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anti-Nemo-Like Kinase (NLK) Antibodies

Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Additionally we are shipping Nemo-Like Kinase Proteins (8) and Nemo-Like Kinase Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NLK 14751 P06745
NLK 292804 Q6P6V0
NLK 51701 Q9UBE8
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Top anti-Nemo-Like Kinase Antibodies at antibodies-online.com

Showing 10 out of 104 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IF, WB NLK-T286 (ABIN652357) western blot analysis in Y79 cell line lysates (35 µg/lane).This demonstrates the NLK antibody detected the NLK protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Mouse Nlk Antibody (C-term) (ABIN657850) western blot analysis in mouse lung tissue lysates (35 µg/lane). This demonstrates the Nlk antibody detected the Nlk protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of anti-NLK Pab in A375 cell lysate. NLK (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-NLK Pab (ABIN391786) in A375 cell lysate. NLK (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-NLK Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: 293T cell lysate WB Suggested Anti-NLK  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control:.93T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated WB NLK Antibody (ABIN1882269) western blot analysis in SiHa,Hela cell line lysates (35 µg/lane). This demonstrates the NLK antibody detected the NLK protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (50 ug of whole cell lysate) A: Mouse brain 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image NLK antibody [N3C3] detects NLK protein at cytosol and nucleus on mouse ovary by immunohistochemical analysis. Sample: Paraffin-embedded mouse ovary. NLK antibody [N3C3] , dilution: 1:500. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated ICC, WB   100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details

NLK Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Nemo-Like Kinase Antibodies

  1. Human Polyclonal NLK Primary Antibody for EIA, IHC (p) - ABIN359699 : Yasuda, Tsuchiya, Yamada, Sakamoto, Sekiya, Hirohashi: Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells. in Biochemical and biophysical research communications 2003 (PubMed)
    Show all 5 references for ABIN359699

  2. Human Polyclonal NLK Primary Antibody for IHC (p), WB - ABIN391786 : Ishitani, Ninomiya-Tsuji, Matsumoto: Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. in Molecular and cellular biology 2003 (PubMed)
    Show all 5 references for ABIN391786

  3. Human Monoclonal NLK Primary Antibody for WB - ABIN1882269 : Ohkawara, Shirakabe, Hyodo-Miura, Matsuo, Ueno, Matsumoto, Shibuya: Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. in Genes & development 2004 (PubMed)
    Show all 4 references for ABIN1882269

  4. Human Polyclonal NLK Primary Antibody for FACS, IF - ABIN652357 : Kim, Kim, Lee, Chung: Regulation of FOXO1 by TAK1-Nemo-like kinase pathway. in The Journal of biological chemistry 2010 (PubMed)
    Show all 4 references for ABIN652357

  5. Human Polyclonal NLK Primary Antibody for IHC (p), WB - ABIN657850 : Li, Wang, Huang, Wang, Ding, Li, Zhang, Li: TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling. in The Journal of biological chemistry 2010 (PubMed)

More Antibodies against Nemo-Like Kinase Interaction Partners

Mouse (Murine) Nemo-Like Kinase (NLK) interaction partners

  1. NLK can phosphorylate the mutant polyglutamine-expanded androgen receptor (show AR Antibodies) protein, enhance its aggregation, and promote androgen receptor (show AR Antibodies)-dependent gene transcription by regulating androgen receptor (show AR Antibodies)-cofactor interactions.

  2. Nlk is a negative regulator of skeletal homeostasis.

  3. PGI (show BGN Antibodies) is a moonlighting protein that functions as a cytosolic enzyme involved in glycolysis and gluconeogenesis, and as cytokine through binding to its cell surface receptor.

  4. The mGPI-transgenic mice presented GPI (show GPI Antibodies) more efficiently and showed a dramatic increase in negative selection and an inhibition of arthritis.

  5. either reducing NLK enzymatic activity or decreasing NLK expression levels can have beneficial effects against the toxicity induced by polyglutamine-expanded ATXN1 (show ATXN1 Antibodies)

  6. Increased red cell turnover in a line of CD22 (show CD22 Antibodies)-deficient mice is caused by Gpi1c: a model for hereditary haemolytic anaemia.

  7. NEMO (show IKBKG Antibodies) binding domain peptide treatment results in improved generation of specific force and greater resistance to lengthening activations in dystrophic diaphragm muscle ex vivo.

  8. Nlk suppresses osteoblastogenesis by opposing BMP/Smad (show SMAD1 Antibodies) and WNT (show WNT2 Antibodies) canonical signaling

  9. Data show that silencing of AMF/PGI (show GPI Antibodies) induced MET and suppressed the tumor growth and pulmonary metastasis of LM8 cells in nude mice.

  10. Wnt3a (show WNT3A Antibodies) stimulation led to an increase in the interaction of TAB2 (show TAB2 Antibodies) with NLK and the formation of a TAK1 (show NR2C2 Antibodies).TAB2 (show TAB2 Antibodies).NLK complex, suggesting that this TAK1 (show NR2C2 Antibodies)-TAB2 (show TAB2 Antibodies)-NLK pathway may constitute a negative feedback mechanism for canonical Wnt (show WNT2 Antibodies) signaling.

Zebrafish Nemo-Like Kinase (NLK) interaction partners

  1. NLK negatively regulates Notch (show NOTCH1 Antibodies)-dependent transcriptional activation by phosphorylating Notch1ICD. Phosphorylated Notch1ICD is impaired in its ability to form a transcriptionally active ternary complex.

