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NEDD4 Proteins

(Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4))

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19193720). Predominantly involved in ubiquitination of membrane bound forms of ERBB4 rather than processed precursors and intermediate membrane-anchored 80 kDa fragments (m80HER4), with a lesser role in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19047365). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity).

recommended

NEDD4 Protein (AA 791-900) (GST tag) (ABIN1312320)

NEDD4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

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recommended

NEDD4 Protein (AA 1-1319) (Strep Tag) (ABIN3094038)

Crystallography grade NEDD4 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS

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recommended

NEDD4 Protein (AA 1-887) (Strep Tag) (ABIN3134115)

Crystallography grade NEDD4 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS

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NEDD4 Proteins by Grade

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NEDD4 Proteins by Origin

Find NEDD4 Proteins for a variety of species such as anti-Human NEDD4, anti-Mouse NEDD4, anti-Rat NEDD4. The species listed below are among those available. Click on a link to go to the corresponding products.

NEDD4 Proteins by Source

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NEDD4 Proteins by Protein Type

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NEDD4 Proteins by Application

Find NEDD4 Proteins validated for a specific application such as WB, ELISA, SDS, AP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular NEDD4 Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

NEDD4 Protein (AA 791-900) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1312320

Quantity 10 μg

Datasheet Datasheet

NEDD4 Protein (AA 1-1319) (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3094038

Quantity 1 mg

Datasheet Datasheet

NEDD4 Protein (AA 1-887) (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3134115

Quantity 1 mg

Datasheet Datasheet

NEDD4 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2727061

Quantity 20 μg

Datasheet Datasheet

NEDD4 Protein

Reactivity Mouse, Rat

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN2750635

Quantity 5 applications

Datasheet Datasheet

Aliases for NEDD4 Proteins

neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (NEDD4) Proteins
neural precursor cell expressed, developmentally down-regulated 4 (Nedd4) Proteins
CG42279 gene product from transcript CG42279-RJ (Nedd4) Proteins
E3 ubiquitin-protein ligase Nedd-4 (LOC411723) Proteins
E3 ubiquitin-protein ligase NEDD4 (LOC100457150) Proteins
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (nedd4) Proteins
E3 ubiquitin-protein ligase NEDD4 (LOC100547485) Proteins
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (Nedd4) Proteins
AA959633 Proteins
AL023035 Proteins
AU019897 Proteins
CG7555 Proteins
CG32184 Proteins
CG42279 Proteins
Dmel\\CG42279 Proteins
Dmel_CG7555 Proteins
Dmel_CG32184 Proteins
DNedd4 Proteins
dNedd4 Proteins
dNedd4-1 Proteins
E430025J12Rik Proteins
GB16853 Proteins
mKIAA0093 Proteins
nedd4 Proteins
NEDD4 Proteins
Nedd4 Proteins
NEDD4-1 Proteins
Nedd4-1 Proteins
Nedd4a Proteins
RPF1 Proteins

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NEDD4 Proteins by Grade

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Popular NEDD4 Proteins

Aliases for NEDD4 Proteins

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