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Neuro-Oncological Ventral Antigen 1 Proteins (NOVA1)

NOVA1 encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. Additionally we are shipping NOVA1 Antibodies (69) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NOVA1 4857 P51513
NOVA1 664883 Q9JKN6
NOVA1 298992  
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Top NOVA1 Proteins at antibodies-online.com

Showing 6 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,336.67
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,366.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NOVA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Neuro-Oncological Ventral Antigen 1 (NOVA1) Interaction Partners

Human Neuro-Oncological Ventral Antigen 1 (NOVA1) interaction partners

  1. Quantitative proteomic analysis was performed to help elucidate a molecular distinction between glioblastoma and oligodendroglioma; analysis showed HSPB1 (show HSPB1 Proteins) and NOVA1 to be discriminating factors.

  2. Data indicate RNA binding protein (show PTBP1 Proteins) NOVA1 as a target of microRNA miR (show MLXIP Proteins)-339.

  3. MiR (show MLXIP Proteins)-181b-5p is a tumor suppressor in astrocytoma that inhibits tumor progression by targeting NOVA1.

  4. High expression of NOVA1 correlates with poor prognosis in hepatocellular carcinoma.

  5. a regulation of LEDGF (show PSIP1 Proteins) interaction with chromatin by cellular partners of its PWWP domain could be involved in several processes linked to LEDGF (show PSIP1 Proteins) tethering properties, such as lentiviral integration, DNA repair or transcriptional regulation

  6. Gene silencing and overexpression of the nELAV member HuD (show ELAVL4 Proteins) in motoneuronal NSC34 cells indicate that Nova1 mRNA stability and translation are positively and strongly controlled by the nELAV proteins

  7. Semiquantitative estimation of circulating anti-Ri antibodies demonstrated a renewed increase in antibody levels preceding relapse of the cancer, as confirmed using F-fluorodeoxyglucose positron emission tomography (FDG (show SMUG1 Proteins)-PET)

Mouse (Murine) Neuro-Oncological Ventral Antigen 1 (NOVA1) interaction partners

  1. identify Nova-1 and hnRNP M (show HNRNPM Proteins) as D2R (show DRD2 Proteins) pre-mRNA-binding proteins and show their antagonistic role in the alternative splicing of D2R (show DRD2 Proteins) pre-mRNA.

  2. integrative network revealed combinatorial regulation by Nova (show HNRNPK Proteins) and the neuronal splicing factor (show SLU7 Proteins) Fox, interplay between phosphorylation and splicing, and potential links to neurologic disease

  3. Nova (show HNRNPK Proteins) regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer

  4. CLIP (cross-linking and immunoprecipitation) reveals Nova (show HNRNPK Proteins) coordinately regulates a biologically coherent set of RNAs encoding multiple components of the inhibitory synapse, an observation that may relate to the cause of abnormal motor inhibition in POMA

  5. These studies demonstrate that in addition to its previously described role as a splicing activator, Nova-1 autoregulates its own expression by acting as a splicing repressor.

  6. Assays of splicing intermediates of Nova (show HNRNPK Proteins)-regulated transcripts in mouse brain revealed that Nova (show HNRNPK Proteins) preferentially regulates removal of introns harbouring (or closest to) YCAY clusters

  7. Gene silencing and overexpression of the nELAV member HuD (show ELAVL4 Proteins) in motoneuronal NSC34 cells indicate that Nova1 mRNA stability and translation are positively and strongly controlled by the nELAV proteins

  8. Nova1/Nova2 (show NOVA2 Proteins) double knockout mice are paralyzed and fail to cluster AChRs at the neuromuscular junction, and breeding them with transgenic mice constitutively expressing Z(+) agrin (show AGRN Proteins) in motor neurons rescued AChR clustering

NOVA1 Protein Profile

Protein Summary

This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.

Gene names and symbols associated with NOVA1

  • neuro-oncological ventral antigen 1 (NOVA1)
  • neuro-oncological ventral antigen 1 (nova1)
  • neuro-oncological ventral antigen 1 (LOC100348769)
  • lipid A export ATP-binding/permease protein (novA1)
  • neuro-oncological ventral antigen 1 (Nova1)
  • RNA-binding protein Nova-1-like (NOVA1)
  • 9430099M15Rik protein
  • G630039L02 protein
  • Nova-1 protein
  • NOVA1 protein
  • si:ch211-222c22.9 protein

Protein level used designations for NOVA1

neuro-oncological ventral antigen 1 , lipid A export ATP-binding/permease protein , RNA-binding protein Nova-1 , onconeural ventral antigen 1 , paraneoplastic Ri antigen , ventral neuron-specific protein 1

GENE ID SPECIES
452828 Pan troglodytes
533792 Bos taurus
100124925 Xenopus (Silurana) tropicalis
100348769 Oryctolagus cuniculus
7801470 Corynebacterium aurimucosum ATCC 700975
555590 Danio rerio
444572 Xenopus laevis
4857 Homo sapiens
490632 Canis lupus familiaris
664883 Mus musculus
298992 Rattus norvegicus
423300 Gallus gallus
790874 Bos taurus
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