You are viewing an incomplete version of our website. Please click to reload the website as full version.

Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) Proteins (NPR2)

NPR2 encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Additionally we are shipping NPR2 Antibodies (83) and NPR2 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NPR2 230103 Q6VVW5
NPR2 4882 P20594
NPR2 116564 P16067
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top NPR2 Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Mammalian Cells Human His tag 100 μg Log in to see 13 to 16 Days
$1,490.50
Details
HOST_Escherichia coli (E. coli) Mouse GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Mouse His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

NPR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
, ,
Human , , , , , ,
, , ,
Rat (Rattus)

More Proteins for Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) Interaction Partners

Mouse (Murine) Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) interaction partners

  1. NPR2 (show NPRL2 Proteins) is involved in FSH (show BRD2 Proteins)-mediated oocyte meiotic resumption, and this process is associated with the EGFR (show EGFR Proteins) and MAPK3 (show MAPK3 Proteins)/1 signaling pathways.

  2. NPR2 (show NPRL2 Proteins) dephosphorylation in the mural granulosa cells is essential for the normal progression of meiosis in response to LH and EGF receptor (show EGFR Proteins) activation.

  3. Npr2 (show NPRL2 Proteins) is necessary for the precise spatial organization typical of central auditory circuits, but signals are still transmitted with normal timing, and that mutant mice can hear even with these deficits.

  4. Npr2 (show NPRL2 Proteins) is expressed in hard calluses of wild-type mice, suggesting a possible role of CNP (show CNP Proteins) signaling in fracture repair, especially in bone remodeling stage.

  5. Data, including data from mutant mice strain Npr2 (show NPRL2 Proteins)(slw/slw), suggest that Npr2 (show NPRL2 Proteins) is critical for fertility but role of Npr2 (show NPRL2 Proteins) may be more involved in penile function rather than involved in spermatogenesis.

  6. These findings demonstrate that pNPPB may be used as a probe to identify the essential amino acid sequences for activation of NPR2 (show NPRL2 Proteins).

  7. GATA2 (show GATA2 Proteins) and Lmo2 (show LMO2 Proteins) cooperatively regulate VEGF (show VEGFA Proteins)-induced angiogenesis and lymphangiogenesis via NRP2 (show NRP2 Proteins).

  8. Data suggest that epidermal growth factor (Egf)/Egf (show EGF Proteins) receptor (show EGFR Proteins) signaling in cumulus cells (CC) down-regulates Npr2 (show NPRL2 Proteins), decreases cGMP, elevates calcium, and induces meiotic resumption/oogenesis in cultured CC-oocyte complexes (in induced meiotic arrest).

  9. CNP (show CNP Proteins)/NPR2 (show NPRL2 Proteins) signaling is essential for oocyte meiotic arrest in early antral follicles and activated LH/amphiregulin (show AREG Proteins)/EGFR (show EGFR Proteins) signaling pathway suppresses this signal by downregulating Nppc (show NPPC Proteins) expression.

  10. NPPC (show NPPC Proteins)/NPR2 (show NPRL2 Proteins) signaling is essential for oocyte meiotic arrest and cumulus oophorus formation, which affects female fertility through the production of oocytes with developmental capacity.

Human Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) interaction partners

  1. Loss-of-function mutations of the NPR2 (show NPRL2 Proteins) gene is associated with acromesomelic dysplasia, type maroteaux.

  2. NPR2 (show NPRL2 Proteins) mutations account for approximately 3% of patients with disproportionate short stature and/or clinical or radiographic indicators of SHOX (show SHOX Proteins) deficiency and in whom no SHOX (show SHOX Proteins) defect has been identified.

  3. 3 consanguineous families segregating Acromesomelic dysplasia Maroteaux type in an autosomal recessive manner studied. Linkage in the families was established to the NPR2 (show NPRL2 Proteins) gene on chromosome 9p12-21. Sequence analysis revealed 2 novel missense variants (p.Arg601Ser; p.Arg749Trp) in 2 families and a previously reported splice site variant (c.2986+2T>G) in the third family.

  4. Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A (show NPR1 Proteins)/-B activator.

  5. Gene expression of C-type natriuretic peptide (show NPPC Proteins) and of its specific receptor NPR-B in human leukocytes of healthy and heart failure subjects

  6. Molecular dynamics analysis indicated decreases in the values of Van (show TNIP1 Proteins) der (show GDF3 Proteins) Waals, electrostatic energy and potential energy of NPRB/Vasonatrin peptide compared to NPRA (show NPR1 Proteins)/Vasonatrin peptide.

  7. Identification of heterozygous dominant negative NPR2 (show NPRL2 Proteins) mutations in 2% of Japanese patients with short stature.

  8. KIdney NPR2 (show NPRL2 Proteins) protein quantity is significantly impacted by genetic variation.

  9. study concludes V883M mutation increases maximal velocity in absence of C-type natriuretic peptide (CNP (show NPPC Proteins)), eliminates requirement for ATP in the CNP (show CNP Proteins)-dependent Km reduction and disrupts normal inactivation process; established a molecular mechanism for how an amino acid substitution in GC-B activates the enzyme, which results in abnormally long and fragile bones

  10. In transgenic mice, complete absence of Npr2 (show NPRL2 Proteins) activity prohibits the bifurcation of cranial sensory axons.

Cow (Bovine) Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) interaction partners

  1. These data support the existence of a novel transducing cascade, involving Galpha (show SUCLG1 Proteins)(q16)beta gamma coupling M(3)AChR to NPR (show NPTXR Proteins)-GC.

  2. NPR-B is a highly regulated nano-machinery with domains acting at cross-talk points with other signal transducing cascades initiated by G protein-coupled receptors

  3. ATP is not required for the initial activation of natriuretic peptide receptor A (show NPR1 Proteins) and B, but does increase activity over time by reducing the apparent K(m) for GTP (show AK3 Proteins).

NPR2 Protein Profile

Protein Summary

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.

Gene names and symbols associated with NPR2

  • natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) (NPR2)
  • natriuretic peptide receptor 2 (Npr2)
  • natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) (Npr2)
  • AMDM protein
  • ANPb protein
  • ANPRB protein
  • cn protein
  • GC-B protein
  • GC-B2 protein
  • GC-B3 protein
  • GUC2B protein
  • GUCY2B protein
  • mNPR-B protein
  • NPR-B protein
  • NPR2 protein
  • NPRB protein
  • NPRBi protein
  • pwe protein

Protein level used designations for NPR2

natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) , natriuretic peptide receptor 2 , ANP-B , ANPR-B , NPR-B , Nppb receptor , atrial natriuretic peptide receptor 2 , atrial natriuretic peptide receptor type B , guanylate cyclase B , guanylyl cyclase-B , natriuretic peptide receptor B type , GC-B , atrial natriuretic peptide B-type receptor , ANPRB , atrial natriuretic peptide receptor B , natriuretic peptide receptor-B , atrionatriuretic peptide receptor B

GENE ID SPECIES
692193 Sus scrofa
230103 Mus musculus
4882 Homo sapiens
116564 Rattus norvegicus
281357 Bos taurus
Selected quality suppliers for NPR2 Proteins (NPR2)
Did you look for something else?