type natriuretic polypeptide in the induction of penile erection. in The Journal of urology 2003 (PubMed)

  2. Human Polyclonal NPR2 Primary Antibody for IF (p), IHC (p) - ABIN679778 : Li, Tang, Cai, Qiu, Lin, Zhu, Owusu, Guo: CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan. in World journal of gastroenterology : WJG 2015 (PubMed)

  3. Human Polyclonal NPR2 Primary Antibody for IHC (fro), WB - ABIN191698 : Hirsch, Skutta, Schlatter: Signaling and distribution of NPR-Bi, the human splice form of the natriuretic peptide receptor type B. in American journal of physiology. Renal physiology 2003 (PubMed)

More Antibodies against NPR2 Interaction Partners

Mouse (Murine) Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) interaction partners

  1. NPR2 (show NPRL2 Antibodies) is involved in FSH (show BRD2 Antibodies)-mediated oocyte meiotic resumption, and this process is associated with the EGFR (show EGFR Antibodies) and MAPK3 (show MAPK3 Antibodies)/1 signaling pathways.

  2. NPR2 (show NPRL2 Antibodies) dephosphorylation in the mural granulosa cells is essential for the normal progression of meiosis in response to LH and EGF receptor (show EGFR Antibodies) activation.

  3. Npr2 (show NPRL2 Antibodies) is necessary for the precise spatial organization typical of central auditory circuits, but signals are still transmitted with normal timing, and that mutant mice can hear even with these deficits.

  4. Npr2 (show NPRL2 Antibodies) is expressed in hard calluses of wild-type mice, suggesting a possible role of CNP (show CNP Antibodies) signaling in fracture repair, especially in bone remodeling stage.

  5. Data, including data from mutant mice strain Npr2 (show NPRL2 Antibodies)(slw/slw), suggest that Npr2 (show NPRL2 Antibodies) is critical for fertility but role of Npr2 (show NPRL2 Antibodies) may be more involved in penile function rather than involved in spermatogenesis.

  6. These findings demonstrate that pNPPB may be used as a probe to identify the essential amino acid sequences for activation of NPR2 (show NPRL2 Antibodies).

  7. GATA2 (show GATA2 Antibodies) and Lmo2 (show LMO2 Antibodies) cooperatively regulate VEGF (show VEGFA Antibodies)-induced angiogenesis and lymphangiogenesis via NRP2 (show NRP2 Antibodies).

  8. Data suggest that epidermal growth factor (Egf)/Egf (show EGF Antibodies) receptor (show EGFR Antibodies) signaling in cumulus cells (CC) down-regulates Npr2 (show NPRL2 Antibodies), decreases cGMP, elevates calcium, and induces meiotic resumption/oogenesis in cultured CC-oocyte complexes (in induced meiotic arrest).

  9. CNP (show CNP Antibodies)/NPR2 (show NPRL2 Antibodies) signaling is essential for oocyte meiotic arrest in early antral follicles and activated LH/amphiregulin (show AREG Antibodies)/EGFR (show EGFR Antibodies) signaling pathway suppresses this signal by downregulating Nppc (show NPPC Antibodies) expression.

  10. NPPC (show NPPC Antibodies)/NPR2 (show NPRL2 Antibodies) signaling is essential for oocyte meiotic arrest and cumulus oophorus formation, which affects female fertility through the production of oocytes with developmental capacity.

Human Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) interaction partners

  1. Loss-of-function mutations of the NPR2 (show NPRL2 Antibodies) gene is associated with acromesomelic dysplasia, type maroteaux.

  2. NPR2 (show NPRL2 Antibodies) mutations account for approximately 3% of patients with disproportionate short stature and/or clinical or radiographic indicators of SHOX (show SHOX Antibodies) deficiency and in whom no SHOX (show SHOX Antibodies) defect has been identified.

  3. 3 consanguineous families segregating Acromesomelic dysplasia Maroteaux type in an autosomal recessive manner studied. Linkage in the families was established to the NPR2 (show NPRL2 Antibodies) gene on chromosome 9p12-21. Sequence analysis revealed 2 novel missense variants (p.Arg601Ser; p.Arg749Trp) in 2 families and a previously reported splice site variant (c.2986+2T>G) in the third family.

  4. Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A (show NPR1 Antibodies)/-B activator.

  5. Gene expression of C-type natriuretic peptide (show NPPC Antibodies) and of its specific receptor NPR-B in human leukocytes of healthy and heart failure subjects

  6. Molecular dynamics analysis indicated decreases in the values of Van (show TNIP1 Antibodies) der (show GDF3 Antibodies) Waals, electrostatic energy and potential energy of NPRB/Vasonatrin peptide compared to NPRA (show NPR1 Antibodies)/Vasonatrin peptide.

  7. Identification of heterozygous dominant negative NPR2 (show NPRL2 Antibodies) mutations in 2% of Japanese patients with short stature.

  8. KIdney NPR2 (show NPRL2 Antibodies) protein quantity is significantly impacted by genetic variation.

  9. study concludes V883M mutation increases maximal velocity in absence of C-type natriuretic peptide (CNP (show NPPC Antibodies)), eliminates requirement for ATP in the CNP (show CNP Antibodies)-dependent Km reduction and disrupts normal inactivation process; established a molecular mechanism for how an amino acid substitution in GC-B activates the enzyme, which results in abnormally long and fragile bones

  10. In transgenic mice, complete absence of Npr2 (show NPRL2 Antibodies) activity prohibits the bifurcation of cranial sensory axons.

Cow (Bovine) Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) interaction partners

  1. These data support the existence of a novel transducing cascade, involving Galpha (show SUCLG1 Antibodies)(q16)beta gamma coupling M(3)AChR to NPR (show NPTXR Antibodies)-GC.

  2. NPR-B is a highly regulated nano-machinery with domains acting at cross-talk points with other signal transducing cascades initiated by G protein-coupled receptors

  3. ATP is not required for the initial activation of natriuretic peptide receptor A (show NPR1 Antibodies) and B, but does increase activity over time by reducing the apparent K(m) for GTP (show AK3 Antibodies).

NPR2 Antigen Profile

Protein Summary

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.

Gene names and symbols associated with NPR2

  • natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) (NPR2) antibody
  • natriuretic peptide receptor 2 (Npr2) antibody
  • natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) (Npr2) antibody
  • AMDM antibody
  • ANPb antibody
  • ANPRB antibody
  • cn antibody
  • GC-B antibody
  • GC-B2 antibody
  • GC-B3 antibody
  • GUC2B antibody
  • GUCY2B antibody
  • mNPR-B antibody
  • NPR-B antibody
  • NPR2 antibody
  • NPRB antibody
  • NPRBi antibody
  • pwe antibody

Protein level used designations for NPR2

natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) , natriuretic peptide receptor 2 , ANP-B , ANPR-B , NPR-B , Nppb receptor , atrial natriuretic peptide receptor 2 , atrial natriuretic peptide receptor type B , guanylate cyclase B , guanylyl cyclase-B , natriuretic peptide receptor B type , GC-B , atrial natriuretic peptide B-type receptor , ANPRB , atrial natriuretic peptide receptor B , natriuretic peptide receptor-B , atrionatriuretic peptide receptor B

GENE ID SPECIES
692193 Sus scrofa
230103 Mus musculus
4882 Homo sapiens
116564 Rattus norvegicus
281357 Bos taurus
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