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NPHS1 encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. Additionally we are shipping Nephrin Antibodies (188) and Nephrin Proteins (16) and many more products for this protein.
Showing 10 out of 37 products:
Rat (Rattus) Nephrin ELISA Kit for Sandwich ELISA - ABIN431840
Alter, Kretschmer, Von Websky, Tsuprykov, Reichetzeder, Simon, Stasch, Hocher: Early urinary and plasma biomarkers for experimental diabetic nephropathy. in Clinical laboratory 2012
Human Nephrin ELISA Kit for Sandwich ELISA - ABIN1116131
Petrica, Vlad, Gluhovschi, Gadalean, Dumitrascu, Gluhovschi, Velciov, Bob, Vlad, Popescu, Milas, Ursoniu: Proximal tubule dysfunction is associated with podocyte damage biomarkers nephrin and vascular endothelial growth factor in type 2 diabetes mellitus patients: a cross-sectional study. in PLoS ONE 2014
Nephrin signal bordered the lateral membrane of podocytes, which were columnar in shape
Using two models, zebrafish and mice, that the absence of nephrin results in poorly developed muscles and incompletely fused myotubes, respectively.
The classical form is CNF, which is caused by mutations in the nephrin gene (NPHS1), leading to massive proteinuria, hypoproteinemia and edema in the newborn period
there is a link found of the glomerular protein nephrin and the antihypertensive action of angiotensin receptor antagonists in the treatment of hypertension.
A novel nonsense mutation in NPHS1 linking aortic stenosis associated with congenital nephropathy, is reported.
Activated IQGAP1, as an intracellular partner of nephrin, is involved in actin cytoskeleton organization and functional regulation of podocytes.
NPHS1 rs437168 variant is associated with nephrotic syndrome in children.
biochemical reconstitution on supported lipid bilayers of protein clusters containing the adhesion receptor Nephrin and its cytoplasmic partners, Nck and N-WASP (show WASL ELISA Kits), is reported.
Coding variants in NPHS1 are associated with both risk for and protection from common forms of nephropathy in African Americans.
Phosphorylation of nephrin is important for the survival status of podocytes.
No pathogenic NPHS1 mutations were found in the cohort of children with steroid-resistant focal segmental glomerulosclerosis.
Proteinuria in patients with seropositive rheumatoid arthritis is associated with increased levels of urine nephrin excretion, the highest levels of nephrin excretion were registered in patients with glomerulonephritis and amyloidosis.
interaction of full-length suPAR with alphavbeta3 integrin expressed on podocytes results in down-modulation of nephrin that may affect kidney functionality in different human pathologies characterized by increased concentration of suPAR.
Nphs1 is an activity dependent gene in mouse olfactory sensory neurons.
ACE2 (show ACE2 ELISA Kits) deficiency exacerbates kidney inflammation, oxidative stress and adverse renal injury in the ApoE (show APOE ELISA Kits)-mutant mice through modulation of the nephrin, NOX4 (show NOX4 ELISA Kits) and TNF-alpha (show TNF ELISA Kits)-TNFRSF1A (show TNFRSF1A ELISA Kits) signaling.
Nephrin is involved in pancreatic beta-cell survival signaling; a marked decrease in nephrin expression and phosphorylated Akt (show AKT1 ELISA Kits) was observed in pancreatic islets of leptin receptor (show LEPR ELISA Kits)-deficient diabetic mice.
SHP-1 (show PTPN6 ELISA Kits) contributes to nephrin deactivation in podocytes exposed to high glucose levels.
The aPKC-Par3 (show F2RL2 ELISA Kits) complex regulates the cell-surface localization of nephrin.
A novel direct interaction between the Sema3a (show SEMA3A ELISA Kits) signaling receptor plexinA1 and nephrin, linking extracellular Sema3a (show SEMA3A ELISA Kits) signals to the slit-diaphragm signaling complex, was identified.
The planar cell polarity pathway contributes to podocyte development by regulating nephrin turnover during junctional remodeling as the cells differentiate.
Robo2 (show ROBO2 ELISA Kits) signaling acts as a negative regulator on nephrin to influence podocyte foot process architecture.
Notch (show NOTCH1 ELISA Kits) signaling induces endocytosis of nephrin, thereby triggering the onset of proteinuria.
This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.
nephrosis 1, congenital, Finnish type (nephrin)
, renal glomerulus-specific cell adhesion receptor
, nephrosis 1 homolog, nephrin
, nephrin 1