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Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. Additionally we are shipping NDFIP2 Antibodies (10) and many more products for this protein.
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Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi.
PTEN/Akt (show AKT1 Proteins) and MAP kinase (show MAPK1 Proteins) signaling pathways are regulated by the ubiquitin ligase activators Ndfip1 (show NDFIP1 Proteins) and Ndfip2
N4WBP5A may play a regulatory role in modulating Nedd4 activity at the level of the Golgi apparatus in T lymphocytes
N4WBP5A acts as an adaptor to recruit Nedd4 family ubiquitin-protein ligases to the protein trafficking machinery
Data show that the small PY-containing membrane proteins, NDFIP1 and NDFIP2 (NEDD4 family-interacting proteins), activate the catalytic activity of ITCH and of several other HECT ligases by binding to them.
Data indicate thar Janus kinase 1 (Jak1 (show JAK1 Proteins)) degradation is dependent on Nedd4 family interacting proteins Ndfip1 (show NDFIP1 Proteins)/Ndfip2.
DMT1 (show SLC11A2 Proteins) interacts with 2 WW domain-interacting proteins, Ndfip1 (show NDFIP1 Proteins) and Ndfip2. This promotes DMT1 (show SLC11A2 Proteins) ubiquitination and degradation by WWP2 (show WWP2 Proteins).
Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling.
Nedd4 family interacting protein 2
, NEDD4 family-interacting protein 2
, MAPK-activating protein PM04 PM05 PM06 PM07
, NEDD4 WW domain-binding protein 5A
, NF-kappa-B-activating protein 413
, putative MAPK-activating protein PM04/PM05/PM06/PM07
, putative NF-kappa-B-activating protein 413