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Neurocan Proteins (NCAN)

Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002].. Additionally we are shipping Neurocan Antibodies (40) and Neurocan Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat NCAN NCAN 58982  
NCAN 1463 O14594
NCAN 13004 P55066
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Top Neurocan Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

NCAN Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Neurocan (NCAN) Interaction Partners

Human Neurocan (NCAN) interaction partners

  1. NCAN genotype is associated with limbic gray matter alterations in healthy and subjects with major depression in brain areas implicated in emotion perception and regulation

  2. current data demonstrate that common genetic variation in NCAN influences both neural processing and cognitive performance in healthy subjects.

  3. The frequency of the NCAN rs2228603 T allele was significantly increased in patients with HCC (show FAM126A Proteins) due to ALD (15.1%) compared to alcoholic cirrhosis without HCC (show FAM126A Proteins) (9.3%), alcoholic controls (7.2%), healthy controls (7.9%), and HCV associated HCC (show FAM126A Proteins) (9.1%).

  4. NCAN risk variant is associated with cortical folding and thickness in bipolar disorder and schizophrenia.

  5. Conditional analysis shows that a neighbouring gene, TM6SF2, not NCAN, is responsible for the Chr 19 GWAS locus previously associated with fibrosing non-alcoholic fatty liver disease (NAFLD).

  6. NCAN rs2228603[T] is a risk factor for liver inflammation and fibrosis, suggesting that this locus is responsible for progression from steatosis to steatohepatitis.

  7. no genetic association between risk allele A for NCAN locus rs1064395 and schizophrenia.

  8. In the combined patient sample, the NCAN risk allele was significantly associated with the "mania" factor, in particular the subdimension "overactivity.

  9. The rs1064395 A-allele was significantly over-represented in schizophrenia patients compared to controls. Our data suggest that genetic variation in NCAN is a common risk factor for bipolar disorder and schizophrenia.

  10. High neurocan is associated with the invasive phenotype of low-grade astrocytoma.

Mouse (Murine) Neurocan (NCAN) interaction partners

  1. This study provided evidence that the neurocan modulates synaptogenesis and long-term synapse stability. The mutant neurons display reduced frequencies of mEPSCs and mIPSCs.

  2. Traumatic brain injury results in an increase in the chondroitin glycosaminoglycans (CSPGs) neurocan and NG2 (show Vcan Proteins) expression in a tight band surrounding the injury core.

  3. Ncan -/- mice showed behavioral abnormalities that were strikingly similar to those of the human mania phenotype.

  4. neurocan contributes to the molecular heterogeneity of the perinodal matrix, and its nodal expression is dependent on Bral1 (show HAPLN2 Proteins).

  5. this shows a heterophilic molecular interaction between cell adhesion molecular L1 and neurocan is involved in determining the thalamocortical pathway within the neocortical anlage

  6. PTPsigma (show PTPRS Proteins) binds with high affinity to neural chondroitin sulfate proteoglycans(CPSGs); binding involves chondroitin sulfate chains & a specific site on 1st immunoglobulin-like domain of PTPsigma (show PTPRS Proteins); results indicate PTPsigma (show PTPRS Proteins) can act as a receptor for CSPGs

Neurocan (NCAN) Protein Profile

Protein Summary

Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.

Gene names and symbols associated with Neurocan Proteins (NCAN)

  • neurocan b (ncanb)
  • neurocan (NCAN)
  • neurocan (Ncan)
  • C230035B04 protein
  • Cspg3 protein
  • Cspg3-rs protein
  • NCAN protein
  • si:ch211-123b7.1 protein
  • Tgfbit protein

Protein level used designations for Neurocan Proteins (NCAN)

chondroitin sulfate proteoglycan 3 (neurocan) , 245 kDa early postnatal core glycoprotein , chondroitin sulfate proteoglycan 3 , neurocan core protein , neurocan proteoglycan , TGFbeta-induced transcript, brain , chondroitin sulfate proteoglycan 3, related sequence

559024 Danio rerio
720340 Macaca mulatta
58982 Rattus norvegicus
1463 Homo sapiens
13004 Mus musculus
100717528 Cavia porcellus
523701 Bos taurus
484808 Canis lupus familiaris
395493 Gallus gallus
101105820 Ovis aries
468775 Pan troglodytes
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