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The protein encoded by NOV is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. Additionally we are shipping Nephroblastoma Overexpressed Proteins (19) and Nephroblastoma Overexpressed Kits (13) and many more products for this protein.
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Cow (Bovine) Polyclonal NOV Primary Antibody for WB - ABIN2781492
Fukunaga-Kalabis, Martinez, Telson, Liu, Balint, Juhasz, Elder, Perbal, Herlyn: Downregulation of CCN3 expression as a potential mechanism for melanoma progression. in Oncogene 2008
Studies indicate that the CYR61 (show CYR61 Antibodies) CTGF (show CTGF Antibodies) NOV matricellular proteins (CCN family of proteins) comprises the members CCN1 (show CCNA2 Antibodies), CCN2 (show CTGF Antibodies), CCN3, CCN4 (show WISP1 Antibodies), CCN5 (show WISP2 Antibodies) and CCN6 (show WISP3 Antibodies) and have been identified in various types of cancer.
NOV expression was highly increased in biopsies of patients with tubulointerstitial nephritis.
Results revealed that NOV regulates the tumor growth of osteosarcoma cells through activation of the MAPK (show MAPK1 Antibodies) signaling pathway and promotes osteosarcoma cell migration in vitro.
our results argue that MZF-1 (show ZFP42 Antibodies) regulates the CTGF (show CTGF Antibodies) and NOV genes in the hematopoietic compartment, and may be involved in their respective functions in the stroma.
Overexpression of CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment.
NOV may promote carcinogenesis via promotion of EMT (show ITK Antibodies) and association with increased mTOR (show FRAP1 Antibodies) activity
CCN3 can promote dentinogenesis by coordinating proliferation and odontoblastic differentiation of dental pulp stem cells via modulating Notch (show NOTCH1 Antibodies) and BMP2 (show BMP2 Antibodies) signaling pathways.
over-expression of NOV in pancreatic cancer cells promoted cell proliferation and migration, while knock down the expression of NOV impaired the tumorigenecity of pancreatic cancer cells in vitro and in vivo
CCN3 may play an important role in cervical carcinogenesis and therefore may have potential as a biomarker for prognosis and as a therapeutic target in cervical cancer.
Our findings establish a tumor-suppressive role of NOV in prostate cancer
Study showed that progenitor cells lining the telencephalic ventricles express PlexinA1 (show PLXNA1 Antibodies) and that absence of this receptor impairs neurogenesis in the developing forebrain
Genetic and pharmacological approaches implicated the ERK1/2 (show MAPK1/3 Antibodies) pathway as a critical regulator of CCN3-dependent AAA (show AAAS Antibodies) development.
Reduced NOV expression limits inflammation and interstitial renal fibrosis after obstructive nephropathy in mice.
NOV is required for the maintenance of articular cartilage and for joint homeostasis, with disruption of NOV in ageing Nov(del3)-/- male mice causing osteoarthritis-like disease.
tight regulation of CCN3 expression is necessary for normal cortical neuronal connectivity during development, and RAB25 (show RAB25 Antibodies) negatively regulates neuronal differentiation as a downstream effector of CCN3
CCN3 overexpression is associated with control of inflammatory processes and reversion of dyslipidemia in the process of atherosclerosis, which implies that CCN3 may be a promising target in the treatment of atherosclerosis.
PlexinA1 (show PLXNA1 Antibodies) mediates both Semaphorin and Slit signaling
genetic findings demonstrate that Sema3a (show SEMA3A Antibodies) repellent signaling plays a role in the establishment of proper afferent projections in SAG (show RNF7 Antibodies) neurons, and this signaling likely occurs through a receptor complex involving Npn1 (show NRP1 Antibodies) and either plexinA1 (show PLXNA1 Antibodies) or plexinA3 (show PLXNA3 Antibodies)
A novel direct interaction between the Sema3a (show SEMA3A Antibodies) signaling receptor plexinA1 (show PLXNA1 Antibodies) and nephrin (show NPHS1 Antibodies), linking extracellular Sema3a (show SEMA3A Antibodies) signals to the slit-diaphragm signaling complex, was identified.
in obese humans and mice plasma NOV levels positively correlated with NOV expression in adipose tissue, and support a possible contribution of NOV to obesity-related inflammation.
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development.
CCN family member 3
, IGF-binding protein 9
, insulin-like growth factor-binding protein 9
, nephroblastoma-overexpressed gene protein homolog
, protein NOV homolog
, nephroblastoma overexpressed gene protein homolog
, nephroblastoma overexpressed gene protein
, nephroblastoma-overexpressed gene protein
, protein NOV
, plex 1
, plexin 1