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Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. Additionally we are shipping NDFIP2 Proteins (3) and many more products for this protein.
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Mouse (Murine) Polyclonal NDFIP2 Primary Antibody for IHC, WB - ABIN350511
Carninci, Kasukawa, Katayama, Gough, Frith, Maeda, Oyama, Ravasi, Lenhard, Wells, Kodzius, Shimokawa, Bajic, Brenner, Batalov, Forrest, Zavolan, Davis, Wilming, Aidinis, Allen, Ambesi-Impiombato et al.: The transcriptional landscape of the mammalian genome. ... in Science (New York, N.Y.) 2005
Show all 3 references for ABIN350511
Rat (Rattus) Polyclonal NDFIP2 Primary Antibody for WB - ABIN610876
Jones, Jakubowicz, Pitossi, Maurer, Hemmings: Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. in Proceedings of the National Academy of Sciences of the United States of America 1991
Show all 2 references for ABIN610876
Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi.
PTEN (show PTEN Antibodies)/Akt (show AKT1 Antibodies) and MAP kinase (show MAPK1 Antibodies) signaling pathways are regulated by the ubiquitin ligase activators Ndfip1 (show NDFIP1 Antibodies) and Ndfip2
N4WBP5A may play a regulatory role in modulating Nedd4 activity at the level of the Golgi apparatus in T lymphocytes
N4WBP5A acts as an adaptor to recruit Nedd4 family ubiquitin-protein ligases to the protein trafficking machinery
Data show that the small PY-containing membrane proteins, NDFIP1 and NDFIP2 (NEDD4 family-interacting proteins), activate the catalytic activity of ITCH and of several other HECT ligases by binding to them.
Data indicate thar Janus kinase 1 (Jak1 (show JAK1 Antibodies)) degradation is dependent on Nedd4 family interacting proteins Ndfip1 (show NDFIP1 Antibodies)/Ndfip2.
DMT1 (show SLC11A2 Antibodies) interacts with 2 WW domain (show DRP2 Antibodies)-interacting proteins, Ndfip1 (show NDFIP1 Antibodies) and Ndfip2. This promotes DMT1 (show SLC11A2 Antibodies) ubiquitination and degradation by WWP2 (show WWP2 Antibodies).
Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling.
Nedd4 family interacting protein 2
, NEDD4 family-interacting protein 2
, MAPK-activating protein PM04 PM05 PM06 PM07
, NEDD4 WW domain-binding protein 5A
, NF-kappa-B-activating protein 413
, putative MAPK-activating protein PM04/PM05/PM06/PM07
, putative NF-kappa-B-activating protein 413