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NBEA encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Additionally we are shipping Neurobeachin Kits (3) and and many more products for this protein.
Showing 10 out of 38 products:
Rat (Rattus) Polyclonal Neurobeachin Primary Antibody for ICC, IHC - ABIN1742399
Lauks, Klemmer, Farzana, Karupothula, Zalm, Cooke, Li, Smit, Toonen, Verhage: Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin. in PLoS ONE 2012
Show all 4 Pubmed References
Rat (Rattus) Polyclonal Neurobeachin Primary Antibody for ICC, WB - ABIN1742400
Murray, Low, Swanson, Dieriks, Turner, Faull, Curtis: Distribution of PSA-NCAM in normal, Alzheimer's and Parkinson's disease human brain. in Neuroscience 2016
Human Polyclonal Neurobeachin Primary Antibody for ELISA, IHC - ABIN188661
Wang, Herberg, Laue, Wullner, Hu, Petrasch-Parwez, Kilimann: Neurobeachin: A protein kinase A-anchoring, beige/Chediak-higashi protein homolog implicated in neuronal membrane traffic. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2001
This study demonistrated that functional homologies between Drosophila Rugose and mammalian NBEA that will help clarify the role of BEACH proteins in the development and function of the CNS in vivo.
Drosophila spoonbill encodes a dual-specificity A-kinase anchor protein (show CELSR3 Antibodies) essential for oogenesis.
results suggest that rg is required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR (show EGFR Antibodies) and Notch (show NOTCH1 Antibodies) signaling pathways
results suggest that rugose gene encodes a secondary pigment cell specific function, and plays an essential role in determining the optic lobe's structure
Rugose (rg) plays an important role in the integration of different signals required for the exact regulation of cone cell development and survival.
NBEA encodes neurobeachin: we found no evidence of association in data from the GWAS migraine meta-analysis consortium (n=118,710 participants) suggesting that the association might be specific to migraine co-morbid with bipolar disorder.
Data indicate that the PVT1-NBEA and the PVT1-WWOX (show WWOX Antibodies) chimeric genes were associated with the expression of abnormal NBEA and WWOX (show WWOX Antibodies).
Synapse associated protein 102 (SAP102 (show DLG3 Antibodies)) binds the C-terminal part of the scaffolding protein neurobeachin.
data obtained in mice and humans suggest that variation of Nbea abundance or activity critically affects body weight, presumably by influencing the activity of feeding-related neural circuits
neurobeachin encoding gene is disrupted in a patient with a de novo translocation t(5;13) (q12.1;q13.2), idiopathic autism, and no family history of autism
The NBEA gene at 13q13, and its expression are frequently disrupted in MM.
Nbea targets glutamate (show GRIN1 Antibodies) and GABA receptors to the synapse via distinct molecular pathways by interacting with specific effector proteins.
The physical interaction of NBEA with NOTCH1 (show NOTCH1 Antibodies) is most relevant for autism spectrum disorders pathogenesis because NOTCH (show NOTCH1 Antibodies) signaling is essential for neural development.
These findings indicate that Nbea haploinsufficiency leads to various molecular and cellular changes that affect neuroplasticity and behavioral functions in mice
Nbea regulates synaptic transmission under basal conditions by targeting neurotransmitter receptors to synapses.
Data show that deletion of Nbea leads to reduced numbers of spinous synapses in cultured neurons from complete knockouts and in cortical tissue from heterozygous mice, accompanied by altered miniature postsynaptic currents.
Nbea-null mice suffered block of evoked synaptic transmission at neuromuscular junctions, whereas nerve conduction, synaptic structure and synaptic vesicle release were normal supporting a neurotransmitter release role of Nbea at neuromuscular junctions
Our data demonstrate for the first time a function of Nbea at central synapses that may be based on its presumed role in targeting membrane proteins to synaptic contacts.
This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.
A kinase anchor protein 550
, drosophila A kinase anchor protein
, lysosomal-trafficking regulator 2
, lysosomal trafficking regulator 2