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NTN4 belongs to a family of proteins related to laminins (see LAMA1, MIM 150320) Koch et al. Additionally we are shipping Netrin 4 Antibodies (46) and Netrin 4 Kits (16) and many more products for this protein.
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the crucial role of Netrin-4 in blood vessel formation and the involvement of protein kinases activation in Netrin-4-induced biological effects related to vascular development.
netrin 4 is detected only at very low levels during early development
We found statistically significant association with AAO for three genes (WRN, NTN4 and LAMC3 (show LAMC3 Proteins)) with common associated variants.
Ntn4 promotes the proliferation and motility of gastric cancer cells which is mediated by its receptor Neo and through further activation of multi-oncogenic pathways
Increased expression of miR (show MLXIP Proteins)-20a may play an important role in the pathogenesis of ovarian endometriosis by suppressing NTN4 expression.
Increased maternal netrin-4 levels in IUGR neonates may reflect in utero hypoxia, while the negative correlations between fetal netrin-1 (show NTN1 Proteins) and -4 levels may exert the dynamic balance between their angio- and anti-angiogenic properties.
NTN4 acts as a positive regulator for TC axon branching through activity-dependent expression
NETRIN-4 protects glioblastoma cells FROM temozolomide induced senescence.
NTN4 expression was downregulated in cervical cancer tissues compared to normal controls, and in vivo mRNA level of NTN4 inversely correlated with miR (show MLXIP Proteins)-196a expression.
GWAS study found two new SNPs associated with nickel dermatitis; SNPs are located in the NTN4 and PELI1 (show PELI1 Proteins) genes
pattern of distribution suggests that a functional netrin-4-neogenin (show NEO1 Proteins) pathway might be restricted to syncytiotrophoblasts, mesenchymal cells, and villous endothelial cells
glioma cells reduce netrin-4 expression to decrease its inhibitory effects.
Our results indicate a role for netrin-4 as an angiogenesis modulating factor in O2-dependent vascular homeostasis while being less important during normal retinal developmental angiogenesis or during inflammatory neovascularization.
These results indicate that netrin-4 shed new light on its potential roles in treatmenting for angiogenic diseases that affect the ocular surface, as well as other tissues
Vascular endothelial cells interact with bone in suppressing bone through netrin-4.
Loss of Netrin-4 is associated with metastatic colorectal tumor progression.
The alpha6beta1 integrin is a netrin-4 receptor in endothelial cells.
NT-4 (show NTF4 Proteins) overexpression decreases tumor growth and carcinomatosis, probably via an antiangiogenic effect
In vivo, Netrin-4 induces growth of lymphatic and blood vessels in the skin of transgenic mice.
netrin-4 is a component of basement membranes and is integrated into the laminin polymer via interactions with the laminin gamma1 andgamma3 short arms.
Netrin-4 significantly reduced pathological angiogenesis in Matrigel and laser-induced choroidal neovascularization models. Netrin-4, neogenin (show NEO1 Proteins), and Unc5B (show UNC5B Proteins) receptor expression was up-regulated in choroidal neovessel EC after laser injury
Netrin-4 may improve poststroke functional recovery by enhancing blood vessel proliferation
NTN4 belongs to a family of proteins related to laminins (see LAMA1, MIM 150320) Koch et al. (2000)
, hepar-derived netrin-like protein