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May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.. Additionally we are shipping NHLH2 Kits (14) and NHLH2 Proteins (5) and many more products for this protein.
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Human Polyclonal NHLH2 Primary Antibody for EIA, WB - ABIN952711
Raychaudhuri, Thomson, Remmers, Eyre, Hinks, Guiducci, Catanese, Xie, Stahl, Chen, Alfredsson, Amos, Ardlie, , Barton, Bowes, Burtt, Chang, Coblyn, Costenbader, Criswell, Crusius, Cui, De Jager, Ding, Emery, Flynn, Harrison, Hocking, Huizinga, Kastner, Ke: Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. in Nature genetics 2009
Show all 5 references for ABIN952711
These data support part of our hypothesis that NHLH2 or MAO-A (show MAOA Antibodies) polymorphism is associated with sedentary behavior.
Leptin (show LEP Antibodies) signaling regulates hypothalamic expression of Nhlh2 through Stat3 (show STAT3 Antibodies).
Two single nucleotide polymorphisms in the human nescient helix-loop-helix 2 (NHLH2) gene reduce mRNA stability or reduce helical structure in the DNA binding domain of the protein.
The present results suggest that a transcriptional complex of LMO3 (show LMO3 Antibodies) and HEN2 may contribute to the genesis and malignant phenotype of neuroblastoma (show ARHGEF16 Antibodies) by inhibiting HES1 which suppresses the transactivation of Mash1 (show ASCL1 Antibodies).
The deregulated expression of neuronal-specific LMO3 (show LMO3 Antibodies) and HEN2 contributes to the genesis and progression of human neuroblastoma (show ARHGEF16 Antibodies) in a lineage-specific manner.
proposes the novel hypothesis that transcriptional activity by Nhlh2 (NHLH2 in humans) controls either the ability or the motivation for exercise [review]
suggested that the expression levels of Lmo3 and/or Hen2 could determine the fate of stem cells by inhibiting Hes1 function during nervous system development and might be a trigger of aberrant neurogenesis in vivo
We found that loss of Nscl-2 results in aberrant migration of gonadotropin releasing hormone neurons in Nscl-2 mutant mice causing a lineage switch of ectopically located gonadotropin releasing hormone neurons
Melanocortin 4 receptor (show MC4R Antibodies) is a transcriptional target of nescient helix-loop-helix-2
Nhlh2 in the central control of adipocyte function
Nhlh2 transcription factor has a role in controlling genes important to energy expenditure, and more specifically voluntary physical activity of animals
Regulation of body weight is linked to action of neuronal Nhlh2 on prohormone convertase mRNA levels. Direct role for transcriptional control of neuropeptide processing enzymes in etiology of adult-onset obesity.
N2KO mice (with targeted deletion of Nhlh2)have fewer pregnancies, abnormal estrus cycles, and release fewer oocytes as they age. N2KO females show at least a 50% reduction in hormone-stimulated sexual behavior as measured by their lordosis quotient.
Data show that NSCL-1 (show NHLH1 Antibodies) and -2, together with additional cofactors, directly control transcription of the necdin (show NDN Antibodies) gene.
We conclude that NSCL-1 (show NHLH1 Antibodies)/2 maintain migration and survival of cells in the migratory stream to the cerebellum.
Nhlh2 plays a role in the development and functional maintenance of the hypothalamic-pituitary-gonadal axis
The bovine Nhlh2 gene (bNHLH2) is cloned and shown to be highly conserved among bovine breeds.
May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
helix-loop-helix protein 2
, nescient helix loop helix 2
, class A basic helix-loop-helix protein 34