  2. nlk strongly enhances convergent/extension phenotypes, suggesting a role in modulating cell movements as well as cell fate.

Xenopus laevis Nemo-Like Kinase (NLK) interaction partners

  1. NLK1 acts as a kinase by catalyzing phosphorylation of pumilio (Pum)1, Pum2, and cytoplasmic polyadenylation element binding protein 1 (CPEB) to regulate translation of mRNAs, including cyclin B1 mRNA, stored in oocytes.

  2. These results provide the first evidence that p38 (show MAPK14 Antibodies) specifically regulates NLK function, which is required for anterior formation in Xenopus development.

Human Nemo-Like Kinase (NLK) interaction partners

  1. NLK overexpression is an independent prognostic factor in colorectal cancer and knockdown of NLK expression inhibits colorectal cancer progression and metastasis.

  2. Further experiments demonstrated that the overexpression of miR3623p resulted in decrease expression levels of nemo-like kinase

  3. NLK was involved in miR (show MLXIP Antibodies)-92b-induced cell proliferation, and its protein level was obviously downregulated in the miR (show MLXIP Antibodies)-92b-overexpressing xenograft tumors.

  4. Data show that metformin inhibits nemo like kinase (NLK) expression and might be a potential treatment strategy for non-small cell lung cancer (NSCLC).

  5. Down-regulation of NLK inhibited tumorigenesis and up-regulated the expression of cell cycle proteins in laryngeal cancer cells.

  6. In this review, we will make a summary on the comprehensive roles of NLK in the regulation of various cancers

  7. NLK was an identified miR (show MLXIP Antibodies)-199a-3p target gene and functioned as a tumor suppressor gene in colorectal cancer.

  8. NLK overexpression is associated with poor overall survival in patients with hepatocellular carcinoma(HCC (show FAM126A Antibodies)), it might be an independent poor prognostic marker for HCC (show FAM126A Antibodies).

  9. NLK phosphorylates Raptor (show RPTOR Antibodies) on S863 to disrupt its interaction with the Rag GTPase (show RACGAP1 Antibodies), which is important for mTORC1 lysosomal recruitment.

  10. our work first demonstrated that miR (show MLXIP Antibodies)-197 can confer drug resistance to Taxol, by regulating tumor suppressor, NLK expression in ovarian cancer cells.

Pig (Porcine) Nemo-Like Kinase (NLK) interaction partners

  1. These data show that porcine epidemic diarrhea virus nsp5 (show SPECC1 Antibodies) disrupts type I interferon (show IFNA Antibodies) signaling by cleaving NEMO (show IKBKG Antibodies).

Nemo-Like Kinase (NLK) Antigen Profile

Protein Summary

Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (By similarity).

Gene names and symbols associated with anti-Nemo-Like Kinase (NLK) Antibodies

  • glucose phosphate isomerase 1 (Gpi1) antibody
  • nemo-like kinase (NLK) antibody
  • nemo like kinase, type 1 (nlk1) antibody
  • nemo-like kinase (nlk) antibody
  • Nemo-like kinase (NLK) antibody
  • Nemo-Like kinase (nemo-like) antibody
  • glucose-6-phosphate isomerase (Gpi) antibody
  • nemo like kinase (Nlk) antibody
  • AI194375 antibody
  • Amf antibody
  • Gpi antibody
  • Gpi-1 antibody
  • Gpi-1r antibody
  • Gpi-1s antibody
  • Gpi-1t antibody
  • Gpi1 antibody
  • Gpi1-r antibody
  • Gpi1-s antibody
  • Gpi1-t antibody
  • Gpi1s antibody
  • MF antibody
  • nemo-like antibody
  • NK antibody
  • NK/GPI antibody
  • NLK antibody
  • nlk1 antibody
  • nlk2 antibody
  • nlkb antibody
  • Org antibody
  • RGD1561602 antibody
  • Xnlk antibody
  • zgc:111875 antibody

Protein level used designations for anti-Nemo-Like Kinase (NLK) Antibodies

NLK , PGI , PHI , autocrine motility factor , glucose phosphate isomerase 1 complex , glucose phosphate isomerase 1, regulatory , glucose phosphate isomerase 1, structural , glucose phosphate isomerase 1, temporal , glucose-6-phosphate isomerase , maturation factor , neuroleukin , phosphoglucose isomerase , phosphohexose isomerase , structural glucose phosphate isomerase 1 , nemo like kinase b , nemo-like kinase , nemo-like kinase 2 , Nemo-like kinase , nemo like kinase , Nemo-Like kinase , serine/threonine-protein kinase NLK-like , glucose phosphate isomerase , serine/threonine protein kinase NLK , serine/threonine-protein kinase NLK , Serine/threonine-protein kinase NLK

GENE ID SPECIES
14751 Mus musculus
100058876 Equus caballus
405892 Danio rerio
414522 Xenopus laevis
445934 Takifugu rubripes
677693 Macaca mulatta
739132 Pan troglodytes
778685 Ciona intestinalis
100019356 Monodelphis domestica
100144638 Xenopus (Silurana) tropicalis
100348930 Oryctolagus cuniculus
100414864 Callithrix jacchus
100469296 Ailuropoda melanoleuca
100560802 Anolis carolinensis
100593981 Nomascus leucogenys
292804 Rattus norvegicus
18099 Mus musculus
497961 Rattus norvegicus
51701 Homo sapiens
507204 Bos taurus
491160 Canis lupus familiaris
417669 Gallus gallus
100511657 Sus scrofa
Selected quality suppliers for anti-Nemo-Like Kinase (NLK) Antibodies
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