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anti-Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) Antibodies

NPHS1 encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. Additionally we are shipping Nephrin Kits (47) and Nephrin Proteins (16) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NPHS1 4868 O60500
NPHS1 64563 Q9R044
NPHS1 54631 Q9QZS7
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Top anti-Nephrin Antibodies at antibodies-online.com

Showing 10 out of 193 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Immunofluorescence in mouse kidney cells using Nephrin Antibody at 10 µg/ml. Immunohistochemistry in mouse kidney tissue using Nephrin Antibody at 1 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Guinea Pig Un-conjugated IF, IHC (p), WB   0.1 mL Log in to see 6 to 8 Days
$489.50
Details
Human Rabbit Un-conjugated EIA, IHC (p) Immunohistochemistry of Nephrin in human kidney tissue with Nephrin Antibody  at 5 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC (p) 7 mL Log in to see 2 to 3 Days
$237.00
Details
Human Mouse Un-conjugated IF, WB Nephrin Antibody (C-term)  western blot analysis in SK-BR-3 cell line lysates (15ug/lane).This demonstrates the Nephrin antibody detected the Nephrin protein (arrow).(1:100) Confocal immunofluorescent analysis of Nephrin Antibody (C-term)  with Hela cell followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue). 0.1 mL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated DB Dot blot analysis of anti-Phospho-Nephrin (Y1193) antibody Phospho-specific Pab (ABIN650883) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6 µg/mL. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated DB Dot blot analysis of anti-Phospho-Nephrin (Y1210) antibody Phospho-specific Pab (ABIN650884) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6 µg/mL. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (fro), IHC (p), WB Anti-Nephrin Picoband antibody,  IHC(F): Mouse Kidney Tissue Anti-Nephrin Picoband antibody,  IHC(P): Rat Kidney Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details

NPHS1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Nephrin Antibodies

  1. Human Polyclonal Nephrin Primary Antibody for IF, IHC (p) - ABIN113479 : Huber, Hartleben, Winkelmann, Schneider, Becker, Leitges, Walz, Haller, Schiffer: Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome. in Journal of the American Society of Nephrology : JASN 2009 (PubMed)
    Show all 13 references for ABIN113479

  2. Human Polyclonal Nephrin Primary Antibody for EIA, IF - ABIN500330 : Kestilä, Lenkkeri, Männikkö, Lamerdin, McCready, Putaala, Ruotsalainen, Morita, Nissinen, Herva, Kashtan, Peltonen, Holmberg, Olsen, Tryggvason: Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome. in Molecular cell 1998 (PubMed)
    Show all 3 references for ABIN500330

More Antibodies against Nephrin Interaction Partners

Zebrafish Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) interaction partners

  1. Nephrin signal bordered the lateral membrane of podocytes, which were columnar in shape

  2. Using two models, zebrafish and mice, that the absence of nephrin results in poorly developed muscles and incompletely fused myotubes, respectively.

Human Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) interaction partners

  1. there is a link found of the glomerular protein nephrin and the antihypertensive action of angiotensin receptor antagonists in the treatment of hypertension.

  2. A novel nonsense mutation in NPHS1 linking aortic stenosis associated with congenital nephropathy, is reported.

  3. Activated IQGAP1, as an intracellular partner of nephrin, is involved in actin cytoskeleton organization and functional regulation of podocytes.

  4. NPHS1 rs437168 variant is associated with nephrotic syndrome in children.

  5. biochemical reconstitution on supported lipid bilayers of protein clusters containing the adhesion receptor Nephrin and its cytoplasmic partners, Nck (show NCK1 Antibodies) and N-WASP (show WASL Antibodies), is reported.

  6. Coding variants in NPHS1 are associated with both risk for and protection from common forms of nephropathy in African Americans.

  7. Phosphorylation of nephrin is important for the survival status of podocytes.

  8. No pathogenic NPHS1 mutations were found in the cohort of children with steroid-resistant focal segmental glomerulosclerosis.

  9. Proteinuria in patients with seropositive rheumatoid arthritis is associated with increased levels of urine nephrin excretion, the highest levels of nephrin excretion were registered in patients with glomerulonephritis and amyloidosis.

  10. the frequency of identified disease causing mutations (NPHS1 and NPHS2) in children with steroid-resistant nephrotic syndome is 11.4%, and they show no response to treatment.

Mouse (Murine) Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) interaction partners

  1. interaction of full-length suPAR with alphavbeta3 integrin expressed on podocytes results in down-modulation of nephrin that may affect kidney functionality in different human pathologies characterized by increased concentration of suPAR.

  2. Nphs1 is an activity dependent gene in mouse olfactory sensory neurons.

  3. ACE2 (show ACE2 Antibodies) deficiency exacerbates kidney inflammation, oxidative stress and adverse renal injury in the ApoE (show APOE Antibodies)-mutant mice through modulation of the nephrin, NOX4 (show NOX4 Antibodies) and TNF-alpha (show TNF Antibodies)-TNFRSF1A (show TNFRSF1A Antibodies) signaling.

  4. Nephrin is involved in pancreatic beta-cell survival signaling; a marked decrease in nephrin expression and phosphorylated Akt (show AKT1 Antibodies) was observed in pancreatic islets of leptin receptor (show LEPR Antibodies)-deficient diabetic mice.

  5. SHP-1 (show PTPN6 Antibodies) contributes to nephrin deactivation in podocytes exposed to high glucose levels.

  6. The aPKC-Par3 (show F2RL2 Antibodies) complex regulates the cell-surface localization of nephrin.

  7. A novel direct interaction between the Sema3a (show SEMA3A Antibodies) signaling receptor plexinA1 (show PLXNA1 Antibodies) and nephrin, linking extracellular Sema3a (show SEMA3A Antibodies) signals to the slit-diaphragm signaling complex, was identified.

  8. The planar cell polarity pathway contributes to podocyte development by regulating nephrin turnover during junctional remodeling as the cells differentiate.

  9. Robo2 (show ROBO2 Antibodies) signaling acts as a negative regulator on nephrin to influence podocyte foot process architecture.

  10. Notch (show NOTCH1 Antibodies) signaling induces endocytosis of nephrin, thereby triggering the onset of proteinuria.

Nephrin (NPHS1) Antigen Profile

Protein Summary

This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.

Gene names and symbols associated with NPHS1

  • nephrosis 1, congenital, Finnish type (nephrin) (NPHS1) antibody
  • nephrosis 1, congenital, Finnish type (nephrin) (nphs1) antibody
  • nephrin (nphs1) antibody
  • nephrin (AaeL_AAEL003853) antibody
  • nephrosis 1, congenital, Finnish type (nephrin) (Nphs1) antibody
  • nephrosis 1, nephrin (Nphs1) antibody
  • CNF antibody
  • nephrin antibody
  • NephrinB antibody
  • NPHN antibody
  • nphs1 antibody
  • nphs1l antibody

Protein level used designations for NPHS1

nephrosis 1, congenital, Finnish type (nephrin) , nephrin , renal glomerulus-specific cell adhesion receptor , nephrosis 1 homolog, nephrin , nephrin 1

GENE ID SPECIES
468841 Pan troglodytes
692352 Danio rerio
734213 Xenopus laevis
5579127 Aedes aegypti
4868 Homo sapiens
64563 Rattus norvegicus
100354996 Oryctolagus cuniculus
100713185 Cavia porcellus
100622946 Sus scrofa
484571 Canis lupus familiaris
519706 Bos taurus
101115895 Ovis aries
54631 Mus musculus
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