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Neural Retina Leucine Zipper Proteins (NRL)

NRL encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. Additionally we are shipping NRL Antibodies (15) and NRL Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NRL 4901 P54845
Rat NRL NRL 290221  
NRL 18185 P54846
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Top NRL Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details

NRL Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Neural Retina Leucine Zipper (NRL) Interaction Partners

Cow (Bovine) Neural Retina Leucine Zipper (NRL) interaction partners

  1. the function of NRL is modulated by its interaction with specific repressor proteins, related to cross-talk between signaling pathways in the retina.

Zebrafish Neural Retina Leucine Zipper (NRL) interaction partners

  1. REEP6.1 is a key functional target of NRL (show NRF1 Proteins)-centered transcriptional regulatory network in rod photoreceptors.

Human Neural Retina Leucine Zipper (NRL) interaction partners

  1. In another family a variant, p.M96T in the NRL gene was detected as a retinitis pigmentosa-causing mutation.

  2. This novel p.M96T mutant activated the RHO promoter more intensely than did wild-type NRL in a family with autosomal dominant retinitis pigmentosa.

  3. Studies suggest an important role of sumoylation in fine-tuning the activity of NRL and thereby incorporating yet another layer of control in gene regulatory networks involved in photoreceptor development and homeostasis.

  4. In this study, NR2E3 (show NR2E3 Proteins) mutations were found to be responsible for approximately 2.9% of overall retinitis pigmentosa (RP) in Chinese patients, NRL was not associated with RP.

  5. The disease caused by NRL mutations found in this study appears to be more severe

  6. Mutation screening of patients with Leber Congenital Amaurosis or the enhanced S-Cone Syndrome reveals a lack of sequence variations in the NRL gene.

  7. the function of NRL is modulated by its interaction with specific repressor proteins, related to cross-talk between signaling pathways in the retina

  8. The NRL Ser50Thr mutation is associated with selective loss of scotopic function before age 20 years. With time, however, the photopic system becomes affected, leading to loss of the photopic visual field and of visual acuity.

  9. both Nrl and Crx (show CRX Proteins) are required for full transcriptional activity of the PDE6A (show PDE6A Proteins) gene

  10. the function of NRL-MTD (show MT1E Proteins) is to activate transcription by recruiting or stabilizing TBP (show TBP Proteins) (and consequently other components of the general transcription complex) at the promoter of target genes

Mouse (Murine) Neural Retina Leucine Zipper (NRL) interaction partners

  1. CNGA3 (show CNGA3 Proteins) expression restored cone function in in CNGA3 (show CNGA3 Proteins)-/-/Nrl-/- mice, an all-cone model of CNGA3 (show CNGA3 Proteins) achromatopsia.

  2. REEP6.1 is a key functional target of NRL-centered transcriptional regulatory network in rod photoreceptors.

  3. Data indicate that positive feedback between neural retina leucine zipper factor (NRL) and retinoid-related orphan receptor beta (show RORB Proteins) gene (Rorb (show RORB Proteins)) genes reinforces the commitment to a rod differentiation fate.

  4. shRNA-mediated knockdown of Crx (show CRX Proteins) and Nrl resulted in reduced Kcnv2 (show KCNV2 Proteins) promoter activity and low endogenous Kcnv2 (show KCNV2 Proteins) mRNA expression in the retina.

  5. This study analyzed the retinal pigment epithelium from Nrl(-/-) mice of various ages for lipofuscin fluorescence and A2E levels.

  6. Findings suggest that elimination of Nrl in adult rods may represent a unique therapy for retinal degeneration.

  7. Our results show that NRL and CRX (show CRX Proteins) together control the expression of most, if not all, genes involved in rod phototransduction through a cis (show CISH Proteins)-regulatory module

  8. found that Nrl activated rhodopsin and Ppp2r5c (show PPP2CA Proteins) transcription by recruiting Tip60 (show KAT5 Proteins) to promote histone H3 (show HIST3H3 Proteins)/H4 acetylation

  9. Nrl as a direct transcriptional target of RORbeta (show RORB Proteins) and suggest that combinatorial action of multiple regulatory factors modulates the expression of Nrl in developing and mature retina.

  10. Nrl-deficient retina may serve as a model for elucidating mechanisms of cone homeostasis and degeneration that would be relevant to understanding diseases of the cone-dominant human macula.

NRL Protein Profile

Protein Summary

This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases.

Gene names and symbols associated with NRL

  • neural retina leucine zipper (nrl)
  • neural retina leucine zipper (NRL)
  • neural retina leucine zipper (Nrl)
  • neural retina leucine zipper (LOC100342474)
  • neural retina leucine zipper gene (Nrl)
  • D14H14S46E protein
  • D14S46E protein
  • l-maf protein
  • l-maf-A protein
  • Nrl protein
  • NRL-MAF protein
  • RP27 protein
  • XL-maf protein
  • zgc:136315 protein

Protein level used designations for NRL

neural retina leucine zipper , bZIP transcription factor L-Maf , leucine zipper transcription factor , neural retina-specific leucine zipper protein , neural retinal-specific leucine zipper

GENE ID SPECIES
373814 Xenopus laevis
452806 Pan troglodytes
490620 Canis lupus familiaris
521544 Bos taurus
554169 Danio rerio
613052 Xenopus (Silurana) tropicalis
714967 Macaca mulatta
100127447 Sus scrofa
100192392 Cavia porcellus
100342474 Oryctolagus cuniculus
4901 Homo sapiens
290221 Rattus norvegicus
18185 Mus musculus
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