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Nedd4 Family Interacting Protein 2 Proteins (NDFIP2)

Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. Additionally we are shipping NDFIP2 Antibodies (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NDFIP2 54602 Q9NV92
Mouse NDFIP2 NDFIP2 76273  
Rat NDFIP2 NDFIP2 361089  
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Top NDFIP2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

NDFIP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Nedd4 Family Interacting Protein 2 (NDFIP2) Interaction Partners

Human Nedd4 Family Interacting Protein 2 (NDFIP2) interaction partners

  1. Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi.

  2. PTEN/Akt (show AKT1 Proteins) and MAP kinase (show MAPK1 Proteins) signaling pathways are regulated by the ubiquitin ligase activators Ndfip1 (show NDFIP1 Proteins) and Ndfip2

  3. N4WBP5A may play a regulatory role in modulating Nedd4 activity at the level of the Golgi apparatus in T lymphocytes

  4. N4WBP5A acts as an adaptor to recruit Nedd4 family ubiquitin-protein ligases to the protein trafficking machinery

  5. Data show that the small PY-containing membrane proteins, NDFIP1 and NDFIP2 (NEDD4 family-interacting proteins), activate the catalytic activity of ITCH and of several other HECT ligases by binding to them.

Mouse (Murine) Nedd4 Family Interacting Protein 2 (NDFIP2) interaction partners

  1. Data indicate thar Janus kinase 1 (Jak1 (show JAK1 Proteins)) degradation is dependent on Nedd4 family interacting proteins Ndfip1 (show NDFIP1 Proteins)/Ndfip2.

  2. DMT1 (show SLC11A2 Proteins) interacts with 2 WW domain-interacting proteins, Ndfip1 (show NDFIP1 Proteins) and Ndfip2. This promotes DMT1 (show SLC11A2 Proteins) ubiquitination and degradation by WWP2 (show WWP2 Proteins).

NDFIP2 Protein Profile

Protein Summary

Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling.

Gene names and symbols associated with NDFIP2

  • Nedd4 family interacting protein 2 (ndfip2)
  • Nedd4 family interacting protein 2 (NDFIP2)
  • Nedd4 family interacting protein 2 (Ndfip2)
  • 0710001O20Rik protein
  • 2810436B12Rik protein
  • 9130207N19Rik protein
  • DKFZp459H0627 protein
  • MGC68708 protein
  • mKIAA1165 protein
  • N4wbp5a protein

Protein level used designations for NDFIP2

Nedd4 family interacting protein 2 , NEDD4 family-interacting protein 2 , MAPK-activating protein PM04 PM05 PM06 PM07 , NEDD4 WW domain-binding protein 5A , NF-kappa-B-activating protein 413 , putative MAPK-activating protein PM04/PM05/PM06/PM07 , putative NF-kappa-B-activating protein 413

GENE ID SPECIES
398794 Xenopus laevis
418803 Gallus gallus
467290 Pan troglodytes
476956 Canis lupus familiaris
512310 Bos taurus
549748 Xenopus (Silurana) tropicalis
698464 Macaca mulatta
100173219 Pongo abelii
54602 Homo sapiens
76273 Mus musculus
361089 Rattus norvegicus
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